5XGI
Crystal structure of PI3K complex with an inhibitor
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | PI3K_P85_iSH2 | e5xgiB2 | A: alpha bundles | X: YscO-like | H: Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain (From Topology) | T: Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | F: PI3K_P85_iSH2 | ECOD (1.6) |
B | SH2 | e5xgiB1 | A: a+b two layers | X: SH2 (From Topology) | H: SH2 (From Topology) | T: SH2 | F: SH2 | ECOD (1.6) |
A | PI3K_C2 | e5xgiA2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: C2 domain (From Topology) | T: C2 domain | F: PI3K_C2 | ECOD (1.6) |
A | PI3Ka | e5xgiA3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PI3Ka | ECOD (1.6) |
A | PI3K_rbd | e5xgiA5 | A: a+b two layers | X: beta-Grasp | H: Ubiquitin-related | T: Ubiquitin-like | F: PI3K_rbd | ECOD (1.6) |
A | PI3K_p85B | e5xgiA1 | A: a+b two layers | X: beta-Grasp | H: Ubiquitin-related | T: Ubiquitin-like | F: PI3K_p85B | ECOD (1.6) |
A | PI3_PI4_kinase | e5xgiA4 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: PI3_PI4_kinase | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00017 | SH2 domain (SH2) | SH2 domain | - | Domain | |
PF16454 | Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain (PI3K_P85_iSH2) | Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain | This domain is found between the two SH2 domains in phosphatidylinositol 3-kinase regulatory subunit P85. It forms a complex with the adaptor-binding domain of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha [1]. | Domain | |
PF00613 | Phosphoinositide 3-kinase family, accessory domain (PIK domain) (PI3Ka) | Phosphoinositide 3-kinase family, accessory domain (PIK domain) | - | Repeat | |
PF02192 | PI3-kinase family, p85-binding domain (PI3K_p85B) | PI3-kinase family, p85-binding domain | - | Family | |
PF00792 | Phosphoinositide 3-kinase C2 (PI3K_C2) | Phosphoinositide 3-kinase C2 | Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family. | Domain | |
PF00794 | PI3-kinase family, ras-binding domain (PI3K_rbd) | PI3-kinase family, ras-binding domain | Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation). | Domain | |
PF00454 | Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase) | Phosphatidylinositol 3- and 4-kinase | - | Family |