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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Clark, K.R."

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

	Homo sapiens (19)
	Mycobacterium tuberculosis (2)
	Aliarcobacter butzleri RM4018 (1)
	Staphylococcus aureus (1)

Taxonomy

	Eukaryota (19)
	Bacteria (4)

Experimental Method

X-RAY DIFFRACTION (22)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (3)
	2.0 - 2.5 (8)
	2.5 - 3.0 (6)
	3.5 - 4.0 (1)

Release Date

	2005 - 2009 (1)
	2015 - 2019 (8)
	2020 - 2024 (13)

Enzyme Classification Name

	Transferases (15)
	Hydrolases (12)
	Oxidoreductases (3)

Membrane Protein Annotation

	MemProtMD (1)
	OPM (1)
	PDBTM (1)
	mpstruc (1)

Symmetry Type

	Asymmetric (12)
	Cyclic (12)

SCOP Classification

	All alpha proteins (4)
	All beta proteins (1)
	Alpha and beta proteins (a+b) (2)
	Artifacts (1)

AllSelected

1 to 22 of 22 Structures

Page 1 of 1

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3JUY \| pdb_00003juy	Download File View File

Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody

Clark, K.R., Walsh, S.T.

(2009) Protein Sci 18: 2429-2441

Released	2009-12-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	3B3 single chain variant HIV-1 antibody (protein)

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5CEI \| pdb_00005cei	Download File View File

Crystal structure of CDK8:Cyclin C complex with compound 22

Kiefer, J.R., Schneider, E.V., Maskos, K., Koehler, M.F.T.

(2016) ACS Med Chem Lett 7: 223-228

Released	2016-02-10
Method	X-RAY DIFFRACTION 2.24 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	50R, EDO, FMT

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5EK0 \| pdb_00005ek0	Download File View File

Human Nav1.7-VSD4-NavAb in complex with GX-936.

Ahuja, S., Mukund, S., Starovasnik, M.A., Koth, C.M., Payandeh, J.

(2015) Science 350: aac5464-aac5464

Released	2015-12-23
Method	X-RAY DIFFRACTION 3.53 Å
Organisms	Aliarcobacter butzleri RM4018 Homo sapiens
Macromolecule	Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha (protein)
Unique Ligands	5P2, PX4

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5UQV \| pdb_00005uqv	Download File View File

USP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)

Murray, J.M., Rouge, L.

(2017) Nature 550: 534-538

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	8JM

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5UQX \| pdb_00005uqx	Download File View File

USP7 in complex with GNE6776 (6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide)

Murray, J.M., Rouge, L.

(2017) Nature 550: 534-538

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	8JP

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5W0E \| pdb_00005w0e	Download File View File

CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)

Murray, J.M.

(2017) J Med Chem 60: 10151-10171

Released	2018-02-21
Method	X-RAY DIFFRACTION 1.41 Å
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein)
Unique Ligands	9U4

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6AXQ \| pdb_00006axq	Download File View File

CREBBP bromodomain in complex with Cpd6 (methyl 1H-indole-3-carboxylate)

Murray, J.M., Jayaram, H.

(2017) J Med Chem 60: 10151-10171

Released	2018-02-21
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein)
Unique Ligands	C2Y, DMS

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6AY3 \| pdb_00006ay3	Download File View File

CREBBP bromodomain in complex with Cpd16 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1H-indole-3-carboxamide)

Murray, J.M.

(2017) J Med Chem 60: 10151-10171

Released	2018-02-21
Method	X-RAY DIFFRACTION 1.391 Å
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein)
Unique Ligands	C3J, EDO, NA

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6AY5 \| pdb_00006ay5	Download File View File

CREBBP bromodomain in complex with Cpd17 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3-methylbenzo[d]thiazol-2(3H)-one)

Murray, J.M.

(2017) J Med Chem 60: 10151-10171

Released	2018-02-21
Method	X-RAY DIFFRACTION 1.44 Å
Organisms	Homo sapiens
Macromolecule	CREB-binding protein (protein)
Unique Ligands	C3V, DMS, GOL, SO4

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6W39 \| pdb_00006w39	Download File View File

Structure of unphosphorylated IRE1 in complex with G-1749

Ferri, E., Wang, W., Joachim, R., Mortara, K.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 1.736 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJG

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6W3A \| pdb_00006w3a	Download File View File

Structure of unphosphorylated IRE1 in complex with G-7658

Ferri, E., Wang, W., Joachim, R., Mortara, K.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.606 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJM

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6W3B \| pdb_00006w3b	Download File View File

Structure of apo unphosphorylated IRE1

Wallweber, H., Mortara, K., Ferri, E., Rudolph, J., Wang, W.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)

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6W3C \| pdb_00006w3c	Download File View File

Structure of phosphorylated apo IRE1

Wallweber, H., Mortara, K., Ferri, E., Wang, W., Rudolph, J.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)

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6W3E \| pdb_00006w3e	Download File View File

Structure of phosphorylated IRE1 in complex with G-0701

Ferri, E., Wang, W., Joachim, R., Mortara, K.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.737 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJV

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6W3K \| pdb_00006w3k	Download File View File

Structure of unphosphorylated human IRE1 bound to G-9807

Lammens, A., Wang, W., Ferri, E., Rudolph, J.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJS

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6XDB \| pdb_00006xdb	Download File View File

Crystal structure of IRE1a in complex with G-6904

Wallweber, H.A., Weiru, W.

(2020) ACS Med Chem Lett 11: 2389-2396

Released	2021-04-21
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	EPE, N8S

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6XDD \| pdb_00006xdd	Download File View File

Crystal structure of IRE1 in complex with G-3053

Ackerly-Wallweber, H., Wang, W.

(2020) ACS Med Chem Lett 11: 2389-2396

Released	2021-04-21
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	N97

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6XDF \| pdb_00006xdf	Download File View File

Crystal structure of IRE1a in complex with G-4100

Steinbacher, S., Wang, W.

(2020) ACS Med Chem Lett 11: 2389-2396

Released	2021-04-21
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	N94, NA

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8UVL \| pdb_00008uvl	Download File View File

Crystal structure of selective IRE1a inhibitor 29 at the enzyme active site

Kiefer, J.R., Wallweber, H.A., Braun, M.-G., Wei, W., Jiang, F., Wang, W., Rudolph, J., Ashkenazi, A.

(2024) J Med Chem 67: 8708-8729

Released	2024-05-29
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	EDO, XOE

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9AV0 \| pdb_00009av0	Download File View File

Crystal structure of S. aureus GuaB dCBS with inhibitor GNE2011

Harris, S.F., Wu, P.

(2024) mBio 15: e0089724-e0089724

Released	2024-11-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Staphylococcus aureus
Macromolecule	Inosine-5'-monophosphate dehydrogenase (protein)
Unique Ligands	A1AG0, IMP

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9DC8 \| pdb_00009dc8	Download File View File

Mtb GuaB dCBS in complex with inhibitor G1

Harris, S.F., Wu, P.

(2025) Bioorg Med Chem Lett 117: 130026-130026

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Inosine-5'-monophosphate dehydrogenase (protein)
Unique Ligands	IMP, SO4, VOA

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9DC9 \| pdb_00009dc9	Download File View File

Mtb GuaB dCBS in complex with inhibitor compound 5

Harris, S.F., Wu, P.

(2025) Bioorg Med Chem Lett 117: 130026-130026

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Inosine-5'-monophosphate dehydrogenase (protein)
Unique Ligands	A1A3K, IMP

1 to 22 of 22 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

3JUY | pdb_00003juy

5CEI | pdb_00005cei

5EK0 | pdb_00005ek0

5UQV | pdb_00005uqv

5UQX | pdb_00005uqx

5W0E | pdb_00005w0e

6AXQ | pdb_00006axq

6AY3 | pdb_00006ay3

6AY5 | pdb_00006ay5

6W39 | pdb_00006w39

6W3A | pdb_00006w3a

6W3B | pdb_00006w3b

6W3C | pdb_00006w3c

6W3E | pdb_00006w3e

6W3K | pdb_00006w3k

6XDB | pdb_00006xdb

6XDD | pdb_00006xdd

6XDF | pdb_00006xdf

8UVL | pdb_00008uvl

9AV0 | pdb_00009av0

9DC8 | pdb_00009dc8

9DC9 | pdb_00009dc9