5U9I

Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FKBP_C	e5u9iA1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity unfolded protein binding protein binding binding farnesylated protein binding	multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis detection of light stimulus response to light stimulus phototransduction cellular response to stimulus detection of external stimulus regulation of biological process regulation of cellular process response to stimulus multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis detection of light stimulus response to light stimulus phototransduction cellular response to stimulus detection of external stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation detection of visible light response to external stimulus detection of abiotic stimulus cell communication detection of stimulus response to abiotic stimulus response to radiation cellular process signal transduction phototransduction, visible light negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death sensory perception of light stimulus system process sensory perception nervous system process visual perception regulation of response to external stimulus regulation of opsin-mediated signaling pathway regulation of signal transduction cellular response to environmental stimulus cellular response to light stimulus regulation of G protein-coupled receptor signaling pathway regulation of signaling cellular response to radiation regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular response to abiotic stimulus G protein-coupled opsin signaling pathway protein farnesylation macromolecule modification protein prenylation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process prenylation protein modification process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen photoreceptor inner segment cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR039663	AIP/AIPL1/TTC9	Family
A	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NZN9	Leber congenital amaurosis Leber congenital amaurosis 4 retinitis pigmentosa cone-rod dystrophy attention deficit hyperactivity disorder, inattentive type inherited retinal dystrophy intellectual disability malignant glioma Retinitis Pigmentosa, Juvenile, Aipl1-Related medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.