8S35 | pdb_00008s35

DNA-bound Type IV-A3 CRISPR effector in complex with DinG helicase from K. pneumoniae (state I)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
L [auth M]	PF13307	Helicase C-terminal domain (Helicase_C_2)	Helicase C-terminal domain	This domain is found at the C-terminus of DEAD-box helicases.	Domain
L [auth M]	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
G	CRISPR type AFERR-associated protein Csf1	-	-	-
A, B, C, D, E, A, B, C, D, E, K [auth L]	CRISPR type AFERR-associated protein Csf2	-	-	-
F	CRISPR type AFERR-associated protein Csf3	-	-	-
H	crRNA	-	-	-
I	TS-DNA	-	-	-
J	NTS-DNA	-	-	-
L [auth M]	DEAD/DEAH box helicase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nucleic acid binding iron-sulfur cluster binding metal cluster binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity, acting on DNA nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity macromolecular conformation isomerase activity ATP-dependent activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process primary metabolic process metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
L [auth M]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
L [auth M]	IPR045028	Helicase superfamily 1/2, DinG/Rad3-like	Family
L [auth M]	IPR006555	ATP-dependent helicase, C-terminal	Domain
L [auth M]	IPR014013	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	Domain
L [auth M]	IPR011545	DEAD/DEAH box helicase domain	Domain
L [auth M]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.