Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidic acid (06:0 PA)
External Resource: Annotation
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
B [auth L] | C1-set | e5t80L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
B [auth L] | V-set_3 | e5t80L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
C [auth G] | PTS_EIIA_2 | e5t80G1 | A: a+b three layers | X: Phoshotransferase/anion transport protein (From Topology) | H: Phoshotransferase/anion transport protein (From Topology) | T: Phoshotransferase/anion transport protein | F: PTS_EIIA_2 | ECOD (1.6) |
A [auth H] | C1-set_1 | e5t80H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
A [auth H] | V-set_12 | e5t80H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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B [auth L] | Fab 10E8, broadly neutralizing | L-LAMBDA | Homo sapiens (human) | IGLV3-19*01, IGLJ2*01, IGLJ3*02, IGLJ3*01, IGLC2*01, IGLC2*02, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_LAMBDA | IMGT (202448-0) |
A [auth H] | Fab 10E8, broadly neutralizing | VH-CH1 | Homo sapiens (human) | IGHV3-15*01, IGHV3-15*04, IGHV3-15*05, IGHV3-15*07, IGHJ1*01, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_LAMBDA | IMGT (202448-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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B [auth L] | Light Chain | IGLV3 | Lambda | 10e8 epitope scaffold t117v2 | SAbDab (2024-12-06) |
A [auth H] | Heavy Chain | IGHV3 | - | 10e8 epitope scaffold t117v2 | SAbDab (2024-12-06) |