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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Greasley, S."

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Search Summary

This query matches 30 Structures.

Refinements

Structure Determination Methodology

experimental (30)

Scientific Name of Source Organism

	Homo sapiens (28)
	Rattus norvegicus (2)
	synthetic construct (2)

Taxonomy

	Eukaryota (30)
	other sequences (2)

Experimental Method

X-RAY DIFFRACTION (30)

Polymer Entity Type

Protein (30)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (8)
	2.0 - 2.5 (10)
	2.5 - 3.0 (9)
	3.0 - 3.5 (1)

Release Date

	1995 - 1999 (2)
	2005 - 2009 (6)
	2010 - 2014 (13)
	2015 - 2019 (1)
	2020 - 2024 (6)
	2025 - 2029 (2)

Enzyme Classification Name

	Transferases (18)
	Isomerases (6)
	Lyases (3)
	Hydrolases (2)
	Oxidoreductases (1)

Symmetry Type

	Asymmetric (26)
	Cyclic (6)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (12)
	All beta proteins (7)
	All alpha proteins (5)
	Alpha and beta proteins (a/b) (2)

AllSelected

1 to 25 of 30 Structures

Page 1 of 2

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1RRF \| pdb_00001rrf	Download File View File

NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM

Greasley, S.E., Jhoti, H., Bax, B.

(1995) Nat Struct Biol 2: 797-806

Released	1996-06-20
Method	X-RAY DIFFRACTION 3 Å
Organisms	Rattus norvegicus
Macromolecule	RAT ADP-RIBOSYLATION FACTOR-1 (protein)
Unique Ligands	GDP, MG

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1RRG \| pdb_00001rrg	Download File View File

NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, DIMERIC CRYSTAL FORM

Greasley, S.E., Jhoti, H., Bax, B.

(1995) Nat Struct Biol 2: 797-806

Released	1996-06-20
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Rattus norvegicus
Macromolecule	RAT ADP-RIBOSYLATION FACTOR-1 (protein)
Unique Ligands	GDP, MG

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3F7B \| pdb_00003f7b	Download File View File

Crystal Structure of soluble domain of CA4 in complex with small molecule.

Greasley, S.E., Ferre, R.A.A., Pauly, T.A., Paz, R.

(2010) Bioorg Med Chem 18: 3307-3319

Released	2009-09-22
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 4 (protein)
Unique Ligands	AG5, ZN

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3F7U \| pdb_00003f7u	Download File View File

Crystal Structure of soluble domain of CA4 in complex with small molecule.

Pauly, T.A., Ferre, R.A.A., Greasley, S.E., Paz, R.

(2010) Bioorg Med Chem 18: 3307-3319

Released	2009-09-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 4 (protein)
Unique Ligands	AG4, ZN

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3FW3 \| pdb_00003fw3	Download File View File

Crystal Structure of soluble domain of CA4 in complex with Dorzolamide

Greasley, S.E., Ferre, R.A.A., Paz, R., Wickersham, J.

(2010) Bioorg Med Chem 18: 3307-3319

Released	2009-12-01
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 4 (protein)
Unique Ligands	ETS, GLC, SO4, ZN

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3I6C \| pdb_00003i6c	Download File View File

Structure-Based Design of Novel PIN1 Inhibitors (II)

Greasley, S.E., Ferre, R.A.

(2010) Bioorg Med Chem Lett 20: 2210-2214

Released	2010-04-21
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)
Unique Ligands	GIA

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3IK8 \| pdb_00003ik8	Download File View File

Structure-Based Design of Novel PIN1 Inhibitors (I)

Matthews, D., Greasley, S., Ferre, R.A., Parge, H.

(2009) Bioorg Med Chem Lett 19: 5613-5616

Released	2009-09-22
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)

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3IKD \| pdb_00003ikd	Download File View File

Structure-Based Design of Novel PIN1 Inhibitors (I)

Matthews, D., Greasley, S., Ferre, R., Parge, H.

(2009) Bioorg Med Chem Lett 19: 5613-5616

Released	2009-09-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)
Unique Ligands	J9Z

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3IKG \| pdb_00003ikg	Download File View File

Structure-Based Design of Novel PIN1 Inhibitors (I)

Parge, H., Ferre, R.A., Greasley, S., Matthews, D.

(2009) Bioorg Med Chem Lett 19: 5613-5616

Released	2009-09-22
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)
Unique Ligands	J8Z

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3JYJ \| pdb_00003jyj	Download File View File

Structure-Based Design of Novel PIN1 Inhibitors (II)

Greasley, S.E., Ferre, R.A.

(2010) Bioorg Med Chem Lett 20: 2210-2214

Released	2010-04-07
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)
Unique Ligands	JZI

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3OAW \| pdb_00003oaw	Download File View File

4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors

Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.

(2010) Bioorg Med Chem Lett 20: 6096-6099

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	OAW

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3PRE \| pdb_00003pre	Download File View File

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.

(2011) Bioorg Med Chem Lett 21: 1270-1274

Released	2011-02-09
Method	X-RAY DIFFRACTION 2.91 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3RE

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3PRZ \| pdb_00003prz	Download File View File

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.

(2011) Bioorg Med Chem Lett 21: 1270-1274

Released	2011-02-09
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3RZ

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3PS6 \| pdb_00003ps6	Download File View File

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Knighton, D.R., Greasley, S.E., Rogers, C.M.-L.

(2011) Bioorg Med Chem Lett 21: 1270-1274

Released	2011-02-09
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	3PS

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3RWP \| pdb_00003rwp	Download File View File

Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)

Greasley, S.E., Hickey, M., Ferre, R.-A., Krauss, M., Cronin, C.

(2011) J Med Chem 54: 8490-8500

Released	2011-11-16
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	3-phosphoinositide-dependent protein kinase 1 (protein)
Unique Ligands	ABQ, GOL, SO4

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3RWQ \| pdb_00003rwq	Download File View File

Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)

Kazmirski, S., Kohls, D.

(2011) J Med Chem 54: 8490-8500

Released	2011-11-16
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	3-phosphoinositide-dependent protein kinase 1 (protein)
Unique Ligands	3RW, GOL, SO4

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3SC1 \| pdb_00003sc1	Download File View File

Novel Isoquinolone PDK1 Inhibitors Discovered through Fragment-Based Lead Discovery

Greasley, S.E., Ferre, R.-A., Krauss, M., Cronin, C.

(2011) J Comput Aided Mol Des 25: 689-698

Released	2011-10-26
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	3-phosphoinositide-dependent protein kinase 1 (protein)
Unique Ligands	3S1, GOL, SO4

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4FA6 \| pdb_00004fa6	Download File View File

Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR

Pannifer, A., Greasley, S.E.

(2012) Bioorg Med Chem Lett 22: 5098-5103

Released	2013-04-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	0TA

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4FAD \| pdb_00004fad	Download File View File

Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR

Greasley, S.E., Knighton, D.R., LaFleur Rogers, C.M.

(2012) Bioorg Med Chem Lett 22: 5098-5103

Released	2013-04-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	0TB

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4JPG \| pdb_00004jpg	Download File View File

2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators

Greasley, S.E., Hickey, M., Phonephaly, H., Cronin, C.

(2013) Bioorg Med Chem Lett 23: 3358-3363

Released	2013-05-22
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	1OX, FBP

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4TYO \| pdb_00004tyo	Download File View File

PPIase in complex with a non-phosphate small molecule inhibitor.

Greasley, S.E., Ferre, R.A.

(2014) Bioorg Med Chem Lett 24: 4187-4191

Released	2014-08-20
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (protein)
Unique Ligands	39X, GOL

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5WHR \| pdb_00005whr	Download File View File

Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.

Greasley, S.E., Kaiser, S.E., Feng, J.L., Stewart, A.

(2017) J Med Chem 60: 9617-9629

Released	2017-12-27
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens
Macromolecule	Indoleamine 2,3-dioxygenase 1 (protein)
Unique Ligands	AOJ, HEM

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6WF3 \| pdb_00006wf3	Download File View File

Crystal structure of human Naa50 in complex with a cofactor derived inhibitor (compound 1)

Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.

(2020) ACS Med Chem Lett 11: 1175-1184

Released	2020-07-01
Method	X-RAY DIFFRACTION 2.291 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	ACE-MET-LEU-GLY-PRO-NH2 (protein) N-alpha-acetyltransferase 50 (protein)
Unique Ligands	COA

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6WF5 \| pdb_00006wf5	Download File View File

Crystal structure of human Naa50 in complex with a truncated cofactor derived inhibitor (compound 2)

Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.

(2020) ACS Med Chem Lett 11: 1175-1184

Released	2020-07-01
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	ACE-MET-LEU-GLY-PRO-NH2 (protein) N-alpha-acetyltransferase 50 (protein)
Unique Ligands	U44