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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Hanan, E.J."

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Search Summary

This query matches 55 Structures.

Refinements

Structure Determination Methodology

experimental (55)

Scientific Name of Source Organism

	Homo sapiens (43)
	Danio rerio (6)
	Mus musculus (2)
	Mycobacterium tuberculosis (2)
	Escherichia coli (1)
	Staphylococcus aureus (1)

Taxonomy

	Eukaryota (51)
	Bacteria (4)

Experimental Method

X-RAY DIFFRACTION (55)

Polymer Entity Type

Protein (55)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (10)
	2.0 - 2.5 (15)
	2.5 - 3.0 (22)
	3.0 - 3.5 (7)

Release Date

	2005 - 2009 (8)
	2010 - 2014 (11)
	2015 - 2019 (28)
	2020 - 2024 (8)

Enzyme Classification Name

	Transferases (51)
	Oxidoreductases (3)

Membrane Protein Annotation

	OPM (1)
	PDBTM (1)
	mpstruc (1)

Symmetry Type

	Asymmetric (52)
	Cyclic (3)

SCOP Classification

	Alpha and beta proteins (a+b) (44)
	Artifacts (3)

AllSelected

1 to 25 of 55 Structures

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3D14 \| pdb_00003d14	Download File View File

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea

Elling, R.A., Baskaran, S., Allen, D.A., Oslob, J.D., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 4880-4884

Released	2008-08-26
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	serine/threonine kinase 6 (protein)
Unique Ligands	AK1

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3D15 \| pdb_00003d15	Download File View File

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]

Elling, R.A., Bui, M., Allen, D.A., Oslob, J.D., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 4880-4884

Released	2009-05-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	serine/threonine kinase 6 (protein)
Unique Ligands	AK2

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3DB6 \| pdb_00003db6	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902

Elling, R.A., Fucini, R.V., Zhu, J., Barr, K.J., Romanowski, M.J.

(2008) Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 686-691

Released	2008-08-19
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase 1 (protein)
Unique Ligands	FRS

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3DB8 \| pdb_00003db8	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 041

Elling, R.A., Hanan, E.J., Lew, W., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 5186-5189

Released	2008-10-07
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase 1 (protein)
Unique Ligands	1FR

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3DBC \| pdb_00003dbc	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 257

Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 5648-5652

Released	2008-10-07
Method	X-RAY DIFFRACTION 3.35 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase 1 (protein)
Unique Ligands	2FR

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3DBD \| pdb_00003dbd	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094

Elling, R.A., Barr, K.J., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 5648-5652

Released	2008-10-07
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase 1 (protein)
Unique Ligands	3FR

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3DBE \| pdb_00003dbe	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557

Elling, R.A., Barr, K.J., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 5648-5652

Released	2008-10-07
Method	X-RAY DIFFRACTION 3.32 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase 1 (protein)
Unique Ligands	4FR

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3DBF \| pdb_00003dbf	Download File View File

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562

Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.

(2008) Bioorg Med Chem Lett 18: 5648-5652

Released	2008-10-07
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Danio rerio
Macromolecule	Polo-like kinase (protein)
Unique Ligands	5FR

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4EHZ \| pdb_00004ehz	Download File View File

The Jak1 kinase domain in complex with inhibitor

Lupardus, P.J., Steffek, M.

(2012) J Med Chem 55: 6176-6193

Released	2012-07-04
Method	X-RAY DIFFRACTION 2.174 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK1 (protein)
Unique Ligands	EDO, JAK

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4EI4 \| pdb_00004ei4	Download File View File

JAK1 kinase (JH1 domain) in complex with compound 20

Eigenbrot, C., Steffek, M.

(2012) J Med Chem 55: 6176-6193

Released	2012-07-04
Method	X-RAY DIFFRACTION 2.22 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK1 (protein)
Unique Ligands	0Q2

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4F08 \| pdb_00004f08	Download File View File

Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Murray, J.M.

(2012) J Med Chem 55: 6176-6193

Released	2012-07-04
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK2 (protein)
Unique Ligands	1RS

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4F09 \| pdb_00004f09	Download File View File

Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Murray, J.M.

(2012) J Med Chem 55: 6176-6193

Released	2012-07-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK2 (protein)
Unique Ligands	JAK

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4HGE \| pdb_00004hge	Download File View File

JAK2 kinase (JH1 domain) in complex with compound 8

Eigenbrot, C., Ultsch, M.

(2012) J Med Chem 55: 10090-10107

Released	2012-10-24
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK2 (protein)
Unique Ligands	15V

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4RJ3 \| pdb_00004rj3	Download File View File

CDK2 with EGFR inhibitor compound 8

Eigenbrot, C., Yin, J.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 1.63 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	3QS, ACT

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4RJ4 \| pdb_00004rj4	Download File View File

EGFR kinase (T790M/L858R) with inhibitor compound 6

Eigenbrot, C., Yu, C.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 2.78 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	3QW

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4RJ5 \| pdb_00004rj5	Download File View File

EGFR kinase (T790M/L858R) with inhibitor compound 5

Eigenbrot, C., Yu, C.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	3QY

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4RJ6 \| pdb_00004rj6	Download File View File

EGFR kinase (T790M/L858R) with inhibitor compound 4

Eigenbrot, C., Yu, C.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	3R0, SO4

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4RJ7 \| pdb_00004rj7	Download File View File

EGFR kinase (T790M/L858R) with inhibitor compound 1

Eigenbrot, C., Yu, C.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	3R1, SO4

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4RJ8 \| pdb_00004rj8	Download File View File

EGFR kinase (T790M/L858R) with inhibitor compound 8

Eigenbrot, C., Yu, C.

(2014) J Med Chem 57: 10176-10191

Released	2014-11-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	3QS, SO4

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5C8K \| pdb_00005c8k	Download File View File

EGFR kinase domain mutant "TMLR" with compound 1

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4YV

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5C8M \| pdb_00005c8m	Download File View File

EGFR kinase domain mutant "TMLR" with compound 17

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4YW

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5C8N \| pdb_00005c8n	Download File View File

EGFR kinase domain mutant "TMLR" with compound 23

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.401 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4YX, SO4

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5CAL \| pdb_00005cal	Download File View File

EGFR kinase domain mutant "TMLR" with compound 24

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4Z8

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5CAN \| pdb_00005can	Download File View File

EGFR kinase domain mutant "TMLR" with compound 27

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4ZB, SO4

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5CAO \| pdb_00005cao	Download File View File

EGFR kinase domain mutant "TMLR" with compound 29

Eigenbrot, C., Yu, C.

(2015) J Med Chem 58: 8877-8895

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	4ZG

1 to 25 of 55 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

3D14 | pdb_00003d14

3D15 | pdb_00003d15

3DB6 | pdb_00003db6

3DB8 | pdb_00003db8

3DBC | pdb_00003dbc

3DBD | pdb_00003dbd

3DBE | pdb_00003dbe

3DBF | pdb_00003dbf

4EHZ | pdb_00004ehz

4EI4 | pdb_00004ei4

4F08 | pdb_00004f08

4F09 | pdb_00004f09

4HGE | pdb_00004hge

4RJ3 | pdb_00004rj3

4RJ4 | pdb_00004rj4

4RJ5 | pdb_00004rj5

4RJ6 | pdb_00004rj6

4RJ7 | pdb_00004rj7

4RJ8 | pdb_00004rj8

5C8K | pdb_00005c8k

5C8M | pdb_00005c8m

5C8N | pdb_00005c8n

5CAL | pdb_00005cal

5CAN | pdb_00005can

5CAO | pdb_00005cao