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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Di Fiore, A."

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Search Summary

This query matches 63 Structures.

Refinements

Structure Determination Methodology

experimental (63)

Scientific Name of Source Organism

	Homo sapiens (42)
	Bos taurus (13)
	Lithobates pipiens (3)
	Burkholderia pseudomallei (1)
	Saccharolobus solfataricus (1)
	Sulfurihydrogenibium azorense (1)
	Sulfurihydrogenibium sp. YO3AOP1 (1)
	Trichomonas vaginalis (1)

Taxonomy

	Eukaryota (59)
	Bacteria (3)
	Archaea (1)

Experimental Method

X-RAY DIFFRACTION (63)

Polymer Entity Type

Protein (63)

Refinement Resolution (Å)

	1.0 - 1.5 (6)
	1.5 - 2.0 (41)
	2.0 - 2.5 (14)
	2.5 - 3.0 (2)

Release Date

	2000 - 2004 (6)
	2005 - 2009 (24)
	2010 - 2014 (7)
	2015 - 2019 (18)
	2020 - 2024 (8)

Enzyme Classification Name

	Lyases (58)
	Hydrolases (17)

Symmetry Type

	Asymmetric (46)
	Cyclic (17)
	Dihedral (1)

SCOP Classification

	All beta proteins (39)
	Alpha and beta proteins (a+b) (17)
	Artifacts (6)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 63 Structures

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1N1X \| pdb_00001n1x	Download File View File

Crystal Structure Analysis of the monomeric [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] Bovine seminal ribonuclease

Sica, F., Di Fiore, A., Zagari, A., Mazzarella, L.

(2003) Proteins 52: 263-271

Released	2003-08-26
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Bos taurus
Macromolecule	Ribonuclease, seminal (protein)

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1N3Z \| pdb_00001n3z	Download File View File

Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state

Sica, F., Di Fiore, A., Zagari, A., Mazzarella, L.

(2003) Proteins 52: 263-271

Released	2003-08-26
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Bos taurus
Macromolecule	Ribonuclease, seminal (protein)
Unique Ligands	ADN, U3P

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1R3M \| pdb_00001r3m	Download File View File

Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease

Berisio, R., Sica, F., De Lorenzo, C., Di Fiore, A., Piccoli, R., Zagari, A., Mazzarella, L.

(2003) FEBS Lett 554: 105-110

Released	2003-11-18
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus
Macromolecule	Ribonuclease, seminal (protein)
Unique Ligands	PO4

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1TQ9 \| pdb_00001tq9	Download File View File

Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE

Sica, F., Di Fiore, A., Merlino, A., Mazzarella, L.

(2004) J Biological Chem 279: 36753-36760

Released	2004-09-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus
Macromolecule	Ribonuclease, seminal (protein)
Unique Ligands	CPA

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1Y92 \| pdb_00001y92	Download File View File

Crystal structure of the P19A/N67D Variant Of Bovine seminal Ribonuclease

Picone, D., Di Fiore, A., Ercole, C., Franzese, M., Sica, F., Tomaselli, S., Mazzarella, L.

(2005) J Biological Chem 280: 13771-13778

Released	2004-12-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus
Macromolecule	Seminal ribonuclease (protein)

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1Y94 \| pdb_00001y94	Download File View File

Crystal structure of the G16S/N17T/P19A/S20A/N67D Variant Of Bovine seminal Ribonuclease

Picone, D., Di Fiore, A., Ercole, C., Franzese, M., Sica, F., Tomaselli, S., Mazzarella, L.

(2005) J Biological Chem 280: 13771-13778

Released	2004-12-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus
Macromolecule	Seminal ribonuclease (protein)

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1YV4 \| pdb_00001yv4	Download File View File

X-ray structure of M23L onconase at 100K

Merlino, A., Mazzarella, L., Carannante, A., Di Fiore, A., Di Donato, A., Notomista, E., Sica, F.

(2005) J Biological Chem 280: 17953-17960

Released	2005-03-01
Method	X-RAY DIFFRACTION 1.51 Å
Organisms	Lithobates pipiens
Macromolecule	P-30 protein (protein)
Unique Ligands	SO4

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1YV6 \| pdb_00001yv6	Download File View File

X-ray structure of M23L onconase at 298K

Merlino, A., Mazzarella, L., Carannante, A., Di Fiore, A., Di Donato, A., Notomista, E., Sica, F.

(2005) J Biological Chem 280: 17953-17960

Released	2005-03-01
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Lithobates pipiens
Macromolecule	P-30 protein (protein)
Unique Ligands	SO4

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1YV7 \| pdb_00001yv7	Download File View File

X-ray structure of (C87S,des103-104) onconase

Merlino, A., Mazzarella, L., Carannante, A., Di Fiore, A., Di Donato, A., Notomista, E., Sica, F.

(2005) J Biological Chem 280: 17953-17960

Released	2005-03-01
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Lithobates pipiens
Macromolecule	P-30 protein (protein)
Unique Ligands	SO4

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1ZE8 \| pdb_00001ze8	Download File View File

Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor

Menchise, V., De Simone, G., Alterio, V., Di Fiore, A., Pedone, C., Scozzafava, A., Supuran, C.T.

(2005) J Med Chem 48: 5721-5727

Released	2005-10-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase II (protein)
Unique Ligands	GOL, HGB, PIU, ZN

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2AW1 \| pdb_00002aw1	Download File View File

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib

Di Fiore, A., Pedone, C., D'Ambrosio, K., Scozzafava, A., De Simone, G., Supuran, C.T.

(2006) Bioorg Med Chem Lett 16: 437-442

Released	2006-07-04
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase II (protein)
Unique Ligands	COX, GOL, HGB, ZN

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2GD8 \| pdb_00002gd8	Download File View File

Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate

De Simone, G., Di Fiore, A.

(2006) J Med Chem 49: 7683-7696

Released	2007-02-06
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	CL, MBO, PO1, ZN

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2HD6 \| pdb_00002hd6	Download File View File

Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.

De Simone, G., Vitale, R.M., Di Fiore, A., Pedone, C.

(2006) J Med Chem 49: 5544-5551

Released	2006-10-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	BOS, CL, GOL, MBO, ZN

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2HL4 \| pdb_00002hl4	Download File View File

Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative

Di Fiore, A., Supuran, C.T., Winum, J.-Y., Montero, J.-L., Pedone, C., Scozzafava, A., De Simone, G.

(2007) Bioorg Med Chem Lett 17: 1726-1731

Released	2007-05-22
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	BO1, CL, GOL, MBO, ZN

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2HNC \| pdb_00002hnc	Download File View File

Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor.

Menchise, V., Di Fiore, A., De Simone, G.

(2006) Bioorg Med Chem Lett 16: 6204-6208

Released	2006-12-19
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	1SA, GOL, MBO, ZN

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3BCM \| pdb_00003bcm	Download File View File

Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase

Merlino, A., Ercole, C., Picone, D., Pizzo, E., Mazzarella, L., Sica, F.

(2008) J Mol Biology 376: 427-437

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus
Macromolecule	Seminal ribonuclease (protein)
Unique Ligands	PO4

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3BCO \| pdb_00003bco	Download File View File

Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase

Merlino, A., Ercole, C., Picone, D., Pizzo, E., Mazzarella, L., Sica, F.

(2008) J Mol Biology 376: 427-437

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus
Macromolecule	Seminal ribonuclease (protein)

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3BCP \| pdb_00003bcp	Download File View File

Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase

Merlino, A., Ercole, C., Picone, D., Pizzo, E., Mazzarella, L., Sica, F.

(2008) J Mol Biology 376: 427-437

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Bos taurus
Macromolecule	Seminal ribonuclease (protein)

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3BET \| pdb_00003bet	Download File View File

Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution

Di Fiore, A., De Simone, G.

(2008) J Med Chem 51: 1295-1308

Released	2008-10-07
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	CTF, GOL, ZN

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3C7P \| pdb_00003c7p	Download File View File

Crystal structure of human carbonic anhydrase II in complex with STX237

Di Fiore, A., De Simone, G.

(2008) Mol Cancer Ther 7: 2435-2444

Released	2009-01-13
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	CL, GOL, MBO, POF, ZN

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3CAJ \| pdb_00003caj	Download File View File

Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide

Di Fiore, A., De Simone, G.

(2008) Bioorg Med Chem Lett 18: 2669-2674

Released	2008-04-08
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	CL, EZL, GOL, MBO, ZN

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3CZV \| pdb_00003czv	Download File View File

Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide

Di Fiore, A., De Simone, G.

(2008) Proteins 74: 164-175

Released	2008-07-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 13 (protein)
Unique Ligands	AZM, GOL, ZN

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3D0N \| pdb_00003d0n	Download File View File

Crystal structure of human carbonic anhydrase XIII

Di Fiore, A., De Simone, G.

(2008) Proteins 74: 164-175

Released	2008-07-29
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 13 (protein)
Unique Ligands	ACT, GOL, ZN

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3F3X \| pdb_00003f3x	Download File View File

Crystal structure of the transcriptional regulator BldR from Sulfolobus Solfataricus

Di Fiore, A., De Simone, G.

(2009) J Mol Biology 388: 559-569

Released	2009-05-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Saccharolobus solfataricus
Macromolecule	Transcriptional regulator, marR family, putative (protein)
Unique Ligands	SO4