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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "TTL"

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Search Summary

This query matches 253 Structures.

Refinements

Structure Determination Methodology

experimental (253)

Scientific Name of Source Organism

	Gallus gallus (248)
	Rattus norvegicus (221)
	Bos taurus (177)
	Sus scrofa (75)
	Mus musculus (19)
	Homo sapiens (10)
	Sus barbatus (7)
	Xenopus tropicalis (3)
	synthetic construct (2)
	Arabidopsis thaliana (1)

More...

Taxonomy

	Eukaryota (253)
	other sequences (2)

Experimental Method

X-RAY DIFFRACTION (253)

Polymer Entity Type

Protein (253)

Refinement Resolution (Å)

	1.5 - 2.0 (10)
	2.0 - 2.5 (130)
	2.5 - 3.0 (105)
	3.0 - 3.5 (7)
	3.5 - 4.0 (1)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (13)
	2015 - 2019 (85)
	2020 - 2024 (151)
	2025 - 2029 (3)

Enzyme Classification Name

	Hydrolases (242)
	Ligases (20)
	Lyases (1)

Symmetry Type

	Asymmetric (252)
	Cyclic (1)

SCOP Classification

	Alpha and beta proteins (a/b) (179)
	Alpha and beta proteins (a+b) (179)
	All alpha proteins (177)
	Artifacts (166)

AllSelected

1 to 25 of 253 Structures

Page 1 of 11

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2Q37 \| pdb_00002q37	Download File View File

Crystal structure of OHCU decarboxylase in the presence of (S)-allantoin

Kim, K.

(2007) J Biological Chem 282: 23457-23464

Released	2007-06-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Arabidopsis thaliana
Macromolecule	OHCU decarboxylase (protein)
Unique Ligands	3AL

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3TIG \| pdb_00003tig	Download File View File

Tubulin tyrosine ligase

Roll-Mecak, A., Szyk, A., Deaconescu, A., Piszczek, G.

(2011) Nat Struct Mol Biol 18: 1250-1258

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Xenopus tropicalis
Macromolecule	Ttl protein (protein)
Unique Ligands	MG

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3TII \| pdb_00003tii	Download File View File

Tubulin tyrosine ligase

Roll-Mecak, A., Szyk, A., Deaconescu, A., Piszczek, G.

(2011) Nat Struct Mol Biol 18: 1250-1258

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Xenopus tropicalis
Macromolecule	Ttl protein (protein)
Unique Ligands	ANP, MG

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3TIN \| pdb_00003tin	Download File View File

Tubulin tyrosine ligase

Roll-Mecak, A., Szyk, A., Deaconescu, A., Piszczek, G.

(2011) Nat Struct Mol Biol 18: 1250-1258

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Xenopus tropicalis
Macromolecule	Ttl protein (protein)
Unique Ligands	ADP, MG

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4I4T \| pdb_00004i4t	Download File View File

Crystal structure of tubulin-RB3-TTL-Zampanolide complex

Prota, A.E., Steinmetz, M.O.

(2013) Science 339: 587-590

Released	2013-01-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin Tyrosine ligase, TTL (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ACP, CA, CL, GDP, GOL, GTP, MES, MG, TYR, ZPN

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4I50 \| pdb_00004i50	Download File View File

Crystal structure of tubulin-stathmin-TTL-Epothilone A complex

Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.

(2013) Science 339: 587-590

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin Tyrosine Ligase, TTL (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ACP, CA, CL, EP, GDP, GOL, GTP, MES, MG

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4I55 \| pdb_00004i55	Download File View File

Crystal structure of tubulin-stathmin-TTL complex

Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.

(2013) Science 339: 587-590

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin tyrosine ligase, TTL (protein)
Unique Ligands	ACP, CA, CL, GDP, GTP, MES, MG

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4IHJ \| pdb_00004ihj	Download File View File

Crystal structure of tubulin-stathmin-TTL-ADP complex

Prota, A.E., Magiera, M.M., Kuijpers, M., Bargsten, K., Frey, D., Wieser, M., Jaussi, R., Hoogenraad, C.C., Kammerer, R.A., Janke, C., Steinmetz, M.O.

(2013) J Cell Biol 200: 259-270

Released	2013-02-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) TUBULIN TYROSINE LIGASE, TTL (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ADP, CA, CL, GDP, GOL, GTP, MES, MG

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4IIJ \| pdb_00004iij	Download File View File

Crystal structure of tubulin-stathmin-TTL-apo complex

Prota, A.E., Magiera, M.M., Kuijpers, M., Bargsten, K., Frey, D., Wieser, M., Jaussi, R., Hoogenraad, C.C., Kammerer, R.A., Janke, C., Steinmetz, M.O.

(2013) J Cell Biol 200: 259-270

Released	2013-01-30
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin tyrosine ligase, TTL (protein)
Unique Ligands	CA, CL, GDP, GTP, MES, MG

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4O2A \| pdb_00004o2a	Download File View File

Tubulin-BAL27862 complex

Prota, A.E., Franck, D., Bachmann, F., Bargsten, K., Buey, R.M., Pohlmann, J., Reinelt, S., Lane, H., Steinmetz, M.O.

(2014) J Mol Biology 426: 1848-1860

Released	2014-03-05
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) TUBULIN-TYROSINE LIGASE (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	2RR, ADP, CA, CL, GDP, GOL, GTP, IMD, MES, MG

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4O2B \| pdb_00004o2b	Download File View File

Tubulin-Colchicine complex

Prota, A.E., Franck, D., Bachmann, F., Bargsten, K., Buey, R.M., Pohlmann, J., Reinelt, S., Lane, H., Steinmetz, M.O.

(2014) J Mol Biology 426: 1848-1860

Released	2014-03-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-tyrosine ligase (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, IMD, LOC, MES, MG, PEG

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4TUY \| pdb_00004tuy	Download File View File

Tubulin-Rhizoxin complex

Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.

(2014) Proc Natl Acad Sci U S A 111: 13817-13821

Released	2014-08-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	36L, ACP, CA, GDP, GTP, MES, MG

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4TV8 \| pdb_00004tv8	Download File View File

Tubulin-Maytansine complex

Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.

(2014) Proc Natl Acad Sci U S A 111: 13817-13821

Released	2014-08-27
Method	X-RAY DIFFRACTION 2.103 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	3GT, ACP, CA, GDP, GOL, GTP, MES, MG

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4TV9 \| pdb_00004tv9	Download File View File

Tubulin-PM060184 complex

Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.

(2014) Proc Natl Acad Sci U S A 111: 13817-13821

Released	2014-08-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Uncharacterized protein (protein)
Unique Ligands	3H4, ACP, CA, GDP, GOL, GTP, MES, MG

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4YJ2 \| pdb_00004yj2	Download File View File

Crystal structure of tubulin bound to MI-181

McNamara, D.E., Torres, J.Z., Yeates, T.O.

(2015) Protein Sci 24: 1164-1172

Released	2015-05-27
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-tyrosine ligase (protein)
Unique Ligands	4ED, CA, GDP, GOL, GTP, IMD, MES, MG

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4YJ3 \| pdb_00004yj3	Download File View File

Crystal structure of tubulin bound to compound 2

McNamara, D.E., Torres, J.Z., Yeates, T.O.

(2015) Protein Sci 24: 1164-1172

Released	2015-05-27
Method	X-RAY DIFFRACTION 3.75 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-tyrosine ligase (protein)
Unique Ligands	4EE, CA, GDP, GTP, IMD, MES, MG

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4ZHQ \| pdb_00004zhq	Download File View File

Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex

Wang, Y., Zhang, R.

(2016) Mol Pharmacol 89: 233-242

Released	2016-07-27
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	4Q5, ACP, CA, GDP, GOL, GTP, MES, MG

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4ZI7 \| pdb_00004zi7	Download File View File

CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX

Wang, Y., Zhang, R.

(2016) Mol Pharmacol 89: 233-242

Released	2016-07-27
Method	X-RAY DIFFRACTION 2.51 Å
Organisms	Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	4SL, ACP, CA, GDP, GOL, GTP, MES, MG

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4ZOL \| pdb_00004zol	Download File View File

Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex

Wang, Y., Zhang, R.

(2016) Mol Pharmacol 89: 233-242

Released	2016-07-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein) Tubulin-tyrosine ligase (protein)
Unique Ligands	55Q, ACP, CA, GDP, GOL, GTP, MES, MG

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5BMV \| pdb_00005bmv	Download File View File

CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX

Wang, Y., Chen, Q., Zhang, R.

(2016) Mol Pharmacol 89: 233-242

Released	2016-07-13
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, MES, MG, VLB

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5C8Y \| pdb_00005c8y	Download File View File

Crystal structure of T2R-TTL-Plinabulin complex

Wang, Y., Yu, Y., Chen, Q., Yang, J.

(2016) FEBS J 283: 102-111

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.594 Å
Organisms	Gallus gallus Rattus norvegicus Sus barbatus
Macromolecule	Stathmin-4 (protein) Tubulin alpha (protein) Tubulin beta (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GTP, MES, MG, PN6

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5CA0 \| pdb_00005ca0	Download File View File

Crystal structure of T2R-TTL-Lexibulin complex

Wang, Y., Yu, Y., Chen, Q., Yang, J.

(2016) FEBS J 283: 102-111

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.501 Å
Organisms	Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, LXL, MES, MG

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5CA1 \| pdb_00005ca1	Download File View File

Crystal structure of T2R-TTL-Nocodazole complex

Wang, Y., Yu, Y., Chen, Q., Yang, J.

(2016) FEBS J 283: 102-111

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.401 Å
Organisms	Gallus gallus Rattus norvegicus Sus barbatus
Macromolecule	Stathmin-4 (protein) Tubulin alpha (protein) Tubulin beta-2 chain (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, MES, MG, NZO

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5CB4 \| pdb_00005cb4	Download File View File

Crystal structure of T2R-TTL-Tivantinib complex

Wang, Y., Yu, Y., Chen, Q., Yang, J.

(2016) FEBS J 283: 102-111

Released	2015-11-04
Method	X-RAY DIFFRACTION 2.193 Å
Organisms	Gallus gallus Rattus norvegicus Sus barbatus
Macromolecule	Stathmin-4 (protein) Tubulin alpha (protein) Tubulin beta (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, MES, MG, TIV

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5EZY \| pdb_00005ezy	Download File View File

Crystal structure of T2R-TTL-taccalonolide AJ complex

Wang, Y., Yu, Y., Chen, Q., Yang, J.

(2017) Nat Commun 8: 15787-15787

Released	2017-01-11
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus Sus scrofa
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Uncharacterized protein (protein)
Unique Ligands	ACP, CA, GDP, GTP, MES, MG, TAJ

1 to 25 of 253 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2Q37 | pdb_00002q37

3TIG | pdb_00003tig

3TII | pdb_00003tii

3TIN | pdb_00003tin

4I4T | pdb_00004i4t

4I50 | pdb_00004i50

4I55 | pdb_00004i55

4IHJ | pdb_00004ihj

4IIJ | pdb_00004iij

4O2A | pdb_00004o2a

4O2B | pdb_00004o2b

4TUY | pdb_00004tuy

4TV8 | pdb_00004tv8

4TV9 | pdb_00004tv9

4YJ2 | pdb_00004yj2

4YJ3 | pdb_00004yj3

4ZHQ | pdb_00004zhq

4ZI7 | pdb_00004zi7

4ZOL | pdb_00004zol

5BMV | pdb_00005bmv

5C8Y | pdb_00005c8y

5CA0 | pdb_00005ca0

5CA1 | pdb_00005ca1

5CB4 | pdb_00005cb4

5EZY | pdb_00005ezy