Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
O [auth P]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
R [auth T]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
S [auth V]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
P [auth Q]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
Q [auth S]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)
T [auth W]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038367 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe6chtA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
BHormone_recepe6chtB1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
DHormone_recepe6chtD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
EHormone_recepe6chtE1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
HHormone_recepe6chtH1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
JHormone_recepe6chtJ1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
KHormone_recepe6chtK1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
MHormone_recepe6chtM1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
O [auth P]Hormone_recepe6chtP1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
R [auth T]Hormone_recepe6chtT1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
S [auth V]Hormone_recepe6chtV1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
GHormone_recepe6chtG1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
NHormone_recepe6chtN1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
P [auth Q]Hormone_recepe6chtQ1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
Q [auth S]Hormone_recepe6chtS1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
T [auth W]Hormone_recepe6chtW1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (utative)
B1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
D1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (utative)
E1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
H1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
J1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (utative)
K1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
M1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
O [auth P]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
R [auth T]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
S [auth V]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
G1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (utative)
N1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
P [auth Q]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
Q [auth S]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
T [auth W]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B,
D,
E,
G,
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B,
D,
E,
G,
Hepatocyte nuclear factor 4-alpha
C, F, I, L
Proliferation-associated protein 2G4

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
B,
D,
E,
G,
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A,
B,
D,
E,
G,
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A,
B,
D,
E,
G,
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
A,
B,
D,
E,
G,
IPR001723Nuclear hormone receptorFamily
A,
B,
D,
E,
G,
IPR049635Hepatocyte nuclear factor 4, ligand-binding domainDomain
A,
B,
D,
E,
G,
IPR049636Hepatocyte nuclear factor 4-like, DNA-binding domainDomain
A,
B,
D,
E,
G,
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A,
B,
D,
E,
G,
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
C, F, I, L
IPR036388Winged helix-like DNA-binding domain superfamilyHomologous Superfamily
C, F, I, L
IPR047113Proliferation-associated protein 2G4/ARX1Family
C, F, I, L
IPR036390Winged helix DNA-binding domain superfamilyHomologous Superfamily
C, F, I, L
IPR018349Peptidase M24A, methionine aminopeptidase, subfamily 2, binding siteBinding Site
C, F, I, L
IPR036005Creatinase/aminopeptidase-likeHomologous Superfamily
C, F, I, L
IPR004545PA2G4 familyFamily
C, F, I, L
IPR000994Peptidase M24Domain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
B,
D,
E,
G,
PharosP41235
C, F, I, L
PharosQ9UQ80