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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Graham, B.S."

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Search Summary

This query matches 38 Structures.

Refinements

Structure Determination Methodology

experimental (38)

Scientific Name of Source Organism

Homo sapiens (38)

Taxonomy

Eukaryota (38)

Experimental Method

X-RAY DIFFRACTION (38)

Polymer Entity Type

Protein (38)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (11)
	2.5 - 3.0 (9)
	3.0 - 3.5 (13)
	3.5 - 4.0 (2)

Release Date

	2015 - 2019 (9)
	2020 - 2024 (29)

Enzyme Classification Name

Transferases (36)

Symmetry Type

	Asymmetric (26)
	Cyclic (13)

SCOP Classification

	Alpha and beta proteins (a+b) (1)
	All alpha proteins (2)

AllSelected

1 to 25 of 38 Structures

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5W5V \| pdb_00005w5v	Download File View File

TBK1 co-crystal structure with amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Mol Pharmacol 94: 1210-1219

Released	2018-06-27
Method	X-RAY DIFFRACTION 3.645 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	ANW

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6BNY \| pdb_00006bny	Download File View File

TBK1 in complex with tetrazole analog of amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Mol Pharmacol 94: 1210-1219

Released	2018-09-26
Method	X-RAY DIFFRACTION 3.341 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	E0M

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6BOD \| pdb_00006bod	Download File View File

TBK1 in complex with ethyl ester analog of amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Mol Pharmacol 94: 1210-1219

Released	2018-09-26
Method	X-RAY DIFFRACTION 3.197 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	E0P

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6BOE \| pdb_00006boe	Download File View File

TBK1 in complex with amide-coupled tetrazole analog of amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Mol Pharmacol 94: 1210-1219

Released	2018-09-26
Method	X-RAY DIFFRACTION 3.598 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	E0S

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6CQ0 \| pdb_00006cq0	Download File View File

TBK1 in Complex with Dimethyl Amino Analog of Amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Bioorg Med Chem 26: 5443-5461

Released	2018-12-05
Method	X-RAY DIFFRACTION 3.19 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	F8M

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6CQ4 \| pdb_00006cq4	Download File View File

TBK1 in Complex with Cyclohexyl Analog of Amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Bioorg Med Chem 26: 5443-5461

Released	2018-12-05
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	F8P

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6CQ5 \| pdb_00006cq5	Download File View File

TBK1 in Complex with Sulfone Analog of Amlexanox

Beyett, T.S., Tesmer, J.J.G.

(2018) Bioorg Med Chem 26: 5443-5461

Released	2018-12-05
Method	X-RAY DIFFRACTION 3.354 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase TBK1 (protein)
Unique Ligands	F8S

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6EEB \| pdb_00006eeb	Download File View File

Calmodulin in complex with malbrancheamide

Beyett, T.S., Fraley, A.E., Tesmer, J.J.G.

(2019) Proc Natl Acad Sci U S A 116: 15895-15900

Released	2019-08-07
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Homo sapiens
Macromolecule	Calmodulin-1 (protein)
Unique Ligands	CA, J6P, ZN

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6O5G \| pdb_00006o5g	Download File View File

Calmodulin in complex with isomalbrancheamide D

Beyett, T.S., Fraley, A.E., Tesmer, J.J.G.

(2019) Proc Natl Acad Sci U S A 116: 15895-15900

Released	2019-08-07
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Calmodulin-1 (protein)
Unique Ligands	CA, LMJ, ZN

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7JXH \| pdb_00007jxh	Download File View File

HER2 in complex with JBJ-08-178-01

Beyett, T.S., Eck, M.J.

(2022) Cancer Res 82: 1633-1645

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.27 Å
Organisms	Homo sapiens
Macromolecule	Receptor tyrosine-protein kinase erbB-2 (protein)
Unique Ligands	VOY

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

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7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXQ \| pdb_00007jxq	Download File View File

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Cancer 3: 402-417

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7JXW \| pdb_00007jxw	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1H \| pdb_00007k1h	Download File View File

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 2.602 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1I \| pdb_00007k1i	Download File View File

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 3.202 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7KXZ \| pdb_00007kxz	Download File View File

Active conformation of EGFR kinase in complex with BI-4020

Beyett, T.S., Eck, M.J.

(2024) ChemMedChem e202300343-e202300343

Released	2022-01-19
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CL, XA4

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7KY0 \| pdb_00007ky0	Download File View File

Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020

Beyett, T.S., Eck, M.J.

(2024) ChemMedChem e202300343-e202300343

Released	2022-01-19
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	XA4

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7LG8 \| pdb_00007lg8	Download File View File

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.93 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8RC, VNS

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7LTX \| pdb_00007ltx	Download File View File

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Bioorg Med Chem Lett 68: 128718-128718

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, YFA