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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Alvarez-Bernad, B."

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Bos taurus (15)
	Gallus gallus (14)
	Rattus norvegicus (14)
	synthetic construct (1)

Taxonomy

	Eukaryota (15)
	other sequences (1)

Experimental Method

X-RAY DIFFRACTION (15)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (10)
	2.5 - 3.0 (3)

Release Date

2020 - 2024 (15)

Enzyme Classification Name

	Hydrolases (15)
	Ligases (4)

Symmetry Type

Asymmetric (15)

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1 to 15 of 15 Structures

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5SB8 \| pdb_00005sb8	Download File View File

Tubulin-maytansinoid-3-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5IS, ACP, CA, GDP, GTP, IMD, MES, MG

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5SB9 \| pdb_00005sb9	Download File View File

Tubulin-maytansinoid-4a-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5IX, ACP, CA, GDP, GTP, IMD, MES, MG

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5SBA \| pdb_00005sba	Download File View File

Tubulin-maytansinoid-4b-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5IJ, ACP, CA, GDP, GOL, GTP, IMD, MES, MG

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5SBB \| pdb_00005sbb	Download File View File

Tubulin-maytansinoid-4c-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5JH, ACP, CA, GDP, GOL, GTP, IMD, MES, MG

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5SBC \| pdb_00005sbc	Download File View File

Tubulin-maytansinoid-5a-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.32 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5JS, ACP, CA, GDP, GOL, GTP, IMD, MES, MG

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5SBD \| pdb_00005sbd	Download File View File

Tubulin-maytansinoid-5b-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5KI, ACP, CA, GDP, GOL, GTP, IMD, MES, MG

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5SBE \| pdb_00005sbe	Download File View File

Tubulin-maytansinoid-5c-complex

Marzullo, P., Boiarska, Z., Perez-Pena, H., Abel, A.-C., Alvarez-Bernad, B., Lucena-Agell, D., Vasile, F., Sironi, M., Steinmetz, M.O., Prota, A.E., Diaz, J.F., Pieraccini, S., Passarella, D.

(2022) Chemistry 28: e202103520-e202103520

Released	2021-12-08
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	5L5, ACP, CA, GDP, GTP, MES, MG

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7ODN \| pdb_00007odn	Download File View File

Crystal structure of TD1-mebendazole complex

Oliva, M.A., Bonato, F., Diaz, J.F.

(2022) Int J Mol Sci 23:

Released	2022-04-06
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Bos taurus synthetic construct
Macromolecule	Designed Ankyrin Repeat Protein (DARPIN) D1 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-3 chain (protein)
Unique Ligands	CL, GDP, GOL, GTP, MG, SO4, V95

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7OGN \| pdb_00007ogn	Download File View File

Crystal structure of T2R-TTL -mebendazole complex

Oliva, M.A., Bonato, F., Diaz, J.F.

(2022) Int J Mol Sci 23:

Released	2022-04-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	ACP, CA, CL, GDP, GOL, GTP, IMD, MES, MG, V95

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7ZX2 \| pdb_00007zx2	Download File View File

Tubulin-Pelophen B complex

Estevez-Gallego, J., Diaz, J.F., Van der Eycken, J., Oliva, M.A.

(2023) Structure 31: 88-99.e5

Released	2022-11-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ACP, CA, CL, DMS, GDP, GOL, GTP, K9I, MES, MG

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7ZYW \| pdb_00007zyw	Download File View File

Crystal structure of T2R-TTL-PM534 complex

Oliva, M.A., Diaz, J.F., Cuevas, C.

(2024) J Med Chem 67: 2619-2630

Released	2023-11-29
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ACP, CA, CL, DMS, GDP, GOL, GTP, KG0, MES, MG

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8A0L \| pdb_00008a0l	Download File View File

Tubulin-CW1-complex

Prota, A.E., Diaz, J.F., Steinmetz, M.O., Oliva, M.A.

(2023) Structure 31: 88-99.e5

Released	2022-12-14
Method	X-RAY DIFFRACTION 1.9981 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, KLC, MES, MG

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8B7A \| pdb_00008b7a	Download File View File

Tubulin - maytansinoid - 4 complex

Boiarska, Z., Perez-Pena, H., Abel, A.-C., Marzullo, P., Alvarez-Bernad, B., Bonato, F., Santini, B., Horvath, D., Lucena-Agell, D., Vasile, F., Sironi, M., Diaz, F.J., Steinmetz, M.O., Prota, A.E., Piaraccini, S., Passarella, D.

(2023) Chemistry 29: e202203431-e202203431

Released	2023-08-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin tyrosine ligase (protein)
Unique Ligands	ACP, CA, GDP, GTP, IMD, MES, MG, Q0F

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8B7B \| pdb_00008b7b	Download File View File

Tubulin - maytansinoid - 6 complex

Boiarska, Z., Perez-Pena, H., Abel, A.-C., Marzullo, P., Alvarez-Bernad, B., Bonato, F., Santini, B., Horvath, D., Lucena-Agell, D., Vasile, F., Sironi, M., Diaz, J.F., Steinmetz, M.O., Prota, A.E., Pieraccini, S., Passarella, D.

(2023) Chemistry 29: e202203431-e202203431

Released	2023-08-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin tyrosine ligase (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, MES, MG, PX0

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8B7C \| pdb_00008b7c	Download File View File

Tubulin-maytansinoid-12 complex

(2023) Chemistry 29: e202203431-e202203431

Released	2023-08-23
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin tyrosine ligase (protein)
Unique Ligands	ACP, CA, GDP, GTP, IMD, MES, MG, PWC

1 to 15 of 15 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

5SB8 | pdb_00005sb8

Tubulin-maytansinoid-3-complex

5SB9 | pdb_00005sb9

Tubulin-maytansinoid-4a-complex

5SBA | pdb_00005sba

Tubulin-maytansinoid-4b-complex

5SBB | pdb_00005sbb

Tubulin-maytansinoid-4c-complex

5SBC | pdb_00005sbc

Tubulin-maytansinoid-5a-complex

5SBD | pdb_00005sbd

Tubulin-maytansinoid-5b-complex

5SBE | pdb_00005sbe

Tubulin-maytansinoid-5c-complex

7ODN | pdb_00007odn

Crystal structure of TD1-mebendazole complex

7OGN | pdb_00007ogn

Crystal structure of T2R-TTL -mebendazole complex

7ZX2 | pdb_00007zx2

Tubulin-Pelophen B complex

7ZYW | pdb_00007zyw

Crystal structure of T2R-TTL-PM534 complex

8A0L | pdb_00008a0l

Tubulin-CW1-complex

8B7A | pdb_00008b7a

Tubulin - maytansinoid - 4 complex

8B7B | pdb_00008b7b

Tubulin - maytansinoid - 6 complex

8B7C | pdb_00008b7c

Tubulin-maytansinoid-12 complex

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Structure Determination Methodology

Scientific Name of Source Organism

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Release Date

Enzyme Classification Name

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5SB8 | pdb_00005sb8

5SB9 | pdb_00005sb9

5SBA | pdb_00005sba

5SBB | pdb_00005sbb

5SBC | pdb_00005sbc

5SBD | pdb_00005sbd

5SBE | pdb_00005sbe

7ODN | pdb_00007odn

7OGN | pdb_00007ogn

7ZX2 | pdb_00007zx2

7ZYW | pdb_00007zyw

8A0L | pdb_00008a0l

8B7A | pdb_00008b7a

8B7B | pdb_00008b7b

8B7C | pdb_00008b7c