Omega-theraphotoxin-Gr1a

UniProtKB accession: P60590

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Polymer Entities matching query 4

Go to UniProtKB: P60590

UniProtKB description: Inhibits P/Q- (Cav2.1/CACNA1A) and N-type (Cav2.2/CACNA1B) voltage-gated calcium channel by modifying voltage-dependent gating (PubMed:29483648, PubMed:9415720). It selectively and reversibly blocks the calcium channels coupled to glutamate release (PubMed:8848236). Also inhibits potassium channels (Kv2.1/KCNB1) with lower affinity (PubMed:29483648, PubMed:9671721). Has also been shown to weakly inhibit Kv11.1/KCNH2/ERG1, Kv1.2/KCNA2, Kv1.3/KCNA3, Nav1.5/SCN5A, Nav1.7/SCN9A and TRPV1 (PubMed:29483648).

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