Download MendeleyBiohybrid Electrospun Membrane for the Filtration of Ketoprofen Drug from Water.
Castagna, R., Donini, S., Colnago, P., Serafini, A., Parisini, E., Bertarelli, C.(2019) ACS Omega 4: 13270-13278
- PubMed: 31460455
- DOI: https://doi.org/10.1021/acsomega.9b01442
- Primary Citation of Related Structures:
6QS9 - PubMed Abstract:
A current challenge in materials science and biotechnology is to express a specific and controlled functionality on the large interfacial area of a nanostructured material to create smart biohybrid systems for targeted applications. Here, we report on a biohybrid system featuring poly(vinyl alcohol) as the supporting synthetic polymer and bovine serum albumin as the biofunctional element. The optimal processing conditions to produce these self-standing composite membranes are determined, and the composition and distribution of the bioactive agent within the polymeric matrices are analyzed. A post-processing cross-linking using glutaraldehyde enables this functional membrane to be used as a chemical filter in aqueous environments. By demonstrating that our mats can remove large amounts of ketoprofen from water, we show that the combination of a BSA-induced biofunctionality with a nanostructured fibrous material allows for the development of an efficient biohybrid filtering device for the large and widely used family of nonsteroidal anti-inflammatory drugs (NSAIDs). The crystal structure of the complex between BSA and ketoprofen is determined for the first time and confirms the interaction between the two species.
Organizational Affiliation:
Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, piazza L. da Vinci 32, 20133 Milano, Italy.
