Download MendeleyStructural insight into the central element assembly of the synaptonemal complex
Lu, J., Gu, Y., Feng, J., Zhou, W., Yang, X., Shen, Y.(2014) Sci Rep 4: 7059-7059
- PubMed: 25394919
- DOI: https://doi.org/10.1038/srep07059
- Primary Citation of Related Structures:
4R3Q - PubMed Abstract:
The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements.
Organizational Affiliation:
1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China [2] College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
