6QL9

Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)
CSCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)
DSCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)
ESCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)
FSCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)
BSCOP2B Superfamily4'-phosphopantetheinyl transferase 8074379 3000948 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFabG2_1ste6ql9A7 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
AFabG2_2nde6ql9A5 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
AACPS_1e6ql9A2 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Aadh_short_C2e6ql9A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Aketoacyl-synte6ql9A3 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
AKetoacyl-synt_C_2e6ql9A4 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
CFabG2_1ste6ql9C7 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
CFabG2_2nde6ql9C6 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
CACPS_1e6ql9C1 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Cadh_short_C2e6ql9C4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Cketoacyl-synte6ql9C5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
CKetoacyl-synt_C_2e6ql9C3 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
DFabG2_1ste6ql9D4 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
DFabG2_2nde6ql9D7 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
DACPS_1e6ql9D5 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Dadh_short_C2e6ql9D6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Dketoacyl-synte6ql9D1 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
DKetoacyl-synt_C_2e6ql9D2 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
EFabG2_1ste6ql9E3 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
EFabG2_2nde6ql9E5 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
EACPS_1e6ql9E4 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Eadh_short_C2e6ql9E6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Eketoacyl-synte6ql9E7 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
EKetoacyl-synt_C_2e6ql9E1 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
FFabG2_1ste6ql9F2 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
FFabG2_2nde6ql9F7 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
FACPS_1e6ql9F3 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Fadh_short_C2e6ql9F5 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Fketoacyl-synte6ql9F4 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
FKetoacyl-synt_C_2e6ql9F6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
BFabG2_1ste6ql9B6 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: FabG2_1stECOD (1.6)
BFabG2_2nde6ql9B3 A: alpha complex topologyX: FAS type I helical domain (From Topology)H: FAS type I helical domain (From Topology)T: FAS type I helical domainF: FabG2_2ndECOD (1.6)
BACPS_1e6ql9B2 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPS_1ECOD (1.6)
Badh_short_C2e6ql9B1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Bketoacyl-synte6ql9B7 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
BKetoacyl-synt_C_2e6ql9B5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_C_2ECOD (1.6)
GEUF08073e6ql9G6 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
GDUF1729e6ql9G4 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
GMaoC_dehydratase6ql9G1 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
GMaoC_dehydrat_Ne6ql9G8 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
GFAS1_thioest_inse6ql9G10 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
GAcyl_transf_1_1st_1e6ql9G5 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
GFabD_1st_1e6ql9G7 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
GCOG4981_1e6ql9G11 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
GNMOe6ql9G2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
GAcyl_transf_1_1ste6ql9G3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
JEUF08073e6ql9J4 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
JDUF1729e6ql9J3 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
JMaoC_dehydratase6ql9J6 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
JMaoC_dehydrat_Ne6ql9J1 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
JFAS1_thioest_inse6ql9J5 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
JAcyl_transf_1_1st_1e6ql9J7 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
JFabD_1st_1e6ql9J2 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
JCOG4981_1e6ql9J10 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
JNMOe6ql9J9 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
JAcyl_transf_1_1ste6ql9J8 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
HEUF08073e6ql9H11 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
HDUF1729e6ql9H9 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
HMaoC_dehydratase6ql9H6 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
HMaoC_dehydrat_Ne6ql9H10 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
HFAS1_thioest_inse6ql9H4 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
HAcyl_transf_1_1st_1e6ql9H8 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
HFabD_1st_1e6ql9H1 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
HCOG4981_1e6ql9H2 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
HNMOe6ql9H7 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
HAcyl_transf_1_1ste6ql9H3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
IEUF08073e6ql9I1 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
IDUF1729e6ql9I6 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
IMaoC_dehydratase6ql9I7 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
IMaoC_dehydrat_Ne6ql9I9 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
IFAS1_thioest_inse6ql9I10 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
IAcyl_transf_1_1st_1e6ql9I4 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
IFabD_1st_1e6ql9I5 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
ICOG4981_1e6ql9I2 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
INMOe6ql9I11 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
IAcyl_transf_1_1ste6ql9I3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
KEUF08073e6ql9K3 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
KDUF1729e6ql9K8 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
KMaoC_dehydratase6ql9K5 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
KMaoC_dehydrat_Ne6ql9K10 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
KFAS1_thioest_inse6ql9K6 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
KAcyl_transf_1_1st_1e6ql9K4 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
KFabD_1st_1e6ql9K2 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
KCOG4981_1e6ql9K1 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
KNMOe6ql9K7 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
KAcyl_transf_1_1ste6ql9K9 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
LEUF08073e6ql9L4 A: alpha bundlesX: N-terminal domain in fatty acid synthase subunit beta (From Topology)H: N-terminal domain in fatty acid synthase subunit beta (From Topology)T: N-terminal domain in fatty acid synthase subunit betaF: EUF08073ECOD (1.6)
LDUF1729e6ql9L8 A: alpha bundlesX: Inserted helical domain in fatty acid synthase subunit beta (From Topology)H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)T: Inserted helical domain in fatty acid synthase subunit betaF: DUF1729ECOD (1.6)
LMaoC_dehydratase6ql9L2 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydratasECOD (1.6)
LMaoC_dehydrat_Ne6ql9L5 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Thioesterase/thiol ester dehydrase-isomerase (From Topology)T: Thioesterase/thiol ester dehydrase-isomeraseF: MaoC_dehydrat_NECOD (1.6)
LFAS1_thioest_inse6ql9L9 A: a+b two layersX: Thioesterase/thiol ester dehydrase-isomerase-likeH: Insertion domain in thioesterase (From Topology)T: Insertion domain in thioesteraseF: FAS1_thioest_insECOD (1.6)
LAcyl_transf_1_1st_1e6ql9L1 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_1st_1ECOD (1.6)
LFabD_1st_1e6ql9L6 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: FabD_1st_1ECOD (1.6)
LCOG4981_1e6ql9L3 A: a+b two layersX: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)T: Meander beta sheet domain in fatty acid synthase subunit betaF: COG4981_1ECOD (1.6)
LNMOe6ql9L7 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: NMOECOD (1.6)
LAcyl_transf_1_1ste6ql9L10 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02801Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)Beta-ketoacyl synthase, C-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.Domain
A, B, C, D, E
PF016484'-phosphopantetheinyl transferase superfamily (ACPS)4'-phosphopantetheinyl transferase superfamilyMembers of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of ...Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.
Domain
A, B, C, D, E
PF00109Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)Beta-ketoacyl synthase, N-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].
Domain
A, B, C, D, E
PF18325Fatty acid synthase subunit alpha Acyl carrier domain (Fas_alpha_ACP)Fatty acid synthase subunit alpha Acyl carrier domainThis is the acyl carrier domain (ACP) found in fatty acid synthase subunit alpha (FAS2) EC:2.3.1.86 .The fungal type I fatty acid synthase (FAS) is a 2.6 MDa multienzyme complex, catalyzing all necessary steps for the synthesis of long acyl chains. T ...This is the acyl carrier domain (ACP) found in fatty acid synthase subunit alpha (FAS2) EC:2.3.1.86 .The fungal type I fatty acid synthase (FAS) is a 2.6 MDa multienzyme complex, catalyzing all necessary steps for the synthesis of long acyl chains. To be catalytically competent, the FAS must be activated by a posttranslational modification of the central acyl carrier domain (ACP) by an intrinsic phosphopantetheine transferase (PPT) [1].
Domain
A, B, C, D, E
PF18314Fatty acid synthase type I helical domain (FAS_I_H)Fatty acid synthase type I helical domainThis domain is found in the fatty acid synthase (FAS) complex present in species such as Mycobacterium smegmatis and Thermomyces lanuginosus. FAS is a homo-hexameric enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids. This doma ...This domain is found in the fatty acid synthase (FAS) complex present in species such as Mycobacterium smegmatis and Thermomyces lanuginosus. FAS is a homo-hexameric enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids. This domain is composed of dimerization module 1 (DM1) and four-helix bundle (4HB), both of which are conserved parts of the acetyl transferase [1].
Domain
G, J
PF17828N-terminal domain in fatty acid synthase subunit beta (FAS_N)N-terminal domain in fatty acid synthase subunit betaThis entry represents the N-terminal domain found in fatty acid synthase proteins such as Swiss:P07149.Domain
G, J
PF16073Starter unit:ACP transacylase in aflatoxin biosynthesis (SAT)Starter unit:ACP transacylase in aflatoxin biosynthesis- Family
G, J
PF08354Fatty acid synthase subunit beta/Fas1-like, helical (Fas1-AflB-like_hel)Fatty acid synthase subunit beta/Fas1-like, helicalThis domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and ...This domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and is found together with the MaoC-like domain (Pfam:PF01575) and the acyltransferase domain (Pfam:PF00698) [1]. Fas1 is a fatty acid synthetase that catalyses the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH [2]. AflB is part of the gene cluster that mediates the biosynthesis of aflatoxins [3].
Domain
G, J
PF22235Fatty acid synthase subunit beta, insertion domain (FAS1_thioest_ins)Fatty acid synthase subunit beta, insertion domainThis entry represents the insertion domain in the thioesterase of fatty acid synthases from fungi and related sequences [1-3].Domain
G, J
PF13452FAS1-like, dehydratase domain region (FAS1_DH_region)N-terminal half of MaoC dehydrataseIt is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher euka ...It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.
Domain
G, J
PF17951Fatty acid synthase meander beta sheet domain (FAS_meander)Fatty acid synthase meander beta sheet domainThis domain is found in fungal fatty acid synthase beta chain proteins [3].Domain
G, J
PF01575MaoC like domain (MaoC_dehydratas)MaoC like domainThe maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydroge ...The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.
Domain
G, J
PF00698Acyl transferase domain (Acyl_transf_1)Acyl transferase domain- Domain
H, I, K, L
PF17828N-terminal domain in fatty acid synthase subunit beta (FAS_N)N-terminal domain in fatty acid synthase subunit betaThis entry represents the N-terminal domain found in fatty acid synthase proteins such as Swiss:P07149.Domain
H, I, K, L
PF16073Starter unit:ACP transacylase in aflatoxin biosynthesis (SAT)Starter unit:ACP transacylase in aflatoxin biosynthesis- Family
H, I, K, L
PF08354Fatty acid synthase subunit beta/Fas1-like, helical (Fas1-AflB-like_hel)Fatty acid synthase subunit beta/Fas1-like, helicalThis domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and ...This domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and is found together with the MaoC-like domain (Pfam:PF01575) and the acyltransferase domain (Pfam:PF00698) [1]. Fas1 is a fatty acid synthetase that catalyses the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH [2]. AflB is part of the gene cluster that mediates the biosynthesis of aflatoxins [3].
Domain
H, I, K, L
PF22235Fatty acid synthase subunit beta, insertion domain (FAS1_thioest_ins)Fatty acid synthase subunit beta, insertion domainThis entry represents the insertion domain in the thioesterase of fatty acid synthases from fungi and related sequences [1-3].Domain
H, I, K, L
PF13452FAS1-like, dehydratase domain region (FAS1_DH_region)N-terminal half of MaoC dehydrataseIt is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher euka ...It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.
Domain
H, I, K, L
PF17951Fatty acid synthase meander beta sheet domain (FAS_meander)Fatty acid synthase meander beta sheet domainThis domain is found in fungal fatty acid synthase beta chain proteins [3].Domain
H, I, K, L
PF01575MaoC like domain (MaoC_dehydratas)MaoC like domainThe maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydroge ...The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.
Domain
H, I, K, L
PF00698Acyl transferase domain (Acyl_transf_1)Acyl transferase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Fatty acid synthase subunit alpha
G, J
Fatty acid synthase subunit beta
H, I, K, L
Fatty acid synthase subunit beta

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
A, B, C, D, E
IPR014031Beta-ketoacyl synthase, C-terminalDomain
A, B, C, D, E
IPR002582Holo-[acyl carrier protein] synthaseFamily
A, B, C, D, E
IPR040899Fatty acid synthase subunit alpha, acyl carrier domainDomain
A, B, C, D, E
IPR0371434'-phosphopantetheinyl transferase domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
A, B, C, D, E
IPR009081Phosphopantetheine binding ACP domainDomain
A, B, C, D, E
IPR041550Fatty acid synthase type I, helicalDomain
A, B, C, D, E
IPR026025Fatty acid synthase alpha subunit, yeastFamily
A, B, C, D, E
IPR0082784'-phosphopantetheinyl transferase domainDomain
A, B, C, D, E
IPR050830Fungal fatty acid synthaseFamily
A, B, C, D, E
IPR016039Thiolase-likeHomologous Superfamily
A, B, C, D, E
IPR047224Fatty acid synthase subunit alpha-like, C-terminalDomain
A, B, C, D, E
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR018201Beta-ketoacyl synthase, active siteActive Site
A, B, C, D, E
IPR014030Beta-ketoacyl synthase-like, N-terminalDomain
A, B, C, D, E
IPR004568Phosphopantetheine-protein transferase domainDomain
G, J
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
G, J
IPR003965Fatty acid synthaseDomain
G, J
IPR013785Aldolase-type TIM barrelHomologous Superfamily
G, J
IPR039569FAS1-like, dehydratase domain regionDomain
G, J
IPR040883Fatty acid synthase, meander beta sheet domainDomain
G, J
IPR032088Starter unit:ACP transacylaseDomain
G, J
IPR014043Acyl transferase domainDomain
G, J
IPR041099Fatty acid synthase subunit beta, N-terminal domainDomain
G, J
IPR029069HotDog domain superfamilyHomologous Superfamily
G, J
IPR050830Fungal fatty acid synthaseFamily
G, J
IPR002539MaoC-like dehydratase domainDomain
G, J
IPR001227Acyl transferase domain superfamilyHomologous Superfamily
G, J
IPR013565Fatty acid synthase beta subunit AflB /Fas1-like, central domainDomain
G, J
IPR016452Fatty acid synthase beta subunit AflB /Fas1-like, fungiFamily
H, I, K, L
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
H, I, K, L
IPR003965Fatty acid synthaseDomain
H, I, K, L
IPR013785Aldolase-type TIM barrelHomologous Superfamily
H, I, K, L
IPR039569FAS1-like, dehydratase domain regionDomain
H, I, K, L
IPR040883Fatty acid synthase, meander beta sheet domainDomain
H, I, K, L
IPR032088Starter unit:ACP transacylaseDomain
H, I, K, L
IPR014043Acyl transferase domainDomain
H, I, K, L
IPR041099Fatty acid synthase subunit beta, N-terminal domainDomain
H, I, K, L
IPR029069HotDog domain superfamilyHomologous Superfamily
H, I, K, L
IPR050830Fungal fatty acid synthaseFamily
H, I, K, L
IPR002539MaoC-like dehydratase domainDomain
H, I, K, L
IPR001227Acyl transferase domain superfamilyHomologous Superfamily
H, I, K, L
IPR013565Fatty acid synthase beta subunit AflB /Fas1-like, central domainDomain
H, I, K, L
IPR016452Fatty acid synthase beta subunit AflB /Fas1-like, fungiFamily