7N1O

The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SAM/Pointed domain	8039910	3000479	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	vWA-like	8041588	3000832	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SAM_PNT	e7n1oA2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_PNT	ECOD (1.6)
A	VWA	e7n1oA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain	-	Domain
A	PF02198	Sterile alpha motif (SAM)/Pointed domain (SAM_PNT)	Sterile alpha motif (SAM)/Pointed domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription factor ETV6,Isoform 4 of Anthrax toxin receptor 2	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein binding binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein binding binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process neurogenesis multicellular organism development multicellular organismal process nervous system development developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process neurogenesis multicellular organism development multicellular organismal process nervous system development system development cellular component organization sexual reproduction reproductive process multicellular organismal reproductive process cytoplasm organization cellular component organization or biogenesis female gamete generation vitellogenesis gamete generation regulation of cellular process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process mesenchymal cell apoptotic process apoptotic process cell death programmed cell death negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cytoplasm cytosol cell periphery plasma membrane membrane chromatin chromosome cell surface endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane extracellular region organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR000418	Ets domain	Domain
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR046328	ETS family	Family
A	IPR003118	Pointed domain	Domain
A	IPR008399	Anthrax toxin receptor, C-terminal	Domain
A	IPR002035	von Willebrand factor, type A	Domain
A	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A	IPR017360	Anthrax toxin receptor	Family
A	IPR008400	Anthrax toxin receptor, extracellular domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P58335	acute myeloid leukemia thrombocytopenia 5 chronic myelomonocytic leukemia fibrosarcoma thrombocytopenia congenital mesoblastic nephroma myeloproliferative disorder, chronic, with eosinophilia cancer Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hematopoietic and lymphoid system neoplasm juvenile idiopathic arthritis macrocytosis, familial leukemia, acute lymphocytic, susceptibility to, 1 malignant ependymoma acute lymphoblastic leukemia acute myeloid leukemia thrombocytopenia 5 chronic myelomonocytic leukemia fibrosarcoma thrombocytopenia congenital mesoblastic nephroma myeloproliferative disorder, chronic, with eosinophilia cancer Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hematopoietic and lymphoid system neoplasm juvenile idiopathic arthritis macrocytosis, familial leukemia, acute lymphocytic, susceptibility to, 1 malignant ependymoma acute lymphoblastic leukemia ovarian cancer Burkitt lymphoma subependymal giant cell astrocytoma substance dependence hematologic disease thyroid gland papillary carcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm colorectal cancer drug dependence substance abuse tuberculosis large cell medulloblastoma medulloblastoma osteosarcoma breast cancer pilocytic astrocytoma childhood acute lymphoblastic leukemia psoriasis glioblastoma substance-related disorder hereditary thrombocytopenia and hematologic cancer predisposition syndrome hyaline fibromatosis syndrome ankylosing spondylitis fibroma gingival hypertrophy contracture prostate cancer osteoporosis juvenile hyaline fibromatosis Lytic lesion malignant glioma myopathy adrenal cortex carcinoma astrocytic tumor ovarian cancer breast fibroadenoma pilocytic astrocytoma primitive neuroectodermal tumor ductal breast carcinoma in situ psoriasis gastric carcinoma head and neck cancer invasive ductal breast carcinoma large cell medulloblastoma lytic metastatic bone lesion malignant pancreatic neoplasm atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma pituitary cancer Sjogren syndrome juvenile dermatomyositis lung carcinoma malignant ependymoma medulloblastoma arthrogryposis osteosarcoma breast carcinoma pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis fibromatosis tuberculosis glioblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.