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Member 1 of 8
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Explore in 3D: Sequence Alignments
Pertussis toxin subunit 1
UniProtKB accession: P04977
Grouped By: Matching UniProtKB accession
Group Content:
Polymer Entities matching query 8
Go to UniProtKB: P04977
UniProtKB description: S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
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