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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Brinkmann-Chen, S."

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Search Summary

This query matches 20 Structures.

Refinements

Structure Determination Methodology

experimental (20)

Scientific Name of Source Organism

	Pyrococcus furiosus DSM 3638 (8)
	Ignisphaera aggregans DSM 17230 (3)
	Slackia exigua ATCC 700122 (2)
	Streptomyces scabiei 87.22 (2)
	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 (1)
	Azotobacter vinelandii DJ (1)
	Candidatus Methanophaga sp. (1)
	Escherichia coli (1)
	Priestia megaterium (1)

Taxonomy

	Archaea (12)
	Bacteria (8)

Experimental Method

X-RAY DIFFRACTION (20)

Polymer Entity Type

Protein (20)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.0 - 1.5 (5)
	1.5 - 2.0 (9)
	2.0 - 2.5 (2)
	2.5 - 3.0 (3)

Release Date

	2010 - 2014 (5)
	2015 - 2019 (15)

Enzyme Classification Name

	Oxidoreductases (10)
	Lyases (8)

Symmetry Type

	Cyclic (15)
	Asymmetric (5)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (15)
	All alpha proteins (8)
	Artifacts (3)
	Multi-domain proteins (alpha and beta) (1)

AllSelected

1 to 20 of 20 Structures

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4KQW \| pdb_00004kqw	Download File View File

The structure of the Slackia exigua KARI in complex with NADP

Brinkmann-Chen, S., Flock, T., Cahn, J.K.B., Snow, C.D., Brustad, E.M., Mcintosh, J.A., Meinhold, P., Zhang, L., Arnold, F.H.

(2013) Proc Natl Acad Sci U S A 110: 10946-10951

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.39 Å
Organisms	Slackia exigua ATCC 700122
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	MG, NAP, TLA

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4KQX \| pdb_00004kqx	Download File View File

Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor

Brinkmann-Chen, S., Flock, T., Cahn, J.K.B., Snow, C.D., Brustad, E.M., Mcintosh, J.A., Meinhold, P., Zhang, L., Arnold, F.H.

(2013) Proc Natl Acad Sci U S A 110: 10946-10951

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Slackia exigua ATCC 700122
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	HIO, HIS, MG, NAD

Explore in 3D

4TPN \| pdb_00004tpn	Download File View File

High-resolution structure of TxtE in the absence of substrate

Cahn, J.K.B., Dodani, S.C., Brinkmann-Chen, S., Heinsich, T., McIntosh, J.A., Arnold, F.H.

(2014) Chembiochem 15: 2259-2267

Released	2014-09-10
Method	X-RAY DIFFRACTION 1.18 Å
Organisms	Streptomyces scabiei 87.22
Macromolecule	Putative P450-like protein (protein)
Unique Ligands	GOL, HEM, LI, SO4

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4TPO \| pdb_00004tpo	Download File View File

High-resolution structure of TxtE with bound tryptophan substrate

Cahn, J.K.B., Dodani, S.C., Brinkmann-Chen, S., Heinsich, T., McIntosh, J.A., Arnold, F.H.

(2014) Chembiochem 15: 2259-2267

Released	2014-09-10
Method	X-RAY DIFFRACTION 1.225 Å
Organisms	Streptomyces scabiei 87.22
Macromolecule	Putative P450-like protein (protein)
Unique Ligands	GOL, HEM, SO4, TRP

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4TSK \| pdb_00004tsk	Download File View File

Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2014) Metab Eng 26C: 17-22

Released	2014-07-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	MG, NDP, TLA

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4XDY \| pdb_00004xdy	Download File View File

Structure of NADH-preferring ketol-acid reductoisomerase from an uncultured archean

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.535 Å
Organisms	Candidatus Methanophaga sp.
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	GOL, HIO, MG, NAI

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4XDZ \| pdb_00004xdz	Download File View File

Holo structure of ketol-acid reductoisomerase from Ignisphaera aggregans

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	40E, EPE, GOL, MG, NDP

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4XEH \| pdb_00004xeh	Download File View File

Apo structure of KARI from Ignisphaera aggregans

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.391 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)

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4XIY \| pdb_00004xiy	Download File View File

Crystal structure of ketol-acid reductoisomerase from Azotobacter

Spatzal, T., Cahn, J.K.B., Wiig, J.A., Einsle, O., Hu, Y., Ribbe, M.W., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Azotobacter vinelandii DJ
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	FE, MG, PEG, PG4, PGE

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5BR4 \| pdb_00005br4	Download File View File

E. coli lactaldehyde reductase (FucO) M185C mutant

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2016) Protein Eng Des Sel 29: 31-38

Released	2015-12-23
Method	X-RAY DIFFRACTION 0.91 Å
Organisms	Escherichia coli
Macromolecule	Lactaldehyde reductase (protein)
Unique Ligands	CL, GOL, NAD, ZN

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5DVZ \| pdb_00005dvz	Download File View File

Holo TrpB from Pyrococcus furiosus

Buller, A.R., Arnold, F.H.

(2015) Proc Natl Acad Sci U S A 112: 14599-14604

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	NA, PO4

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5DW0 \| pdb_00005dw0	Download File View File

TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine

Buller, A.R., Arnold, F.H.

(2015) Proc Natl Acad Sci U S A 112: 14599-14604

Released	2015-11-11
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	NA, PLS

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5DW3 \| pdb_00005dw3	Download File View File

Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site

Buller, A.R., Arnold, F.H.

(2015) Proc Natl Acad Sci U S A 112: 14599-14604

Released	2015-11-11
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	NA, PO4, TRP

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5E0K \| pdb_00005e0k	Download File View File

X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A

Buller, A.R., Murciano-Calles, J., Arnold, F.H.

(2015) Proc Natl Acad Sci U S A 112: 14599-14604

Released	2015-11-11
Method	X-RAY DIFFRACTION 2.76 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain 1 (protein)
Unique Ligands	PO4

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5E4R \| pdb_00005e4r	Download File View File

Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD

Cahn, J.K.B., Brinkmann-Chen, S., Buller, A.R., Arnold, F.H.

(2016) Protein Sci 25: 1241-1248

Released	2015-12-23
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	40E, EDO, GOL, MG, NAP

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5IXJ \| pdb_00005ixj	Download File View File

Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in the active site

Buller, A.R., Herger, M., Arnold, F.H.

(2016) J Am Chem Soc 138: 8388-8391

Released	2016-08-17
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	NA, THR

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5UCW \| pdb_00005ucw	Download File View File

Cytochrome P411 P-4 A82L A78V F263L amination catalyst

Zhang, R.K., Buller, A.R., Arnold, F.H.

(2017) Nat Chem 9: 629-634

Released	2017-05-17
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Priestia megaterium
Macromolecule	NADPH-cytochrome P450 reductase 102A1V3 (protein)
Unique Ligands	HEM

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6CUT \| pdb_00006cut	Download File View File

Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine

Boville, C.E., Scheele, R.A., Buller, A.R., Arnold, F.H.

(2018) Angew Chem Int Ed Engl 57: 14764-14768

Released	2018-09-26
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	FEJ, NA

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6CUV \| pdb_00006cuv	Download File View File

Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6

Scheele, R.A., Buller, A.R., Boville, C.E., Arnold, F.H.

(2018) Angew Chem Int Ed Engl 57: 14764-14768

Released	2018-09-26
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	NA, PO4

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6CUZ \| pdb_00006cuz	Download File View File

Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate

Scheele, R.A., Buller, A.R., Boville, C.E., Arnold, F.H.

(2018) Angew Chem Int Ed Engl 57: 14764-14768

Released	2018-09-26
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Pyrococcus furiosus DSM 3638
Macromolecule	Tryptophan synthase beta chain 1 (protein)
Unique Ligands	FEV, NA, PO4

1 to 20 of 20 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4KQW | pdb_00004kqw

The structure of the Slackia exigua KARI in complex with NADP

4KQX | pdb_00004kqx

Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor

4TPN | pdb_00004tpn

High-resolution structure of TxtE in the absence of substrate

4TPO | pdb_00004tpo

High-resolution structure of TxtE with bound tryptophan substrate

4TSK | pdb_00004tsk

Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius

4XDY | pdb_00004xdy

Structure of NADH-preferring ketol-acid reductoisomerase from an uncultured archean

4XDZ | pdb_00004xdz

Holo structure of ketol-acid reductoisomerase from Ignisphaera aggregans

4XEH | pdb_00004xeh

Apo structure of KARI from Ignisphaera aggregans

4XIY | pdb_00004xiy

Crystal structure of ketol-acid reductoisomerase from Azotobacter

5BR4 | pdb_00005br4

E. coli lactaldehyde reductase (FucO) M185C mutant

5DVZ | pdb_00005dvz

Holo TrpB from Pyrococcus furiosus

5DW0 | pdb_00005dw0

TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine

5DW3 | pdb_00005dw3

Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site

5E0K | pdb_00005e0k

X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A

5E4R | pdb_00005e4r

Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD

5IXJ | pdb_00005ixj

Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in the active site

5UCW | pdb_00005ucw

Cytochrome P411 P-4 A82L A78V F263L amination catalyst

6CUT | pdb_00006cut

Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine

6CUV | pdb_00006cuv

Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6

6CUZ | pdb_00006cuz

Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4KQW | pdb_00004kqw

4KQX | pdb_00004kqx

4TPN | pdb_00004tpn

4TPO | pdb_00004tpo

4TSK | pdb_00004tsk

4XDY | pdb_00004xdy

4XDZ | pdb_00004xdz

4XEH | pdb_00004xeh

4XIY | pdb_00004xiy

5BR4 | pdb_00005br4

5DVZ | pdb_00005dvz

5DW0 | pdb_00005dw0

5DW3 | pdb_00005dw3

5E0K | pdb_00005e0k

5E4R | pdb_00005e4r

5IXJ | pdb_00005ixj

5UCW | pdb_00005ucw

6CUT | pdb_00006cut

6CUV | pdb_00006cuv

6CUZ | pdb_00006cuz