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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "UNQ277/PRO314/PRO34092"

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

	Homo sapiens (22)
	Methanosarcina mazei (1)

Taxonomy

	Eukaryota (22)
	Archaea (1)

Experimental Method

	X-RAY DIFFRACTION (17)
	ELECTRON MICROSCOPY (3)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.0 - 2.5 (3)
	2.5 - 3.0 (10)
	3.0 - 3.5 (4)
	3.5 - 4.0 (1)
	4.0 - 4.5 (1)

Release Date

	2015 - 2019 (19)
	2020 - 2024 (3)

Enzyme Classification Name

Transferases (22)

Symmetry Type

	Cyclic (13)
	Asymmetric (7)
	Helical (2)

SCOP Classification

	Alpha and beta proteins (a+b) (13)
	All alpha proteins (1)

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1 to 22 of 22 Structures

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2N7Z \| pdb_00002n7z	Download File View File

Solution structure of RIP2 CARD

Lin, Z., Ibanez, C.F.

(2015) Elife 4: 11692-11692

Released	2015-12-23
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)

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2N83 \| pdb_00002n83	Download File View File

p75NTR DD:RIP2 CARD

Lin, Z., Ibanez, C.F.

(2015) Elife 4: 11692-11692

Released	2015-12-23
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein) Tumor necrosis factor receptor superfamily member 16 (protein)

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5J79 \| pdb_00005j79	Download File View File

The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, Compound 3 complex

Convery, M.A., Casillas, L.N., Haile, P.A., Votta, B.J., Lakdawala, A.S.

(2016) J Med Chem 59: 4867-4880

Released	2016-05-18
Method	X-RAY DIFFRACTION 2.69 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	6GE, SO4

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5J7B \| pdb_00005j7b	Download File View File

The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, GSK583 complex

Convery, M.A., Casillas, L.N., Haile, P.A., Votta, B.J., Lakdawala, A.S.

(2016) J Med Chem 59: 4867-4880

Released	2016-05-18
Method	X-RAY DIFFRACTION 2.53 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	6GD

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5NG0 \| pdb_00005ng0	Download File View File

Structure of RIP2K(L294F) with bound AMPPCP

Pellegrini, E., Cusack, S.

(2017) PLoS One 12: e0177161-e0177161

Released	2017-06-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	ACP, CO, MG

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5NG2 \| pdb_00005ng2	Download File View File

Structure of RIP2K(D146N) with bound Staurosporine

Pellegrini, E., Cusack, S.

(2017) PLoS One 12: e0177161-e0177161

Released	2017-06-07
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	PO4, STU

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5NG3 \| pdb_00005ng3	Download File View File

Structure of inactive kinase RIP2K(K47R)

Pellegrini, E., Cusack, S.

(2017) PLoS One 12: e0177161-e0177161

Released	2017-06-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	SO4

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5W5J \| pdb_00005w5j	Download File View File

Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases

Kreusch, A., Spraggon, G.

(2017) ACS Med Chem Lett 8: 1048-1053

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	9WS, SO4

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5W5O \| pdb_00005w5o	Download File View File

Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.

Kreusch, A., Spraggon, G.

(2017) ACS Med Chem Lett 8: 1048-1053

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.89 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	9XA

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5YRN \| pdb_00005yrn	Download File View File

Structure of RIP2 CARD domain

Wu, B., Gong, Q.

(2018) Nat Commun 9: 4993-4993

Released	2018-11-14
Method	ELECTRON MICROSCOPY 4.1 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)

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6ES0 \| pdb_00006es0	Download File View File

Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35

Pinkas, D.M., Bufton, J.C., Suebsuwong, C., Ray, S.S., Dai, B., Newman, J.A., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Degterev, A., Cuny, G.D., Bullock, A.N.

(2018) Bioorg Med Chem Lett 28: 577-583

Released	2018-02-21
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	BW8

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6FU5 \| pdb_00006fu5	Download File View File

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18

Pinkas, D.M., Bufton, J.C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.

(2018) EMBO J 37:

Released	2018-04-25
Method	X-RAY DIFFRACTION 3.26 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	E7N

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6GFJ \| pdb_00006gfj	Download File View File

Structure of RIP2 CARD domain fused to crystallisable MBP tag

Pellegrini, E., Cusack, S.

(2018) Nat Commun 9: 4043-4043

Released	2019-03-13
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Homo sapiens Methanosarcina mazei
Macromolecule	Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique branched monosaccharides	GLC

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6GGS \| pdb_00006ggs	Download File View File

Structure of RIP2 CARD filament

Pellegrini, E., Cusack, S., Desfosses, A., Schoehn, G., Malet, H., Gutsche, I., Sachse, C., Hons, M.

(2018) Nat Commun 9: 4043-4043

Released	2018-10-17
Method	ELECTRON MICROSCOPY 3.94 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)

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6HMX \| pdb_00006hmx	Download File View File

RIP2 Kinase Catalytic Domain complex with N(4,5dimethyl1Hpyrazol3yl)7methoxy6(2methylpropane2sulfonyl)quinolin4amine

Convery, M.A., Haile, P.A.

(2018) ACS Med Chem Lett 9: 1039-1044

Released	2018-11-07
Method	X-RAY DIFFRACTION 2.53 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	GEZ

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6RN8 \| pdb_00006rn8	Download File View File

RIP2 Kinase Catalytic Domain complex with 2(4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl)oxy)ethyl phosphate

Convery, M.A., Haile, P.A.

(2019) J Med Chem 62: 6482-6494

Released	2019-07-17
Method	X-RAY DIFFRACTION 2.69 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	CA, K9T

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6RNA \| pdb_00006rna	Download File View File

RIP2 Kinase Catalytic Domain complex with 2({4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl}oxy)ethan1ol

Convery, M.A., Haile, P.A.

(2019) J Med Chem 62: 6482-6494

Released	2019-07-17
Method	X-RAY DIFFRACTION 2.62 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	KA2

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6S1F \| pdb_00006s1f	Download File View File

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

Pinkas, D.M., Bufton, J.C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.

To be published

Released	2019-10-16
Method	X-RAY DIFFRACTION 3.11 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	KRE

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6UL8 \| pdb_00006ul8	Download File View File

RIP2 kinase catalytic domain complex with (5S,6S,8R)-2-(benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide

Shewchuk, L.M., Convery, M.A.

(2019) ACS Med Chem Lett 10: 1518-1523

Released	2019-12-04
Method	X-RAY DIFFRACTION 2.68 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	CA, Q9J

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8AZA \| pdb_00008aza	Download File View File

Structure of RIP2K dimer bound to the XIAP BIR2 domain

Pellegrini, E., Cusack, S.

(2023) Life Sci Alliance 6:

Released	2022-10-26
Method	ELECTRON MICROSCOPY 3.15 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase XIAP (protein) Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	ZN

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8X2O \| pdb_00008x2o	Download File View File

RIPK2 in complex with K252

Yang, J.H., Yang, J.H.

To be published

Released	2024-11-13
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	6IL

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9F3V \| pdb_00009f3v	Download File View File

RIP2K kinase domain dimer with bound compound 37 (N399), a speific NOD1 pathway inhibitor

Cusack, S., Huard, K., Pellegrini, E.

(2024) J Med Chem 67: 19304-19322

Released	2024-11-06
Method	X-RAY DIFFRACTION 1.943 Å
Organisms	Homo sapiens
Macromolecule	Receptor-interacting serine/threonine-protein kinase 2 (protein)
Unique Ligands	A1H90

1 to 22 of 22 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2N7Z | pdb_00002n7z

2N83 | pdb_00002n83

5J79 | pdb_00005j79

5J7B | pdb_00005j7b

5NG0 | pdb_00005ng0

5NG2 | pdb_00005ng2

5NG3 | pdb_00005ng3

5W5J | pdb_00005w5j

5W5O | pdb_00005w5o

5YRN | pdb_00005yrn

6ES0 | pdb_00006es0

6FU5 | pdb_00006fu5

6GFJ | pdb_00006gfj

6GGS | pdb_00006ggs

6HMX | pdb_00006hmx

6RN8 | pdb_00006rn8

6RNA | pdb_00006rna

6S1F | pdb_00006s1f

6UL8 | pdb_00006ul8

8AZA | pdb_00008aza

8X2O | pdb_00008x2o

9F3V | pdb_00009f3v