7W2E

An open-like conformation of the sigma-1 receptor from Xenopus laevis

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ERG2_Sigma1R	e7w2eA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
A	F_UNCLASSIFIED	e7w2eA2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
B	ERG2_Sigma1R	e7w2eB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
B	F_UNCLASSIFIED	e7w2eB2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
C	ERG2_Sigma1R	e7w2eC1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
C	F_UNCLASSIFIED	e7w2eC2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
E	ERG2_Sigma1R	e7w2eE1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
E	F_UNCLASSIFIED	e7w2eE2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
F	ERG2_Sigma1R	e7w2eF1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
F	F_UNCLASSIFIED	e7w2eF2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
G	ERG2_Sigma1R	e7w2eG1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
G	F_UNCLASSIFIED	e7w2eG2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
H	ERG2_Sigma1R	e7w2eH1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
H	F_UNCLASSIFIED	e7w2eH2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
I	ERG2_Sigma1R	e7w2eI1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
I	F_UNCLASSIFIED	e7w2eI2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
J	ERG2_Sigma1R	e7w2eJ1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
J	F_UNCLASSIFIED	e7w2eJ2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
K	ERG2_Sigma1R	e7w2eK1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
K	F_UNCLASSIFIED	e7w2eK2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
L	ERG2_Sigma1R	e7w2eL1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
L	F_UNCLASSIFIED	e7w2eL2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
D	ERG2_Sigma1R	e7w2eD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
D	F_UNCLASSIFIED	e7w2eD2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF04622	ERG2 and Sigma1 receptor like protein (ERG2_Sigma1R)	ERG2 and Sigma1 receptor like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Sigma non-opioid intracellular receptor 1	-	localization transport macromolecule localization lipid localization lipid transport establishment of localization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear inner membrane nuclear envelope organelle membrane nuclear outer membrane organelle outer membrane bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network outer membrane organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR006716	ERG2/sigma1 receptor-like	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	OPM				ERG2 and Sigma1 receptor family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Novel Receptors	Sigma-1 (σ₁) receptor, closed conformation