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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Jang, J."

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

	Homo sapiens (20)
	Schizosaccharomyces pombe 972h- (3)
	Severe acute respiratory syndrome coronavirus 2 (3)
	Cryptosporangium aurantiacum (2)
	Escherichia coli K-12 (1)
	Mycobacterium tuberculosis H37Rv (1)
	Saccharomyces cerevisiae (1)
	Spodoptera frugiperda (1)

Taxonomy

	Eukaryota (24)
	Bacteria (4)
	Riboviria (3)

Experimental Method

	X-RAY DIFFRACTION (26)
	ELECTRON MICROSCOPY (4)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (31)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (4)
	2.0 - 2.5 (10)
	2.5 - 3.0 (7)
	3.0 - 3.5 (5)
	3.5 - 4.0 (1)
	4.0 - 4.5 (2)

Release Date

	2015 - 2019 (8)
	2020 - 2024 (23)

Enzyme Classification Name

	Transferases (20)
	Hydrolases (6)
	Oxidoreductases (1)
	Lyases (1)

Symmetry Type

	Cyclic (21)
	Asymmetric (9)
	Helical (1)

SCOP Classification

	Alpha and beta proteins (a+b) (7)
	All beta proteins (1)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 31 Structures

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5D41 \| pdb_00005d41	Download File View File

EGFR kinase domain in complex with mutant selective allosteric inhibitor

Yun, C.-H., Park, E., Eck, M.J.

(2016) Nature 534: 129-132

Released	2016-06-08
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	57N, ANP, MG

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6D8E \| pdb_00006d8e	Download File View File

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

Park, E., Eck, M.J.

(2018) Angew Chem Int Ed Engl 57: 11629-11633

Released	2018-07-18
Method	X-RAY DIFFRACTION 2.537 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	FZP

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6DUK \| pdb_00006duk	Download File View File

EGFR with an allosteric inhibitor

Park, E., Eck, M.J.

(2019) Cancer Discov 9: 926-943

Released	2019-06-05
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG

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6JPQ \| pdb_00006jpq	Download File View File

CryoEM structure of Abo1 hexamer - ADP complex

Cho, C., Jang, J., Song, J.J.

(2019) Nat Commun 10: 5764-5764

Released	2020-08-19
Method	ELECTRON MICROSCOPY 4.44 Å
Organisms	Schizosaccharomyces pombe 972h-
Macromolecule	Uncharacterized AAA domain-containing protein C31G5.19 (protein)

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6JPU \| pdb_00006jpu	Download File View File

CryoEM structure of Abo1 hexamer - apo complex

Cho, C., Jang, J., Song, J.J.

(2019) Nat Commun 10: 5764-5764

Released	2019-12-25
Method	ELECTRON MICROSCOPY 4.27 Å
Organisms	Schizosaccharomyces pombe 972h-
Macromolecule	Uncharacterized AAA domain-containing protein C31G5.19 (protein)

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6JQ0 \| pdb_00006jq0	Download File View File

CryoEM structure of Abo1 Walker B (E372Q) mutant hexamer - ATP complex

Cho, C., Jang, J., Song, J.J.

(2019) Nat Commun 10: 5764-5764

Released	2019-12-25
Method	ELECTRON MICROSCOPY 3.54 Å
Organisms	Schizosaccharomyces pombe 972h- Spodoptera frugiperda
Macromolecule	Uncharacterized AAA domain-containing protein C31G5.19 (protein) unknown substrate (protein)
Unique Ligands	ADP, ATP

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6P1D \| pdb_00006p1d	Download File View File

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1

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6P1L \| pdb_00006p1l	Download File View File

Crystal structure of EGFR in complex with EAI045

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG

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6P8Q \| pdb_00006p8q	Download File View File

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

Yun, C.H., Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AMP, ANP, EDO, MG, O57

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6WYI \| pdb_00006wyi	Download File View File

Crystal structure of EchA19, enoyl-CoA hydratase from Mycobacterium tuberculosis

Bonds, A.C., Garcia-Diaz, M., Sampson, N.S.

(2020) ACS Infect Dis 6: 2214-2224

Released	2020-07-29
Method	X-RAY DIFFRACTION 1.915 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	EchA19, enoyl-CoA hydratase (protein)
Unique Ligands	MG

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7BVP \| pdb_00007bvp	Download File View File

AdhE spirosome in extended conformation

Kim, G.J., Song, J.J.

(2020) Commun Biol 3: 298-298

Released	2020-06-24
Method	ELECTRON MICROSCOPY 3.45 Å
Organisms	Escherichia coli K-12
Macromolecule	Aldehyde-alcohol dehydrogenase (protein)
Unique Ligands	NAD, ZN

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7JXH \| pdb_00007jxh	Download File View File

HER2 in complex with JBJ-08-178-01

Beyett, T.S., Eck, M.J.

(2022) Cancer Res 82: 1633-1645

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.27 Å
Organisms	Homo sapiens
Macromolecule	Receptor tyrosine-protein kinase erbB-2 (protein)
Unique Ligands	VOY

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

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7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXQ \| pdb_00007jxq	Download File View File

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Cancer 3: 402-417

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7JXW \| pdb_00007jxw	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1H \| pdb_00007k1h	Download File View File

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 2.602 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1I \| pdb_00007k1i	Download File View File

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 3.202 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7KX5 \| pdb_00007kx5	Download File View File

Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A

Sacco, M., Wang, J., Chen, Y.

(2021) J Am Chem Soc 143: 20697-20709

Released	2020-12-16
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	GOL, X7V

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7LG8 \| pdb_00007lg8	Download File View File

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.93 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8RC, VNS

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7LTX \| pdb_00007ltx	Download File View File

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Bioorg Med Chem Lett 68: 128718-128718

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, YFA

1 to 25 of 31 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

5D41 | pdb_00005d41

6D8E | pdb_00006d8e

6DUK | pdb_00006duk

6JPQ | pdb_00006jpq

6JPU | pdb_00006jpu

6JQ0 | pdb_00006jq0

6P1D | pdb_00006p1d

6P1L | pdb_00006p1l

6P8Q | pdb_00006p8q

6WYI | pdb_00006wyi

6XL4 | pdb_00006xl4

7BVP | pdb_00007bvp

7JXH | pdb_00007jxh

7JXI | pdb_00007jxi

7JXK | pdb_00007jxk

7JXL | pdb_00007jxl

7JXM | pdb_00007jxm

7JXP | pdb_00007jxp

7JXQ | pdb_00007jxq

7JXW | pdb_00007jxw

7K1H | pdb_00007k1h

7K1I | pdb_00007k1i

7KX5 | pdb_00007kx5

7LG8 | pdb_00007lg8

7LTX | pdb_00007ltx