Annotations: 5XYF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e5xyfA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14973	TERF1-interacting nuclear factor 2 N-terminus (TINF2_N)	TERF1-interacting nuclear factor 2 N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TERF1-interacting nuclear factor 2	sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding	regulation of molecular function regulation of catalytic activity negative regulation of transferase activity biological regulation negative regulation of molecular function negative regulation of catalytic activity regulation of transferase activity negative regulation of protein ADP-ribosylation regulation of protein ADP-ribosylation protein localization localization cellular localization protein localization to chromosome protein localization to organelle regulation of molecular function regulation of catalytic activity negative regulation of transferase activity biological regulation negative regulation of molecular function negative regulation of catalytic activity regulation of transferase activity negative regulation of protein ADP-ribosylation regulation of protein ADP-ribosylation protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cellular process protein localization to chromosome, telomeric region regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of primary metabolic process telomere maintenance via telomere lengthening cellular component organization nucleobase-containing compound metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process regulation of biological process chromosome organization primary metabolic process DNA metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleic acid metabolic process regulation of organelle organization telomere maintenance organelle organization metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere capping negative regulation of cell population proliferation cell population proliferation negative regulation of biological process regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation cellular component biogenesis cellular component assembly telomere assembly negative regulation of telomere maintenance negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process negative regulation of cellular component organization negative regulation of metabolic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process negative regulation of DNA biosynthetic process negative regulation of telomere maintenance via telomere lengthening nucleic acid biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process telomere maintenance via telomerase nucleobase-containing compound biosynthetic process macromolecule biosynthetic process regulation of telomere maintenance via telomerase negative regulation of organelle organization negative regulation of biosynthetic process negative regulation of DNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix membraneless organelle intracellular membraneless organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix membraneless organelle intracellular membraneless organelle perinucleolar chromocenter chromocenter protein-containing complex protein-DNA complex nuclear protein-containing complex chromosome chromosomal region telomere cap complex chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex nuclear body nucleoplasm
B [auth C]	Telomeric repeat-binding factor 2	sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding protein-containing complex binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding protein binding sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding protein-containing complex binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding protein binding protein homodimerization activity protein dimerization activity enzyme binding	positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function positive regulation of monooxygenase activity regulation of catalytic activity regulation of nitric-oxide synthase activity biological regulation positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function positive regulation of monooxygenase activity regulation of catalytic activity regulation of nitric-oxide synthase activity biological regulation positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of DNA biosynthetic process regulation of primary metabolic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleobase-containing compound metabolic process nucleic acid biosynthetic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of biological process telomere maintenance via telomerase chromosome organization primary metabolic process DNA metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of organelle organization regulation of telomere maintenance via telomerase telomere maintenance organelle organization biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process regulation of DNA metabolic process positive regulation of biological process gene expression positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process cellular response to stimulus cellular response to stress response to stimulus response to stress cellular senescence developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development single strand break repair regulation of cellular response to stress negative regulation of biological process negative regulation of DNA repair regulation of response to stress negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process DNA repair negative regulation of macromolecule metabolic process regulation of single strand break repair negative regulation of response to stimulus negative regulation of metabolic process negative regulation of telomere single strand break repair regulation of DNA repair negative regulation of single strand break repair DNA damage response regulation of response to stimulus telomere single strand break repair negative regulation of DNA metabolic process negative regulation of telomere maintenance negative regulation of chromosome organization negative regulation of cellular component organization negative regulation of organelle organization telomeric loop disassembly regulation of telomeric loop disassembly telomeric D-loop disassembly regulation of telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of telomeric loop disassembly protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region positive regulation of organelle organization positive regulation of cellular component organization positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere maintenance in response to DNA damage protection from non-homologous end joining at telomere telomere capping negative regulation of telomere capping regulation of telomere capping transport intracellular transport axonal transport establishment of localization axo-dendritic transport axonal transport of messenger ribonucleoprotein complex establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process telomeric loop formation negative regulation of hydrolase activity negative regulation of beta-galactosidase activity regulation of hydrolase activity negative regulation of molecular function negative regulation of catalytic activity regulation of t-circle formation cellular component biogenesis cellular component assembly formation of extrachromosomal circular DNA regulation of cellular component biogenesis negative regulation of t-circle formation telomere maintenance via telomere trimming t-circle formation negative regulation of telomere maintenance via telomerase negative regulation of macromolecule biosynthetic process negative regulation of DNA biosynthetic process negative regulation of telomere maintenance via telomere lengthening negative regulation of biosynthetic process regulation of cellular senescence negative regulation of cellular senescence negative regulation of telomere maintenance via semi-conservative replication negative regulation of cell cycle cell cycle DNA replication telomere maintenance via semi-conservative replication cell cycle regulation of cell cycle process DNA replication nuclear DNA replication regulation of cell cycle cell cycle process DNA-templated DNA replication negative regulation of cell cycle process regulation of telomere maintenance via semi-conservative replication negative regulation of gene expression negative regulation of exonuclease activity negative regulation of nuclease activity regulation of DNA recombination regulation of telomere maintenance via recombination regulation of DNA recombination at telomere regulation of mitotic recombination negative regulation of telomere maintenance via recombination telomere maintenance via recombination negative regulation of DNA recombination at telomere negative regulation of mitotic recombination DNA recombination mitotic recombination negative regulation of DNA recombination	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus intracellular membraneless organelle nuclear protein-containing complex chromosome intracellular membrane-bounded organelle chromosomal region intracellular organelle cellular anatomical structure organelle telomere cap complex membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus intracellular membraneless organelle nuclear protein-containing complex chromosome intracellular membrane-bounded organelle chromosomal region intracellular organelle cellular anatomical structure organelle telomere cap complex membraneless organelle chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex axon cell projection neuron projection plasma membrane bounded cell projection male germ cell nucleus germ cell nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body
C [auth B]	Adrenocortical dysplasia protein homolog	sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding protein-containing complex binding enzyme regulator activity RNA-directed DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity enzyme inhibitor activity nucleotidyltransferase activity telomerase inhibitor activity transferase activity, transferring phosphorus-containing groups sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding protein-containing complex binding enzyme regulator activity RNA-directed DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity enzyme inhibitor activity nucleotidyltransferase activity telomerase inhibitor activity transferase activity, transferring phosphorus-containing groups telomerase activity molecular function inhibitor activity catalytic activity, acting on DNA DNA polymerase activity molecular function regulator activity catalytic activity protein binding DNA polymerase binding enzyme binding	telomere maintenance via telomerase telomere organization chromosome organization primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance cellular component organization nucleic acid biosynthetic process organelle organization telomere maintenance via telomerase telomere organization chromosome organization primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance cellular component organization nucleic acid biosynthetic process organelle organization biosynthetic process metabolic process cellular process macromolecule metabolic process cellular component organization or biogenesis DNA biosynthetic process developmental process multicellular organism development multicellular organismal process segmentation anatomical structure development pattern specification process regionalization skeletal system development system development urogenital system development cellular component biogenesis cellular component assembly telomere assembly limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development anatomical structure morphogenesis appendage morphogenesis limb morphogenesis negative regulation of telomere maintenance regulation of cellular process negative regulation of biological process negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process regulation of primary metabolic process negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process negative regulation of cellular component organization negative regulation of metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization negative regulation of telomere maintenance via telomere lengthening negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process regulation of telomere maintenance via telomerase negative regulation of organelle organization negative regulation of biosynthetic process negative regulation of DNA metabolic process establishment of protein localization to telomere protein localization regulation of localization establishment of protein localization cellular localization regulation of protein localization localization regulation of protein localization to chromosome, telomeric region cellular macromolecule localization establishment of protein localization to chromosome regulation of establishment of protein localization to chromosome regulation of establishment of protein localization protein localization to chromosome, telomeric region establishment of localization establishment of protein localization to organelle protein localization to chromosome regulation of cellular localization regulation of establishment of protein localization to telomere macromolecule localization protein localization to organelle nitrogen compound transport transport intracellular transport protein transport establishment of localization in cell intracellular protein transport positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus protection from non-homologous end joining at telomere cellular response to stress telomere capping DNA damage response response to stress	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle telomerase holoenzyme complex cellular anatomical structure organelle ribonucleoprotein complex protein-DNA complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle telomerase holoenzyme complex cellular anatomical structure organelle ribonucleoprotein complex protein-DNA complex intracellular membraneless organelle chromosome chromosomal region telomere cap complex membraneless organelle chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029400	TERF1-interacting nuclear factor 2, N-terminal domain	Domain
A	IPR039098	TERF1-interacting nuclear factor 2	Family
B [auth C]	IPR009057	Homedomain-like superfamily	Homologous Superfamily
B [auth C]	IPR017357	Telomeric repeat-binding factor 1/2	Family
B [auth C]	IPR031902	Telomeric repeat-binding factor 2, Rap1-binding domain	Domain
B [auth C]	IPR030657	Telomeric repeat-binding factor 2	Family
B [auth C]	IPR017930	Myb domain	Domain
B [auth C]	IPR013867	Telomere repeat-binding factor, dimerisation domain	Domain
B [auth C]	IPR036507	Telomere repeat-binding factor, dimerisation domain superfamily	Homologous Superfamily
B [auth C]	IPR001005	SANT/Myb domain	Domain
C [auth B]	IPR028631	Adrenocortical dysplasia protein	Family
C [auth B]	IPR019437	Shelterin complex subunit TPP1/Est3	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BSI4	dyskeratosis congenita Revesz syndrome dyskeratosis congenita, autosomal dominant 3 nail disease bone marrow disease Hoyeraal-Hreidarsson syndrome cerebellar disease dyskeratosis congenita, autosomal dominant 1 aplastic anemia Cerebellar Hypoplasia hematopoietic and lymphoid system neoplasm idiopathic pulmonary fibrosis tuberculosis congenital anemia genetic endocrine growth disease dyskeratosis congenita Revesz syndrome dyskeratosis congenita, autosomal dominant 3 nail disease bone marrow disease Hoyeraal-Hreidarsson syndrome cerebellar disease dyskeratosis congenita, autosomal dominant 1 aplastic anemia Cerebellar Hypoplasia hematopoietic and lymphoid system neoplasm idiopathic pulmonary fibrosis tuberculosis congenital anemia genetic endocrine growth disease intellectual disability ovarian cancer idiopathic aplastic anemia language disorder
B [auth C]	Pharos: Q15554	adult T-cell leukemia/lymphoma acute T cell leukemia psoriasis subependymal giant cell astrocytoma osteosarcoma tuberculosis
C [auth B]	Pharos: Q96AP0	dyskeratosis congenita, autosomal dominant 6 dyskeratosis congenita familial melanoma Hoyeraal-Hreidarsson syndrome gastric carcinoma osteosarcoma DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 7 hematopoietic and lymphoid system neoplasm subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.