Annotations: 7MMN

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth A]	Fusion_gly_3	e7mmnA1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly_3	ECOD (1.6)
F [auth C]	Fusion_gly_3	e7mmnC1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly_3	ECOD (1.6)
H [auth J]	Fusion_gly_3	e7mmnJ1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly_3	ECOD (1.6)
E [auth B]	Fusion_gly_4	e7mmnB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: Fusion_gly_4	ECOD (1.6)
E [auth B]	Fusion_gly	e7mmnB1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
G [auth I]	Fusion_gly_4	e7mmnI2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: Fusion_gly_4	ECOD (1.6)
G [auth I]	Fusion_gly	e7mmnI1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
I [auth K]	Fusion_gly_4	e7mmnK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: Fusion_gly_4	ECOD (1.6)
I [auth K]	Fusion_gly	e7mmnK1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
J [auth M]	C1-set_1	e7mmnM2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
J [auth M]	V-set_12	e7mmnM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
K [auth H]	C1-set_1	e7mmnH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
K [auth H]	V-set_12	e7mmnH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
L [auth D]	C1-set_1	e7mmnD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
L [auth D]	V-set_12	e7mmnD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
A [auth L]	C1-set_4	e7mmnL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
A [auth L]	V-set	e7mmnL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
B [auth E]	C1-set_4	e7mmnE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth E]	V-set	e7mmnE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C [auth G]	C1-set_4	e7mmnG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
C [auth G]	V-set	e7mmnG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
J [auth M], K [auth H], L [auth D]	Heavy Chain	IGHV3	-	fusion glycoprotein f1,fibritin	SAbDab (2024-12-06)
A [auth L], B [auth E], C [auth G]	Light Chain	IGKV1	Kappa	fusion glycoprotein f1,fibritin	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth B], G [auth I], I [auth K]	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D [auth A], F [auth C], H [auth J]	Fusion glycoprotein F2	identical protein binding protein binding binding	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host symbiont-mediated induction of syncytium formation symbiont-mediated perturbation of host process modulation of process of another organism	cell periphery cellular anatomical structure plasma membrane membrane virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane cell periphery cellular anatomical structure plasma membrane membrane virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region
E [auth B], G [auth I], I [auth K]	Fusion glycoprotein F1,Fibritin	identical protein binding protein binding binding	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host symbiont-mediated induction of syncytium formation symbiont-mediated perturbation of host process modulation of process of another organism	cell periphery cellular anatomical structure plasma membrane membrane virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane cell periphery cellular anatomical structure plasma membrane membrane virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region
J [auth M], K [auth H], L [auth D]	AM14 Fab Heavy Chain	-	-	-
A [auth L], B [auth E], C [auth G]	AM14 Fab Light Chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth A], F [auth C], H [auth J]	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family
E [auth B], G [auth I], I [auth K]	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family

7MMN

Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

SAbDab Antibody Annotation SAbDab Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

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7MMN

Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

SAbDab Antibody Annotation SAbDab Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage