Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPK beta-barrel domain-like 8042524 3001296 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043639 3000510 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPK C-terminal domain-like 8044402 3000442 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02887Pyruvate kinase, alpha/beta domain (PK_C)Pyruvate kinase, alpha/beta domainPyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].
Domain
A, B, C, D, E
PF00224Pyruvate kinase, barrel domain (PK)Pyruvate kinase, barrel domainThis is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Pyruvate kinase PKM

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR015795Pyruvate kinase, C-terminalDomain
A, B, C, D, E
IPR015813Pyruvate/Phosphoenolpyruvate kinase-like domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR011037Pyruvate kinase-like, insert domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR015806Pyruvate kinase, insert domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR036918Pyruvate kinase, C-terminal domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR001697Pyruvate kinaseFamily
A, B, C, D, E
IPR018209Pyruvate kinase, active siteActive Site
A, B, C, D, E
IPR040442Pyruvate kinase-like domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR015793Pyruvate kinase, barrelDomain