6E8K

Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH2	e6e8kA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LeSH (Llo2327)	-	-	-
B	interleukin-2 receptor beta pTyr387 peptide	molecular transducer activity coreceptor activity signaling receptor activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity protein binding binding growth factor binding cytokine binding interleukin-2 binding interleukin-2 receptor activity interleukin-15 receptor activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process interleukin-2-mediated signaling pathway cellular response to interleukin-2 response to interleukin-2 negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization transport positive regulation of biological process vesicle-mediated transport localization positive regulation of endocytosis phagocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport endocytosis interleukin-15-mediated signaling pathway cellular response to interleukin-15 response to interleukin-15	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex interleukin-2 receptor complex receptor complex intracellular anatomical structure cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex interleukin-2 receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
B	IPR003531	Short hematopoietin receptor, family 1, conserved site	Conserved Site
B	IPR040951	Interleukin-2 receptor subunit beta, N-terminal	Domain
B	IPR003961	Fibronectin type III	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P14784	rheumatoid arthritis pneumonia juvenile idiopathic arthritis allergic disease oligoarticular juvenile idiopathic arthritis Liver Cirrhosis, Experimental acute myeloid leukemia tuberculosis celiac disease malignant mesothelioma neuroblastoma pneumonitis relapsing-remitting multiple sclerosis rheumatoid factor-negative juvenile idiopathic arthritis vitiligo rheumatoid arthritis pneumonia juvenile idiopathic arthritis allergic disease oligoarticular juvenile idiopathic arthritis Liver Cirrhosis, Experimental acute myeloid leukemia tuberculosis celiac disease malignant mesothelioma neuroblastoma pneumonitis relapsing-remitting multiple sclerosis rheumatoid factor-negative juvenile idiopathic arthritis vitiligo cutaneous lupus erythematosus Graves disease hypothyroidism large cell medulloblastoma lung cancer primary cutaneous T-cell lymphoma Sjogren syndrome bipolar disorder digestive system neuroendocrine neoplasm Hashimoto thyroiditis interstitial cystitis lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.