RCSB PDB: Search

4AI8 \| pdb_00004ai8	Download File View File

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE

King, O.N.F., Chowdhury, R., Rose, N.R., McDonough, M.A., Clifton, I.J., Schofield, C.J., Kawamura, A.

(2012) J Med Chem 55: 6639-6643

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (protein)
Unique Ligands	DZA, GOL, SO4, ZN

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4AI9 \| pdb_00004ai9	Download File View File

JMJD2A Complexed with Daminozide

Chowdhury, R., Schofield, C.J.

(2012) J Med Chem 55: 6639-6643

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 4A (protein)
Unique Ligands	CL, DZA, GOL, NI, ZN

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4BIO \| pdb_00004bio	Download File View File

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID

Chowdhury, R., Schofield, C.J.

(2013) Chem Sci 4: 3110-3117

Released	2013-04-24
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (protein)
Unique Ligands	8XQ, FE, GOL, SO4

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4BIS \| pdb_00004bis	Download File View File

JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

Chowdhury, R., Thinnes, C., Schofield, C.J.

(2013) Chem Sci 4: 3110-3117

Released	2014-02-05
Method	X-RAY DIFFRACTION 2.493 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 4A (protein)
Unique Ligands	8HQ, CL, GOL, NI, ZN

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4BW5 \| pdb_00004bw5	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)

Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.

(2015) Science 347: 1256

Released	2013-07-31
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 (protein)
Unique Ligands	CD, K, PC1

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4C8B \| pdb_00004c8b	Download File View File

Structure of the kinase domain of human RIPK2 in complex with ponatinib

Canning, P., Krojer, T., Bradley, A., Mahajan, P., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2015) Chem Biol 22: 1174-1184

Released	2013-10-16
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (protein)
Unique Ligands	0LI, EDO

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4E96 \| pdb_00004e96	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1

Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Fish, P., Bunnage, M., Owen, D., Knapp, S., Cook, A., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-04-18
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	0NS, DMS, EDO, NA

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4GPJ \| pdb_00004gpj	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a isoxazolylbenzimidazole ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Heightman, T.D., Brennan, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)

(2013) Medchemcomm 4: 140-144

Released	2012-10-17
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	0Q1, EDO, NA

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4HBV \| pdb_00004hbv	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-10-31
Method	X-RAY DIFFRACTION 1.63 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	15E, EDO

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4HBW \| pdb_00004hbw	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-10-31
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	14Z, EDO, K

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4HBX \| pdb_00004hbx	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-10-31
Method	X-RAY DIFFRACTION 1.62 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	14X

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4HBY \| pdb_00004hby	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-10-31
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	13F, EDO

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4J0R \| pdb_00004j0r	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Hewings, D.S., von Delft, F., Conway, S.J., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)

(2013) J Med Chem 56: 3217-3227

Released	2013-02-13
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	1H2, EDO, IOD

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4J0S \| pdb_00004j0s	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Hewings, D.S., von Delft, F., Conway, S.J., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)

(2013) J Med Chem 56: 3217-3227

Released	2013-02-13
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	1H3, EDO

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4JHT \| pdb_00004jht	Download File View File

Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1)

Aik, W.S., McDonough, M.A., Schofield, C.J.

(2013) Chem Sci 4: 3110-3117

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.18 Å
Organisms	Escherichia coli K-12
Macromolecule	Alpha-ketoglutarate-dependent dioxygenase AlkB (protein)
Unique Ligands	8XQ, ACT, DMS, MN

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4MR3 \| pdb_00004mr3	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)

Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2013) Proc Natl Acad Sci U S A 110: 19754-19759

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.68 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	1K0, EDO

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4MR4 \| pdb_00004mr4	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-208)

Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2013) Proc Natl Acad Sci U S A 110: 19754-19759

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.66 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	1K0, EDO

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4MR5 \| pdb_00004mr5	Download File View File

Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH)

Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2013) Proc Natl Acad Sci U S A 110: 19754-19759

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.63 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 2 (protein)
Unique Ligands	1K0, DMS, EDO

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4MR6 \| pdb_00004mr6	Download File View File

Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208)

Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2013) Proc Natl Acad Sci U S A 110: 19754-19759

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 2 (protein)
Unique Ligands	1K0, DMS, EDO

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4NXJ \| pdb_00004nxj	Download File View File

Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum

Wernimont, A.K., Loppnau, P., Knapp, S., Fonseca, M., Brennan, P.E., Dong, A., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., Structural Genomics Consortium (SGC)

To be published

Released	2014-03-19
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Bromodomain protein (protein)

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4PY6 \| pdb_00004py6	Download File View File

Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum

Fonseca, M., Tallant, C., Hutchinson, A., Savitsky, P., Krojer, T., Filippakopoulos, P., Loppnau, P., Brennan, P.E., von Delft, F., Dong, A., Josling, G.A., Duffy, M.F., Arrowsmith, C.H., Bountra, C., Hui, R., Knapp, S., Wernimont, A.K., Structural Genomics Consortium (SGC)

To be published

Released	2014-04-30
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Bromodomain protein, putative (protein)
Unique Ligands	EDO, R78

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4UF0 \| pdb_00004uf0	Download File View File

Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid.

Srikannathasan, V., Johansson, C., Gileadi, C., Tobias, K., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.

(2016) Nat Chem Biol 12: 539

Released	2015-01-14
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	HISTONE DEMETHYLASE UTY (protein)
Unique Ligands	EDO, FE2, MMK, ZN

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4URA \| pdb_00004ura	Download File View File

Crystal structure of human JMJD2A in complex with compound 14a

Krojer, T., England, K.S., Vollmar, M., Crawley, L., Williams, E., Riesebos, E., Szykowska, A., Burgess-Brown, N., Oppermann, U., Brennan, P.E., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2014) Medchemcomm 5: 1879-1886

Released	2015-06-17
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 4A (protein)
Unique Ligands	EDO, LEL, NI, SO4, ZN

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4XDJ \| pdb_00004xdj	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)

Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)

(2015) Science 347: 1256-1259

Released	2015-03-18
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Homo sapiens
Macromolecule	POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 (protein)
Unique Ligands	K, PC1, TRD

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4XDK \| pdb_00004xdk	Download File View File

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine

Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)

(2015) Science 347: 1256-1259

Released	2015-03-18
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Homo sapiens
Macromolecule	Potassium channel subfamily K member 10 (protein)
Unique Ligands	405, 408, K, PC1

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

4AI8 | pdb_00004ai8

4AI9 | pdb_00004ai9

4BIO | pdb_00004bio

4BIS | pdb_00004bis

4BW5 | pdb_00004bw5

4C8B | pdb_00004c8b

4E96 | pdb_00004e96

4GPJ | pdb_00004gpj

4HBV | pdb_00004hbv

4HBW | pdb_00004hbw

4HBX | pdb_00004hbx

4HBY | pdb_00004hby

4J0R | pdb_00004j0r

4J0S | pdb_00004j0s

4JHT | pdb_00004jht

4MR3 | pdb_00004mr3

4MR4 | pdb_00004mr4

4MR5 | pdb_00004mr5

4MR6 | pdb_00004mr6

4NXJ | pdb_00004nxj

4PY6 | pdb_00004py6

4UF0 | pdb_00004uf0

4URA | pdb_00004ura

4XDJ | pdb_00004xdj

4XDK | pdb_00004xdk