Zorya protein ZorA

UniProtKB accession:  A7ZI10

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UniProtKB description:  Component of antiviral defense system Zorya type I, composed of ZorA, ZorB, ZorC and ZorD. Expression of Zorya type I in E.coli (strain MG1655) confers 10,000-fold resistance to phage SECphi27, 100-fold resistance to lambda, and 10-fold resistance to T7. While most T7 infected Zorya-containing cells undergo abortive infection, a minority produce viable phage progeny. These eventually accumulate to a high multiplicity of infection, leading to culture collapse by 2 hours after initial infection (PubMed:29371424). ZorA and ZorB probably assemble in the cell inner membrane and exert their effect there (Probable).