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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = AR6

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Search Summary

This query matches 143 Structures.

Refinements

Structure Determination Methodology

experimental (143)

Scientific Name of Source Organism

	Homo sapiens (75)
	Severe acute respiratory syndrome coronavirus 2 (9)
	Escherichia coli (8)
	Thermus thermophilus HB8 (7)
	Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539 (6)
	Legionella pneumophila (6)
	Oryctolagus cuniculus (6)
	Legionella (5)
	Klebsiella pneumoniae (3)
	Drosophila melanogaster (2)

More...

Taxonomy

	Eukaryota (89)
	Bacteria (52)
	Riboviria (10)
	Archaea (2)

Experimental Method

	X-RAY DIFFRACTION (130)
	ELECTRON MICROSCOPY (13)

Polymer Entity Type

	Protein (143)
	DNA (7)
	RNA (5)

Refinement Resolution (Å)

	0.5 - 1.0 (10)
	1.0 - 1.5 (16)
	1.5 - 2.0 (57)
	2.0 - 2.5 (33)
	2.5 - 3.0 (16)
	3.0 - 3.5 (8)
	3.5 - 4.0 (1)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	2005 - 2009 (2)
	2010 - 2014 (16)
	2015 - 2019 (46)
	2020 - 2024 (74)
	2025 - 2029 (5)

Enzyme Classification Name

	Transferases (61)
	Hydrolases (69)

Membrane Protein Annotation

	PDBTM (2)
	OPM (1)
	mpstruc (1)

Symmetry Type

	Asymmetric (113)
	Cyclic (28)
	Dihedral (3)

SCOP Classification

	Alpha and beta proteins (a/b) (22)
	Artifacts (11)
	Alpha and beta proteins (a+b) (9)
	All alpha proteins (1)

AllSelected

1 to 25 of 143 Structures

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2BFQ \| pdb_00002bfq	Download File View File

MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES

Karras, G.I., Buhecha, H.R., Allen, M.D., Pugieux, C., Sait, F., Bycroft, M., Ladurner, A.G.

(2005) EMBO J 24: 1911

Released	2005-01-18
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Archaeoglobus fulgidus
Macromolecule	HYPOTHETICAL PROTEIN AF1521 (protein)
Unique Ligands	AR6

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2WOE \| pdb_00002woe	Download File View File

Crystal Structure of the D97N variant of dinitrogenase reductase- activating glycohydrolase (DRAG) from Rhodospirillum rubrum in complex with ADP-ribose

Berthold, C.L., Wang, H., Nordlund, S., Hogbom, M.

(2009) Proc Natl Acad Sci U S A 106: 14247

Released	2009-08-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Rhodospirillum rubrum
Macromolecule	ADP-RIBOSYL-[DINITROGEN REDUCTASE] GLYCOHYDROLASE (protein)
Unique Ligands	AR6, GOL, MN, TLA

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3PKI \| pdb_00003pki	Download File View File

Human SIRT6 crystal structure in complex with ADP ribose

Pan, P.W., Dong, A., Qiu, W., Loppnau, P., Wang, J., Ravichandran, M., Bochkarev, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Min, J., Edwards, A.M., Structural Genomics Consortium (SGC)

(2011) J Biological Chem 286: 14575-14587

Released	2011-01-26
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Homo sapiens
Macromolecule	NAD-dependent deacetylase sirtuin-6 (protein)
Unique Ligands	AR6, SO4, UNX, ZN

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3Q71 \| pdb_00003q71	Download File View File

Human parp14 (artd8) - macro domain 2 in complex with adenosine-5-diphosphoribose

Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sehic, A., Thorsell, A.G., Tresaugues, L., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2011-01-26
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	AR6

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3SIG \| pdb_00003sig	Download File View File

The X-ray crystal structure of poly(ADP-ribose) glycohydrolase (PARG) bound to ADP-ribose from Thermomonospora curvata

Leys, D., Dunstan, M.S.

(2011) Nature 477: 616-620

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.28 Å
Organisms	Thermomonospora curvata DSM 43183
Macromolecule	poly(ADP-ribose) glycohydrolase (protein)
Unique Ligands	AR6

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3V2B \| pdb_00003v2b	Download File View File

Human poly(adp-ribose) polymerase 15 (ARTD7, BAL3), macro domain 2 in complex with adenosine-5-diphosphoribose

Karlberg, T., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kotenyova, T., Kotzcsh, A., Kraulis, P., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van den berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2011-12-21
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 15 (protein)
Unique Ligands	AR6

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3VFQ \| pdb_00003vfq	Download File View File

Human PARP14 (ARTD8, BAL2) - macro domains 1 and 2 in complex with adenosine-5-diphosphoribose

Karlberg, T., Thorsell, A.G., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Ekblad, T., Weigelt, J., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	AR6

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3X0K \| pdb_00003x0k	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ES-state at 0.97 angstrom resolution

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 0.97 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL

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3X0L \| pdb_00003x0l	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ES-state at 1.00 angstrom resolution

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6

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3X0M \| pdb_00003x0m	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESM-state at reaction time of 3 min

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL, MN, SO4

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3X0N \| pdb_00003x0n	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESM-state at reaction time of 6 min

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.12 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL, MN, SO4

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3X0O \| pdb_00003x0o	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESMM-state at reaction time of 10 min

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.09 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL, MN, SO4

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3X0P \| pdb_00003x0p	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESMM-state at reaction time of 15 min

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.22 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL, MN, SO4

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3X0Q \| pdb_00003x0q	Download File View File

ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESMM-state at reaction time of 20 min

Furuike, Y., Akita, Y., Miyahara, I., Kamiya, N.

(2016) Biochemistry 55: 1801-1812

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.14 Å
Organisms	Thermus thermophilus HB8
Macromolecule	ADP-ribose pyrophosphatase (protein)
Unique Ligands	AR6, GOL, MN, SO4

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3ZGV \| pdb_00003zgv	Download File View File

Structure of human SIRT2 in complex with ADP-ribose

Moniot, S., Steegborn, C.

(2013) J Struct Biol 182: 136

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 (protein)
Unique Ligands	ACT, AR6, GOL, PGE, ZN

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4ABK \| pdb_00004abk	Download File View File

HUMAN PARP14 (ARTD8, BAL2) - MACRO DOMAIN 3 IN COMPLEX WITH ADENOSINE- 5-DIPHOSPHORIBOSE

Karlberg, T., Moche, M., Thorsell, A.G., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Ekblad, T., Weigelt, J., Schuler, H.

(2013) Structure 21: 462

Released	2012-12-19
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	POLY [ADP-RIBOSE] POLYMERASE 14 (protein)
Unique Ligands	AR6

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4B1H \| pdb_00004b1h	Download File View File

Structure of human PARG catalytic domain in complex with ADP-ribose

Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Smith, G., Tucker, J.A., Watson, M.

(2012) PLoS One 7: 50889

Released	2012-12-19
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	POLY(ADP-RIBOSE) GLYCOHYDROLASE (protein)
Unique Ligands	AR6, BME, DTV, GOL, SO4

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4BN4 \| pdb_00004bn4	Download File View File

Structure of human SIRT3 in complex with ADP-ribose

Nguyen, G.T.T., Schaefer, S., Gertz, M., Weyand, M., Steegborn, C.

(2013) Acta Crystallogr D Biol Crystallogr 69: 1423

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (protein)
Unique Ligands	AR6, NA, OP2, ZN

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4BVB \| pdb_00004bvb	Download File View File

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND ADP-RIBOSE

Gertz, M., Weyand, M., Steegborn, C.

(2013) Proc Natl Acad Sci U S A 110: E2772

Released	2013-07-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (protein)
Unique Ligands	AR6, OCZ, ZN

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4BVH \| pdb_00004bvh	Download File View File

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND 2'-O-ACETYL-ADP-RIBOSE

Gertz, M., Weyand, M., Steegborn, C.

(2013) Proc Natl Acad Sci U S A 110: E2772

Released	2013-07-17
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (protein)
Unique Ligands	AR6, CL, EDO, GOL, NA, OAD, OCZ, ZN

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4H0T \| pdb_00004h0t	Download File View File

Crystal structure of Ia-ADPR-actin complex

Tsurumura, T., Oda, M., Nagahama, M., Tsuge, H.

(2013) Proc Natl Acad Sci U S A 110: 4267-4272

Released	2013-02-20
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Clostridium perfringens Oryctolagus cuniculus
Macromolecule	Actin, alpha skeletal muscle (protein) Iota toxin component Ia (protein)
Unique Ligands	AR6, ATP, CA, EDO, LAR, PO4

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4IQY \| pdb_00004iqy	Download File View File

Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2

Jankevicius, G., Hassler, M., Golia, B., Rybin, V., Zacharias, M., Timinszky, G., Ladurner, A.G.

(2013) Nat Struct Mol Biol 20: 508-514

Released	2013-03-06
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	O-acetyl-ADP-ribose deacetylase MACROD2 (protein)
Unique Ligands	AR6, MG

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4L2H \| pdb_00004l2h	Download File View File

Structure of a catalytically inactive PARG in complex with a poly-ADP-ribose fragment

Brassington, A., Dunstan, M.S., Leys, D.

(2013) Nat Commun 4: 2164-2164

Released	2013-07-24
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Tetrahymena thermophila
Macromolecule	Poly(ADP-ribose) glycohydrolase (protein)
Unique Ligands	AR6

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4NA0 \| pdb_00004na0	Download File View File

Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose

Wang, Z., Cheng, Z., Xu, W.

(2014) PLoS One 9: e86010-e86010

Released	2014-01-29
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Mus musculus
Macromolecule	Poly(ADP-ribose) glycohydrolase (protein)
Unique Ligands	AR6, IOD

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4P5F \| pdb_00004p5f	Download File View File

The crystal structure of type III effector protein XopQ complexed with adenosine diphosphate ribose

Yu, S., Hwang, I., Rhee, S.

(2014) Proteins 82: 2910-2914

Released	2014-08-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Xanthomonas oryzae pv. oryzae KACC 10331
Macromolecule	Inosine-uridine nucleoside N-ribohydrolase (protein)
Unique Ligands	AR6, CA

1 to 25 of 143 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2BFQ | pdb_00002bfq

2WOE | pdb_00002woe

3PKI | pdb_00003pki

3Q71 | pdb_00003q71

3SIG | pdb_00003sig

3V2B | pdb_00003v2b

3VFQ | pdb_00003vfq

3X0K | pdb_00003x0k

3X0L | pdb_00003x0l

3X0M | pdb_00003x0m

3X0N | pdb_00003x0n

3X0O | pdb_00003x0o

3X0P | pdb_00003x0p

3X0Q | pdb_00003x0q

3ZGV | pdb_00003zgv

4ABK | pdb_00004abk

4B1H | pdb_00004b1h

4BN4 | pdb_00004bn4

4BVB | pdb_00004bvb

4BVH | pdb_00004bvh

4H0T | pdb_00004h0t

4IQY | pdb_00004iqy

4L2H | pdb_00004l2h

4NA0 | pdb_00004na0

4P5F | pdb_00004p5f