Download MendeleyCrystal Structure of the Urokinase
Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.To be published.
4FUI
Crystal Structure of the Urokinase
- PDB DOI: https://doi.org/10.2210/pdb4FUI/pdb
- Classification: HYDROLASE/HYDROLASE INHIBITOR
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2012-06-28 Released: 2012-08-22
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.209
- R-Value Work: 0.164
- R-Value Observed: 0.166
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Urokinase-type plasminogen activator | 246 | Homo sapiens | Mutation(s): 2 Gene Names: PLAU EC: 3.4.21.73 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P00749 (Homo sapiens) Explore P00749 Go to UniProtKB: P00749 | |||||
PHAROS: P00749 GTEx: ENSG00000122861 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00749 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 5 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| UI3 Query on UI3 | B [auth A] | 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE C16 H16 N4 O3 S KQUXAFOLFXHVQN-UHFFFAOYSA-N |  | ||
| SIN Query on SIN | K [auth A] | SUCCINIC ACID C4 H6 O4 KDYFGRWQOYBRFD-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | C [auth A], D [auth A], E [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | F [auth A], G [auth A], H [auth A], I [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| NA Query on NA | J [auth A] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.209
- R-Value Work: 0.164
- R-Value Observed: 0.166
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 55.1 | α = 90 |
| b = 53.4 | β = 90 |
| c = 80.25 | γ = 90 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALEPACK | data scaling |
| BUSTER-TNT | refinement |
| PDB_EXTRACT | data extraction |
| BUSTER | refinement |
Entry History
Deposition Data
- Released Date: 2012-08-22 Deposition Author(s): Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.
Revision History (Full details and data files)
- Version 1.0: 2012-08-22
Type: Initial release - Version 1.1: 2017-11-15
Changes: Advisory, Refinement description - Version 1.2: 2024-11-20
Changes: Advisory, Data collection, Database references, Derived calculations, Structure summary
