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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Couttet, P."

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Severe acute respiratory syndrome coronavirus 2 (10)
	Escherichia coli (4)
	Thermus aquaticus (1)

Taxonomy

	Riboviria (10)
	Bacteria (5)

Experimental Method

X-RAY DIFFRACTION (15)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (6)
	2.0 - 2.5 (6)
	2.5 - 3.0 (2)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (4)
	2010 - 2014 (1)
	2020 - 2024 (10)

Enzyme Classification Name

	Ligases (5)
	Hydrolases (10)

Symmetry Type

	Cyclic (15)
	Asymmetric (1)

SCOP Classification

	Alpha and beta proteins (a/b) (5)
	All beta proteins (8)
	Alpha and beta proteins (a+b) (4)

AllSelected

1 to 15 of 15 Structures

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1CQI \| pdb_00001cqi	Download File View File

Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase

Joyce, M.A., Fraser, M.E., James, M.N.G., Bridger, W.A., Wolodko, W.T.

(2000) Biochemistry 39: 17-25

Released	2000-01-07
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (SUCCINYL-COA SYNTHETASE ALPHA CHAIN) (protein) PROTEIN (SUCCINYL-COA SYNTHETASE BETA CHAIN) (protein)
Unique Ligands	ADP, COA, MG, PO4

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1CQJ \| pdb_00001cqj	Download File View File

CRYSTAL STRUCTURE OF DEPHOSPHORYLATED E. COLI SUCCINYL-COA SYNTHETASE

Joyce, M.A., Fraser, M.E., James, M.N.G., Bridger, W.A., Wolodko, W.T.

(2000) Biochemistry 39: 17-25

Released	2000-01-10
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli
Macromolecule	SUCCINYL-COA SYNTHETASE ALPHA CHAIN (protein) SUCCINYL-COA SYNTHETASE BETA CHAIN (protein)
Unique Ligands	COA, PO4

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1JKJ \| pdb_00001jkj	Download File View File

E. coli SCS

Fraser, M.E.

(2002) Biochemistry 41: 537-546

Released	2002-01-30
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Escherichia coli
Macromolecule	succinyl-CoA synthetase alpha subunit (protein) succinyl-CoA synthetase beta subunit (protein)
Unique Ligands	COA, GOL, PO4, SO4

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1JLL \| pdb_00001jll	Download File View File

Crystal Structure Analysis of the E197betaA Mutant of E. coli SCS

Fraser, M.E.

(2002) Biochemistry 41: 537-546

Released	2002-01-30
Method	X-RAY DIFFRACTION 2.69 Å
Organisms	Escherichia coli
Macromolecule	succinyl-CoA synthetase alpha subunit (protein) succinyl-CoA synthetase beta subunit (protein)
Unique Ligands	COA, PO4, SO4

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3UFX \| pdb_00003ufx	Download File View File

Thermus aquaticus succinyl-CoA synthetase in complex with GDP-Mn2+

Fraser, M.E.

(2012) Acta Crystallogr D Biol Crystallogr 68: 751-762

Released	2012-06-27
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Thermus aquaticus
Macromolecule	Succinyl-CoA synthetase beta subunit (protein) succinyl-CoA synthetase alpha subunit (protein)
Unique Ligands	GDP, MN

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6WTJ \| pdb_00006wtj	Download File View File

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2020) Nat Commun 11: 4282-4282

Released	2020-05-20
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	K36

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6WTK \| pdb_00006wtk	Download File View File

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2020) Nat Commun 11: 4282-4282

Released	2020-05-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	UED

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6WTM \| pdb_00006wtm	Download File View File

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2020) Nat Commun 11: 4282-4282

Released	2020-05-20
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)

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7LCO \| pdb_00007lco	Download File View File

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

Khan, M.B., Lu, J., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2021) Eur J Med Chem 222: 113584-113584

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XTJ

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7LCR \| pdb_00007lcr	Download File View File

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2021) Eur J Med Chem 222: 113584-113584

Released	2022-12-07
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XTM

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7LCS \| pdb_00007lcs	Download File View File

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2021) Eur J Med Chem 222: 113584-113584

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XTP

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7LCT \| pdb_00007lct	Download File View File

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

Khan, M.B., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2021) Eur J Med Chem 222: 113584-113584

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XU4

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7LDL \| pdb_00007ldl	Download File View File

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

Khan, M.B., Lu, J., Arutyunova, E., Young, H.S., Lemieux, M.J.

(2021) Eur J Med Chem 222: 113584-113584

Released	2021-07-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XV4

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7MBI \| pdb_00007mbi	Download File View File

Structure of SARS-CoV2 3CL protease covalently bound to peptidomimetic inhibitor

Khan, M.B., Lu, J., Young, H.S., Lemieux, M.J.

(2022) J Med Chem 65: 2905-2925

Released	2021-07-21
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	FN7, YWJ

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7R7H \| pdb_00007r7h	Download File View File

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors

Khan, M.B., Lu, J., Young, H.S., Lemieux, M.J.

(2021) RSC Med Chem 12: 1722-1730

Released	2021-09-01
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	4IT

1 to 15 of 15 Structures

Page 1 of 1

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1CQI | pdb_00001cqi

Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase

1CQJ | pdb_00001cqj

CRYSTAL STRUCTURE OF DEPHOSPHORYLATED E. COLI SUCCINYL-COA SYNTHETASE

1JKJ | pdb_00001jkj

E. coli SCS

1JLL | pdb_00001jll

Crystal Structure Analysis of the E197betaA Mutant of E. coli SCS

3UFX | pdb_00003ufx

Thermus aquaticus succinyl-CoA synthetase in complex with GDP-Mn2+

6WTJ | pdb_00006wtj

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

6WTK | pdb_00006wtk

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

6WTM | pdb_00006wtm

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

7LCO | pdb_00007lco

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

7LCR | pdb_00007lcr

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

7LCS | pdb_00007lcs

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

7LCT | pdb_00007lct

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

7LDL | pdb_00007ldl

Improved Feline Drugs as SARS-CoV-2 Mpro Inhibitors: Structure-Activity Studies & Micellar Solubilization for Enhanced Bioavailability

7MBI | pdb_00007mbi

Structure of SARS-CoV2 3CL protease covalently bound to peptidomimetic inhibitor

7R7H | pdb_00007r7h

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

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Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1CQI | pdb_00001cqi

1CQJ | pdb_00001cqj

1JKJ | pdb_00001jkj

1JLL | pdb_00001jll

3UFX | pdb_00003ufx

6WTJ | pdb_00006wtj

6WTK | pdb_00006wtk

6WTM | pdb_00006wtm

7LCO | pdb_00007lco

7LCR | pdb_00007lcr

7LCS | pdb_00007lcs

7LCT | pdb_00007lct

7LDL | pdb_00007ldl

7MBI | pdb_00007mbi

7R7H | pdb_00007r7h