Annotations: 7K7B

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7k7ba3	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Diphtheria toxin, C-terminal domain	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
A	d7k7ba1	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
A	d7k7ba2	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Diphtheria toxin, middle domain	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
A	d7k7ba4	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
B	d7k7bb3	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Diphtheria toxin, C-terminal domain	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
B	d7k7bb1	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
B	d7k7bb2	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Diphtheria toxin, middle domain	automated matches	automated matches	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)
B	d7k7bb4	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Corynebacterium diphtheriae ) [TaxId: 1717 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Diphtheria_R	e7k7bA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Diphtheria_R	ECOD (1.6)
A	Diphtheria_T	e7k7bA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Diphtheria toxin, middle domain (From Topology)	T: Diphtheria toxin, middle domain	F: Diphtheria_T	ECOD (1.6)
A	Diphtheria_C	e7k7bA3	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Diphtheria_C	ECOD (1.6)
B	Diphtheria_R	e7k7bB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Diphtheria_R	ECOD (1.6)
B	Diphtheria_T	e7k7bB1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Diphtheria toxin, middle domain (From Topology)	T: Diphtheria toxin, middle domain	F: Diphtheria_T	ECOD (1.6)
B	Diphtheria_C	e7k7bB2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Diphtheria_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02764	Diphtheria toxin, T domain (Diphtheria_T)	Diphtheria toxin, T domain	Central domain of diphtheria toxin is the translocation (T) domain. pH induced conformational change in this domain triggers insertion into the endosomal membrane and facilitates the transfer of the catalytic domain into the cytoplasm.	Domain
A, B	PF01324	Diphtheria toxin, R domain (Diphtheria_R)	Diphtheria toxin, R domain	C-terminal receptor binding (R) domain - binds to cell surface receptor, permitting the toxin to enter the cell by receptor mediated endocytosis.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Diphtheria toxin	identical protein binding protein binding binding pentosyltransferase activity glycosyltransferase activity NAD+-diphthamide ADP-ribosyltransferase activity transferase activity catalytic activity toxin activity	-	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036799	Diphtheria toxin, receptor-binding domain superfamily	Homologous Superfamily
A, B	IPR000512	Diphtheria toxin (NAD+-dipthamide ADP-ribosyltransferase)	Family
A, B	IPR022404	Diphtheria toxin, receptor-binding domain	Domain
A, B	IPR036801	Diphtheria toxin, translocation domain superfamily	Homologous Superfamily
A, B	IPR022406	Diphtheria toxin, catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.