8JOG | pdb_00008jog

solution structure of Ras Binding Domein (RBD) in C-RAF with negative allosteric modulator.

PDB DOI: https://doi.org/10.2210/pdb8JOG/pdb

Classification: SIGNALING PROTEIN
Organism(s): Homo sapiens
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2023-06-07 Released: 2024-06-12
Deposition Author(s): Makino, Y., Matsumoto, S., Yoshikawa, Y., Kawamura, T., Kumasaka, T., Shima, F.
Funding Organization(s): Japan Agency for Medical Research and Development (AMED), Japan Science and Technology

Experimental Data Snapshot

Method: SOLUTION NMR
Conformers Calculated: 20
Conformers Submitted: 20
Selection Criteria: 20

wwPDB Validation 3D Report Full Report

This is version 1.0 of the entry. See complete history.

Literature

Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers

Yoshikawa, Y., Makino, Y., Kubota, H., Kawamura, T., Matsumoto, S., Yuki, H., Shibaike, A., Okamura, M., Okada, T., Kataoka, T., Honma, T., Kumasaka, T., Koyama, H., Shima, F.

To be published.

Macromolecule Content

Total Structure Weight: 9.62 kDa
Atom Count: 672
Modelled Residue Count: 86
Deposited Residue Count: 86
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
RAF proto-oncogene serine/threonine-protein kinase	A	86	Homo sapiens	Mutation(s): 0 Gene Names: RAF1, RAF EC: 2.7.11.1
UniProt & NIH Common Fund Data Resources
Find proteins for P04049 (Homo sapiens) Explore P04049 Go to UniProtKB: P04049
PHAROS: P04049 GTEx: ENSG00000132155
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P04049
Sequence Annotations Expand
Reference Sequence LOADING

Experimental Data & Validation

Experimental Data

Method: SOLUTION NMR
Conformers Calculated: 20
Conformers Submitted: 20
Selection Criteria: 20

Structure Validation

View Full Validation Report

Entry History & Funding Information

Deposition Data

Released Date: 2024-06-12

Deposition Author(s):

Funding Organization	Location	Grant Number
Japan Agency for Medical Research and Development (AMED)	Japan	17nk0101309h0003
Japan Science and Technology	Japan	22-20103170

Revision History (Full details and data files)

Version 1.0: 2024-06-12
Type: Initial release

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.