TYR

TYROSINE

Created:	1999-07-08
Last modified:	2024-09-27

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77 entries where TYR is found as a standalone ligand24 entries where TYR is covalently linked to polymer or other heterogen groups 219,050 entries where TYR is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	6

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Chemical Component Summary
Name	TYROSINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Formula	C₉ H₁₁ N O₃
Molecular Weight	181.189
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)Cc1ccc(O)cc1
SMILES	CACTVS	3.341	N[CH](Cc1ccc(O)cc1)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1CC(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](Cc1ccc(O)cc1)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C[C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKey	InChI	1.03	OUYCCCASQSFEME-QMMMGPOBSA-N

Drug Info: DrugBank

DrugBank ID	DB00135
Name	Tyrosine
Groups	approved investigational nutraceutical
Description	Tyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin.
Synonyms	4-hydroxy-L-phenylalanine (S)-Tyrosine (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid (S)-3-(p-Hydroxyphenyl)alanine (S)-α-amino-4-hydroxybenzenepropanoic acid (S)-(-)-Tyrosine Tyrosinum Tyr L-tyrosine (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid Tirosina Tyrosine Y (−)-α-amino-p-hydroxyhydrocinnamic acid L-Tyrosin (S)-alpha-amino-4-Hydroxybenzenepropanoic acid
Brand Names	2.75% Travas. Amino Acid InJ.W.elecw.25%dex 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 3.3% E Vamin N Aminosyn 8.5% Injection With Electrolytes Clinimix Aminosyn Nutrineal Pd4 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Primene 10% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Oil Travasol Amino Acid Inj 8.5% Smofkabiven Electrolyte Free 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Olimel 7.6% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn 7% 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Plenamine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Appbutamone Aminosyn 3.5% M 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Primene 10%-liq IV Clinimix E Clinisol 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Olimel 5.7% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Olimel 7.6% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Travasol E 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Vamin 18 Electrolyte-free Aminosyn-PF Olimel 5.7% E Premasol - sulfite-free (Amino Acid) 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn 10% W Electrolytes Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Aminosyn-PF 10% Primene Appformin-D Appbutamone-D Novamine Aminosyn 5% Aminosyn 8.5% Periolimel 2.5% E Travasol Inj Without Electrolytes 8.5% Travasol Inj Without Electrolytes 5.5% Travasol Amino Acid Inj 5.5% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Travasol Renamin (amino Acids) Injection Smofkabiven Synthamin Olimel 4.4% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose ProSol 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Appformin Aminosyn-PF 7% TrophAmine Smofkabiven Extra Nitrogen Electrolyte Free Smofkabiven Extra Nitrogen 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix 20% Prosol Essepna Olimel 4.4% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Peripheral Kabiven
Indication	Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
Categories	Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	60-18-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosine 3-monooxygenase	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA...	unknown	binder
Tyrosine--tRNA ligase, mitochondrial	MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKD...	unknown
Tyrosine--tRNA ligase, cytoplasmic	MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHV...	unknown
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Monocarboxylate transporter 8	MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE...	unknown	inhibitor
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682