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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Shin, B.H."

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Search Summary

This query matches 9 Structures.

Refinements

Structure Determination Methodology

experimental (9)

Scientific Name of Source Organism

Homo sapiens (9)

Taxonomy

Eukaryota (9)

Experimental Method

X-RAY DIFFRACTION (9)

Polymer Entity Type

Protein (9)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (5)
	2.5 - 3.0 (1)

Release Date

	2015 - 2019 (4)
	2020 - 2024 (5)

Enzyme Classification Name

Transferases (9)

Symmetry Type

	Cyclic (7)
	Asymmetric (2)

SCOP Classification

Alpha and beta proteins (a+b) (7)

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1 to 9 of 9 Structures

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Explore in 3D

6DUK \| pdb_00006duk	Download File View File

EGFR with an allosteric inhibitor

Park, E., Eck, M.J.

(2019) Cancer Discov 9: 926-943

Released	2019-06-05
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG

Explore in 3D

6P1D \| pdb_00006p1d	Download File View File

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1

Explore in 3D

6P1L \| pdb_00006p1l	Download File View File

Crystal structure of EGFR in complex with EAI045

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG

Explore in 3D

6P8Q \| pdb_00006p8q	Download File View File

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

Yun, C.H., Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AMP, ANP, EDO, MG, O57

Explore in 3D

6WA2 \| pdb_00006wa2	Download File View File

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CL, TOV

Explore in 3D

6WAK \| pdb_00006wak	Download File View File

A crystal structure of EGFR(T790M/V948R) in complex with LN3754

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, TQA

Explore in 3D

6WXN \| pdb_00006wxn	Download File View File

EGFR(T790M/V948R) in complex with LN3844

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-05-19
Method	X-RAY DIFFRACTION 1.76 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, CL, MG, UEJ

Explore in 3D

7JXQ \| pdb_00007jxq	Download File View File

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Cancer 3: 402-417

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

Explore in 3D

7LTX \| pdb_00007ltx	Download File View File

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Bioorg Med Chem Lett 68: 128718-128718

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, YFA

1 to 9 of 9 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

6DUK | pdb_00006duk

EGFR with an allosteric inhibitor

6P1D | pdb_00006p1d

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

6P1L | pdb_00006p1l

Crystal structure of EGFR in complex with EAI045

6P8Q | pdb_00006p8q

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

6WA2 | pdb_00006wa2

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

6WAK | pdb_00006wak

A crystal structure of EGFR(T790M/V948R) in complex with LN3754

6WXN | pdb_00006wxn

EGFR(T790M/V948R) in complex with LN3844

7JXQ | pdb_00007jxq

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

7LTX | pdb_00007ltx

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

6DUK | pdb_00006duk

6P1D | pdb_00006p1d

6P1L | pdb_00006p1l

6P8Q | pdb_00006p8q

6WA2 | pdb_00006wa2

6WAK | pdb_00006wak

6WXN | pdb_00006wxn

7JXQ | pdb_00007jxq

7LTX | pdb_00007ltx