GTP

GUANOSINE-5'-TRIPHOSPHATE

Created: 1999-07-08
Last modified:  2013-03-22

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Chemical Details

Formal Charge0
Atom Count48
Chiral Atom Count4
Bond Count50
Aromatic Bond Count5
2D diagram of GTP
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Chemical Component Summary

NameGUANOSINE-5'-TRIPHOSPHATE
Systematic Name (OpenEye OEToolkits)[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
SMILESCACTVS3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
SMILESOpenEye OEToolkits1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Canonical SMILESCACTVS3.370 NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
Canonical SMILESOpenEye OEToolkits1.7.6 c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
InChIInChI1.03 InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyInChI1.03 XKMLYUALXHKNFT-UUOKFMHZSA-N

Drug Info: DrugBank

DrugBank IDDB04137 
NameGuanosine-5'-Triphosphate
Groups experimental
DescriptionGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]
SynonymsGuanosine-5'-Triphosphate
CAS number86-01-1

Drug Targets

NameTarget SequencePharmacological ActionActions
RNA-directed RNA polymeraseMPRRAPAFPLSDIKAQMLFANNIKAQQASKRSFKEGAIETYEGLLSVDPR...unknown
Uridine-cytidine kinase-like 1MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPP...unknown
GTPase HRasMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET...unknown
Genome polyproteinMSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRAPR...unknown
Rho-related GTP-binding protein RhoEMKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPE...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1233147
PubChem 135398633, 6830, 5280317
ChEMBL CHEMBL1233147
ChEBI CHEBI:15996