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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "EGFR"

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Search Summary

This query matches 263 Structures.

Refinements

Structure Determination Methodology

experimental (263)

Scientific Name of Source Organism

	Homo sapiens (263)
	Lama glama (6)
	Escherichia coli H489 (2)
	Mus musculus (2)

Taxonomy

	Eukaryota (263)
	Bacteria (2)

Experimental Method

	X-RAY DIFFRACTION (250)
	ELECTRON MICROSCOPY (9)
	SOLUTION NMR (4)

Polymer Entity Type

Protein (263)

Refinement Resolution (Å)

	1.0 - 1.5 (6)
	1.5 - 2.0 (35)
	2.0 - 2.5 (71)
	2.5 - 3.0 (98)
	3.0 - 3.5 (41)
	3.5 - 4.0 (5)
	4.0 - 4.5 (1)
	> 4.5 (2)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (34)
	2015 - 2019 (90)
	2020 - 2024 (128)
	2025 - 2029 (10)

Enzyme Classification Name

Transferases (263)

Membrane Protein Annotation

	MemProtMD (4)
	PDBTM (4)
	OPM (3)
	mpstruc (1)

Symmetry Type

	Asymmetric (222)
	Cyclic (45)
	Helical (1)

SCOP Classification

	Alpha and beta proteins (a+b) (104)
	All beta proteins (8)
	Artifacts (16)
	Small proteins (7)
	Alpha and beta proteins (a/b) (5)

AllSelected

1 to 25 of 263 Structures

Page 1 of 11

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2M0B \| pdb_00002m0b	Download File View File

Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles

Lesovoy, D.M., Bocharov, E.V., Pustovalova, Y.E., Bocharova, O.V., Arseniev, A.S.

(2016) Biochim Biophys Acta 1858: 1254-1261

Released	2013-10-30
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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2M20 \| pdb_00002m20	Download File View File

EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.

Endres, N.F., Das, R., Smith, A., Arkhipov, A., Kovacs, E., Huang, Y., Pelton, J.G., Shan, Y., Shaw, D.E., Wemmer, D.E., Groves, J.T., Kuriyan, J.

(2013) Cell 152: 543-556

Released	2013-02-20
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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2N5S \| pdb_00002n5s	Download File View File

Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles

Mineev, K., Bocharov, E., Bocharova, O., Arseniev, A.

(2015) Biochemistry 54: 6295-6298

Released	2015-10-14
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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3GT8 \| pdb_00003gt8	Download File View File

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

Jura, N., Endres, N.F., Engel, K., Deindl, S., Das, R., Lamers, M.H., Wemmer, D.E., Zhang, X., Kuriyan, J.

(2009) Cell 137: 1293-1307

Released	2009-07-21
Method	X-RAY DIFFRACTION 2.955 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) Unknown peptide (protein)
Unique Ligands	ANP, MG

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3W2O \| pdb_00003w2o	Download File View File

EGFR Kinase domain T790M/L858R Mutant with TAK-285

Sogabe, S., Kawakita, Y., Igaki, S.

(2013) ACS Med Chem Lett 4: 201-205

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	03P

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3W2P \| pdb_00003w2p	Download File View File

EGFR Kinase domain T790M/L858R mutant with compound 2

Sogabe, S., Kawakita, Y., Igaki, S.

(2013) ACS Med Chem Lett 4: 201-205

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	W2P

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3W2Q \| pdb_00003w2q	Download File View File

EGFR kinase domain T790M/L858R mutant with HKI-272

Sogabe, S., Kawakita, Y., Igaki, S.

(2013) ACS Med Chem Lett 4: 201-205

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	HKI, MES

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3W2R \| pdb_00003w2r	Download File View File

EGFR Kinase domain T790M/L858R mutant with compound 4

Sogabe, S., Kawakita, Y., Igaki, S.

(2013) ACS Med Chem Lett 4: 201-205

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	EDO, W2R

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3W2S \| pdb_00003w2s	Download File View File

EGFR kinase domain with compound4

Sogabe, S., Kawakita, Y., Igaki, S.

(2013) ACS Med Chem Lett 4: 201-205

Released	2013-01-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	SO4, W2R

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3W32 \| pdb_00003w32	Download File View File

EGFR kinase domain complexed with compound 20a

Sogabe, S., Kawakita, Y.

(2013) Bioorg Med Chem 21: 2250-2261

Released	2013-03-06
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	SO4, W32

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3W33 \| pdb_00003w33	Download File View File

EGFR kinase domain complexed with compound 19b

Sogabe, S., Kawakita, Y.

(2013) Bioorg Med Chem 21: 2250-2261

Released	2013-03-06
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	SO4, W19

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4HJO \| pdb_00004hjo	Download File View File

Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib

Park, J.H., Lemmon, M.A.

(2012) Biochem J 448: 417-423

Released	2012-11-14
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AQ4

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4I1Z \| pdb_00004i1z	Download File View File

Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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4I20 \| pdb_00004i20	Download File View File

Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3.34 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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4I21 \| pdb_00004i21	Download File View File

Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3.37 Å
Organisms	Homo sapiens
Macromolecule	ERBB receptor feedback inhibitor 1 (protein) Epidermal growth factor receptor (protein)

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4I22 \| pdb_00004i22	Download File View File

Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	IRE, SO4

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4I23 \| pdb_00004i23	Download File View File

Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	1C9

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4I24 \| pdb_00004i24	Download File View File

Structure of T790M EGFR kinase domain co-crystallized with dacomitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	1C9

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4KRL \| pdb_00004krl	Download File View File

Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0

Ferguson, K.M., Schmitz, K.R.

(2013) Structure 21: 1214-1224

Released	2013-08-28
Method	X-RAY DIFFRACTION 2.849 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Epidermal growth factor receptor (protein) Nanobody/VHH domain 7D12 (protein)
Unique Ligands	IOD, MES, NAG
Unique branched monosaccharides	NAG

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4KRM \| pdb_00004krm	Download File View File

Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5

Ferguson, K.M., Schmitz, K.R.

(2013) Structure 21: 1214-1224

Released	2013-08-28
Method	X-RAY DIFFRACTION 2.655 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Epidermal growth factor receptor (protein) Nanobody/VHH domain 7D12 (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4KRO \| pdb_00004kro	Download File View File

Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR

Ferguson, K.M., Schmitz, K.R.

(2013) Structure 21: 1214-1224

Released	2013-08-28
Method	X-RAY DIFFRACTION 3.054 Å
Organisms	Homo sapiens Lama glama Mus musculus
Macromolecule	Cetuximab heavy chain (protein) Cetuximab light chain (protein) Epidermal growth factor receptor (protein) Nanobody/VHH domain EgA1 (protein)
Unique Ligands	NAG
Unique branched monosaccharides	NAG

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4KRP \| pdb_00004krp	Download File View File

Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR

Ferguson, K.M., Schmitz, K.R.

(2013) Structure 21: 1214-1224

Released	2013-08-28
Method	X-RAY DIFFRACTION 2.823 Å
Organisms	Homo sapiens Lama glama Mus musculus
Macromolecule	Cetuximab heavy chain (protein) Cetuximab light chain (protein) Epidermal growth factor receptor (protein) Nanobody/VHH domain 9G8 (protein)
Unique Ligands	NAG
Unique branched monosaccharides	NAG