QUERY: Structure Author = "Feng, J."
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Search Summary This query matches 78 Structures.
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1 to 25 of 78 Structures
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2ONC | pdb_00002onc

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Crystal structure of human DPP-4

Feng, J., Zhang, Z., Wallace, M.B., Stafford, J.A., Kaldor, S.W., Kassel, D.B., Navre, M., Shi, L., Skene, R.J., Asakawa, T., Takeuchi, K., Xu, R., Webb, D.R., Gwaltney, S.L.

(2007) J Med Chem 50: 2297-2300

Released2008-03-04
Method
X-RAY DIFFRACTION 2.55 Å
Organisms
Macromolecule
Unique LigandsNAG, SY1
Unique branched monosaccharidesNAG
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3G0B | pdb_00003g0b

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Crystal structure of dipeptidyl peptidase IV in complex with TAK-322

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released2010-02-16
Method
X-RAY DIFFRACTION 2.25 Å
Organisms
Macromolecule
Unique LigandsNAG, T22
Unique branched monosaccharidesNAG
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3G0C | pdb_00003g0c

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Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released2010-02-16
Method
X-RAY DIFFRACTION 2.69 Å
Organisms
Macromolecule
Unique LigandsNAG, RUF
Unique branched monosaccharidesNAG
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3G0D | pdb_00003g0d

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Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 2

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released2010-02-16
Method
X-RAY DIFFRACTION 2.39 Å
Organisms
Macromolecule
Unique LigandsNAG, XIH
Unique branched monosaccharidesNAG
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3G0G | pdb_00003g0g

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Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinone inhibitor 3

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released2010-02-16
Method
X-RAY DIFFRACTION 2.45 Å
Organisms
Macromolecule
Unique LigandsNAG, RUM
Unique branched monosaccharidesNAG
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3Q7J | pdb_00003q7j

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Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development

Su, J., Wang, Q., Feng, J., Zhang, C., Zhu, D., We, T., Xu, W., Gu, L.

(2011) Bioorg Med Chem 19: 2991-2996

Released2011-07-27
Method
X-RAY DIFFRACTION 2.91 Å
Organisms
Macromolecule
Unique LigandsFBO, ZN
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4DCH | pdb_00004dch

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Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

Greasley, S.E., Hickey, M., Feng, J., Garcia, E.

(2012) J Biological Chem 287: 13598-13610

Released2012-02-08
Method
X-RAY DIFFRACTION 1.79 Å
Organisms
Macromolecule
Glucokinase (protein)
Unique Ligands4DC, GLC, IOD
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4I1Z | pdb_00004i1z

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Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 3 Å
Organisms
Macromolecule
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4I20 | pdb_00004i20

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Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 3.34 Å
Organisms
Macromolecule
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4I21 | pdb_00004i21

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Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 3.37 Å
Organisms
Macromolecule
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4I22 | pdb_00004i22

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Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 1.71 Å
Organisms
Macromolecule
Unique LigandsIRE, SO4
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4I23 | pdb_00004i23

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Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 2.8 Å
Organisms
Macromolecule
Unique Ligands1C9
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4I24 | pdb_00004i24

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Structure of T790M EGFR kinase domain co-crystallized with dacomitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released2013-01-16
Method
X-RAY DIFFRACTION 1.8 Å
Organisms
Macromolecule
Unique Ligands1C9
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4QS7 | pdb_00004qs7

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Arabidopsis Hexokinase 1 (AtHXK1) structure in glucose-bound form

Feng, J., Zhao, S., Liu, L.

(2015) Acta Crystallogr D Biol Crystallogr 71: 367-375

Released2015-02-11
Method
X-RAY DIFFRACTION 2.001 Å
Organisms
Macromolecule
Hexokinase-1 (protein)
Unique LigandsBGC
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4QS8 | pdb_00004qs8

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Arabidopsis Hexokinase 1 (AtHXK1) structure in ligand-free form

Feng, J., Zhao, S., Liu, L.

(2015) Acta Crystallogr D Biol Crystallogr 71: 367-375

Released2015-02-11
Method
X-RAY DIFFRACTION 1.798 Å
Organisms
Macromolecule
Hexokinase-1 (protein)
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4QS9 | pdb_00004qs9

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Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form

Feng, J., Zhao, S., Liu, L.

(2015) Acta Crystallogr D Biol Crystallogr 71: 367-375

Released2015-02-11
Method
X-RAY DIFFRACTION 2.103 Å
Organisms
Macromolecule
Hexokinase-1 (protein)
Unique LigandsBGC
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4R3Q | pdb_00004r3q

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Crystal structure of SYCE3

Lu, J., Feng, J., Zhou, W., Yang, X., Shen, Y.

(2014) Sci Rep 4: 7059-7059

Released2014-11-26
Method
X-RAY DIFFRACTION 1.901 Å
Organisms
Macromolecule
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4R8X | pdb_00004r8x

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Crystal structure of a uricase from Bacillus fastidious

Feng, J., Wang, L., Liu, H.B., Liu, L., Liao, F.

(2015) Appl Microbiol Biotechnol 99: 7973-7986

Released2015-05-27
Method
X-RAY DIFFRACTION 1.401 Å
Organisms
Macromolecule
Uricase (protein)
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4R99 | pdb_00004r99

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Crystal structure of a uricase from Bacillus fastidious

Feng, J., Wang, L., Liu, H.B., Liu, L., Liao, F.

(2015) Appl Microbiol Biotechnol 99: 7973-7986

Released2015-05-27
Method
X-RAY DIFFRACTION 1.8 Å
Organisms
Macromolecule
Uricase (protein)
Unique LigandsSO4
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5F2E | pdb_00005f2e

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Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C

Patricelli, M.P., Janes, M.R., Li, L.-S., Hansen, R., Peters, U., Kessler, L.V., Chen, Y., Kucharski, J.M., Feng, J., Ely, T., Chen, J.H., Firdaus, S.J., Babbar, A., Ren, P., Liu, Y.

(2016) Cancer Discov 6: 316-329

Released2016-01-13
Method
X-RAY DIFFRACTION 1.4 Å
Organisms
Macromolecule
GTPase KRas (protein)
Unique Ligands5UT, GDP, GLY, GOL, MG
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5IWZ | pdb_00005iwz

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Synaptonemal complex protein

Feng, J., Fu, S., Cao, X., Wu, H., Lu, J., Zeng, M., Liu, L., Yang, X., Shen, Y.

To be published

Released2017-03-29
Method
X-RAY DIFFRACTION 2.098 Å
Organisms
Macromolecule
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5UGH | pdb_00005ugh

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Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366

Kaiser, S.E., Feng, J., Stewart, A.E.

(2017) Nat Chem Biol 13: 785-792

Released2017-05-17
Method
X-RAY DIFFRACTION 2.062 Å
Organisms
Macromolecule
Unique Ligands8AJ
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5V9U | pdb_00005v9u

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Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C

Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.

(2018) Cell 172: 578-589.e17

Released2018-02-07
Method
X-RAY DIFFRACTION 1.38 Å
Organisms
Macromolecule
GTPase KRas (protein)
Unique Ligands91S, CA, GDP, GOL
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6B0V | pdb_00006b0v

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Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C

Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M.R., Li, L.-S., Ren, P., Liu, Y., Zarrinkar, P.P.

(2018) Nat Struct Mol Biol 25: 454-462

Released2018-05-16
Method
X-RAY DIFFRACTION 1.29 Å
Organisms
Macromolecule
GTPase KRas (protein)
Unique LigandsC8G, CA, GDP
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6B0Y | pdb_00006b0y

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Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C

Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M.R., Li, L.-S., Ren, P., Liu, Y., Zarrinkar, P.P.

(2018) Nat Struct Mol Biol 25: 454-462

Released2018-05-16
Method
X-RAY DIFFRACTION 1.43 Å
Organisms
Macromolecule
GTPase KRas (protein)
Unique Ligands8ZG, CA, GDP, GOL
1 to 25 of 78 Structures
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