Annotations: 7K1H


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
FSCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
A [auth B]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
FPkinase_Tyre7k1hF1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
A [auth B]Pkinase_Tyre7k1hB1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
B [auth A]Pkinase_Tyre7k1hA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
CPkinase_Tyre7k1hC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
DPkinase_Tyre7k1hD1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
EPkinase_Tyre7k1hE1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Epidermal growth factor receptor

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptorFamily
IPR020635Tyrosine-protein kinase, catalytic domainDomain
IPR000719Protein kinase domainDomain
IPR032778Growth factor receptor domain 4Domain
IPR006212Furin-like repeatRepeat
IPR017441Protein kinase, ATP binding siteBinding Site
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
IPR008266Tyrosine-protein kinase, active siteActive Site
IPR036941Receptor L-domain superfamilyHomologous Superfamily
IPR049328Epidermal growth factor receptor-like, transmembrane-juxtamembrane segmentDomain
IPR000494Receptor L-domainDomain
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
IPR006211Furin-like cysteine-rich domainDomain
IPR050122Receptor Tyrosine KinaseFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP00533