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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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Search Summary

This query matches 23 Structures.

Refinements

Structure Determination Methodology

experimental (23)

Scientific Name of Source Organism

	Homo sapiens (22)
	Mus musculus (1)

Taxonomy

Eukaryota (23)

Experimental Method

X-RAY DIFFRACTION (23)

Polymer Entity Type

Protein (23)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (11)
	2.5 - 3.0 (4)
	3.0 - 3.5 (4)

Release Date

	2005 - 2009 (1)
	2015 - 2019 (6)
	2020 - 2024 (16)

Enzyme Classification Name

Transferases (20)

Symmetry Type

	Cyclic (18)
	Asymmetric (5)

SCOP Classification

	Alpha and beta proteins (a+b) (8)
	All beta proteins (1)
	Small proteins (2)

AllSelected

1 to 23 of 23 Structures

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1SHX \| pdb_00001shx	Download File View File

Ephrin A5 ligand structure

Himanen, J.P., Barton, W.A., Nikolov, D.B., Jeffrey, P.D.

(2005) J Biological Chem 280: 26526-26532

Released	2005-04-19
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	Ephrin-A5 (protein)
Unique branched monosaccharides	NAG

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5VZ3 \| pdb_00005vz3	Download File View File

Growth Factor Crystal Structure at 1.97 Angstrom Resolution

Lakshminarasimhan, D., White, A., Suto, R.K.

(2017) Nature 550: 255-259

Released	2017-09-27
Method	X-RAY DIFFRACTION 1.97 Å
Organisms	Homo sapiens
Macromolecule	Growth/differentiation factor 15 (protein)

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5VZ4 \| pdb_00005vz4	Download File View File

Receptor-growth factor crystal structure at 2.20 Angstrom resolution

Lakshminarasimhan, D., White, A., Suto, R.K.

(2017) Nature 550: 255-259

Released	2017-09-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	GDNF family receptor alpha-like (protein) Growth/differentiation factor 15 (protein)
Unique Ligands	BR, EDO, SO4

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6DUK \| pdb_00006duk	Download File View File

EGFR with an allosteric inhibitor

Park, E., Eck, M.J.

(2019) Cancer Discov 9: 926-943

Released	2019-06-05
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG

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6P1D \| pdb_00006p1d	Download File View File

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1

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6P1L \| pdb_00006p1l	Download File View File

Crystal structure of EGFR in complex with EAI045

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG

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6P8Q \| pdb_00006p8q	Download File View File

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

Yun, C.H., Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AMP, ANP, EDO, MG, O57

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6WA2 \| pdb_00006wa2	Download File View File

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CL, TOV

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6WAK \| pdb_00006wak	Download File View File

A crystal structure of EGFR(T790M/V948R) in complex with LN3754

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, TQA

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6WXN \| pdb_00006wxn	Download File View File

EGFR(T790M/V948R) in complex with LN3844

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-05-19
Method	X-RAY DIFFRACTION 1.76 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, CL, MG, UEJ

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

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7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXQ \| pdb_00007jxq	Download File View File

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Cancer 3: 402-417

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7JXW \| pdb_00007jxw	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1H \| pdb_00007k1h	Download File View File

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 2.602 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1I \| pdb_00007k1i	Download File View File

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 3.202 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7LG8 \| pdb_00007lg8	Download File View File

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.93 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8RC, VNS

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7LTX \| pdb_00007ltx	Download File View File

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Bioorg Med Chem Lett 68: 128718-128718

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, YFA