EZL

6-ethoxy-1,3-benzothiazole-2-sulfonamide

Created: 2008-02-21
Last modified:  2020-06-05

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Chemical Details

Formal Charge0
Atom Count26
Chiral Atom Count0
Bond Count27
Aromatic Bond Count10
2D diagram of EZL
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Chemical Component Summary

Name6-ethoxy-1,3-benzothiazole-2-sulfonamide
SynonymsEthoxzolamide
Systematic Name (OpenEye OEToolkits)6-ethoxy-1,3-benzothiazole-2-sulfonamide
FormulaC9 H10 N2 O3 S2
Molecular Weight258.317
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04O=S(=O)(c1nc2ccc(OCC)cc2s1)N
SMILESCACTVS3.341CCOc1ccc2nc(sc2c1)[S](N)(=O)=O
SMILESOpenEye OEToolkits1.5.0CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
Canonical SMILESCACTVS3.341 CCOc1ccc2nc(sc2c1)[S](N)(=O)=O
Canonical SMILESOpenEye OEToolkits1.5.0 CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
InChIInChI1.03 InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKeyInChI1.03 OUZWUKMCLIBBOG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank IDDB00311 
NameEthoxzolamide
Groups withdrawn
DescriptionEthoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.
Synonyms
  • Ethoxazolamide
  • Ethoxzolamide
  • Ethoxyzolamide
  • 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
IndicationFor use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
Categories
  • Amides
  • Benzothiazoles
  • Carbonic Anhydrase Inhibitors
  • Diuretics
  • Enzyme Inhibitors
CAS number452-35-7

Drug Targets

NameTarget SequencePharmacological ActionActions
Carbonic anhydrase 2MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...unknowninhibitor
Carbonic anhydrase 4MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR...unknowninhibitor
Carbonic anhydrase 7MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLE...unknowninhibitor
Carbonic anhydrase 1MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV...unknowninhibitor
Carbonic anhydrase 3MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVS...unknowninhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL18
PubChem 3295
ChEMBL CHEMBL18
ChEBI CHEBI:101096