5F6L | pdb_00005f6l

The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SPRY	e5f6lB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: SPRY	ECOD (1.6)
C [auth A]	SET	e5f6lA1	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: SET	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.120.920	Mainly Beta	Sandwich	Jelly Rolls	SPRY domain	CATH (4.3.0)
C [auth A]	2.170.270.10	Mainly Beta	Beta Complex	Beta-clip-like	SET domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00622	SPRY domain (SPRY)	SPRY domain	SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of ...	SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development [1,2,3,4]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region [2]. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologues are domains in butyrophilin/ marenostrin/pyrin [1].	Domain
C [auth A]	PF00856	SET domain (SET)	SET domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth J]	Retinoblastoma-binding protein 5	protein binding binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process regulation of biological process epigenetic regulation of gene expression biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process response to hormone response to endogenous stimulus response to chemical response to estrogen	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex histone methyltransferase complex catalytic complex nuclear protein-containing complex transferase complex nucleoplasm methyltransferase complex Set1C/COMPASS complex MLL1/2 complex MLL3/4 complex MLL1 complex
B	Set1/Ash2 histone methyltransferase complex subunit ASH2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding beta-catenin binding protein binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process response to hormone response to endogenous stimulus response to chemical response to estrogen developmental process cellular developmental process hemopoiesis cell differentiation anatomical structure development cell development positive regulation of DNA-templated transcription regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen Set1C/COMPASS complex euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome MLL1/2 complex MLL3/4 complex MLL1 complex
C [auth A]	Histone-lysine N-methyltransferase 2A	sequence-specific DNA binding DNA binding binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity sequence-specific DNA binding DNA binding binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity histone H3K4 trimethyltransferase activity S-methyltransferase activity protein-cysteine methyltransferase activity histone H3K4 monomethyltransferase activity DNA secondary structure binding minor groove of adenine-thymine-rich DNA binding identical protein binding protein binding modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding chromatin binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process regulation of biological process epigenetic regulation of gene expression biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process behavior multicellular organismal process exploration behavior macromolecule modification protein metabolic process protein modification process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells methylation apoptotic process cell death programmed cell death response to stimulus response to potassium ion response to metal ion response to chemical rhythmic process circadian regulation of gene expression circadian rhythm developmental process cellular developmental process hemopoiesis animal organ development cell development embryo development multicellular organism development embryonic hemopoiesis cell differentiation anatomical structure development embryonic organ development immune system development spleen development immune system process hematopoietic or lymphoid organ development system development fibroblast proliferation cell population proliferation negative regulation of cell population proliferation negative regulation of biological process regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of fibroblast proliferation definitive hemopoiesis positive regulation of DNA-templated transcription regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular response to endogenous stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to endogenous stimulus response to growth factor response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of short-term neuronal synaptic plasticity regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation type 2 immune response T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T-helper 2 cell differentiation T cell differentiation lymphocyte activation involved in immune response immune response T-helper cell differentiation cell activation T cell differentiation involved in immune response immune effector process leukocyte differentiation membrane depolarization regulation of membrane potential post-embryonic development anterior/posterior pattern specification pattern specification process regionalization regulation of cellular component organization negative regulation of DNA methylation-dependent heterochromatin formation negative regulation of heterochromatin formation negative regulation of chromatin organization negative regulation of macromolecule metabolic process regulation of heterochromatin formation regulation of chromatin organization heterochromatin formation negative regulation of cellular component organization negative regulation of metabolic process negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process DNA methylation-dependent constitutive heterochromatin formation negative regulation of gene expression, epigenetic	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol MLL1/2 complex MLL1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth J]	IPR037850	Retinoblastoma-binding protein 5/Swd1	Family
A [auth J]	IPR001680	WD40 repeat	Repeat
A [auth J]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR053835	Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix	Domain
B	IPR001870	B30.2/SPRY domain	Domain
B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
B	IPR049455	Set1/Ash2 histone methyltransferase complex subunit ASH2-like, PHD zinc finger	Domain
B	IPR037353	Histone methyltransferase complex subunit ASH2	Family
B	IPR003877	SPRY domain	Domain
C [auth A]	IPR001965	Zinc finger, PHD-type	Domain
C [auth A]	IPR046341	SET domain superfamily	Homologous Superfamily
C [auth A]	IPR001214	SET domain	Domain
C [auth A]	IPR044133	KMT2A, PHD domain 3	Domain
C [auth A]	IPR003616	Post-SET domain	Domain
C [auth A]	IPR034732	Extended PHD (ePHD) domain	Domain
C [auth A]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C [auth A]	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
C [auth A]	IPR003888	FY-rich, N-terminal	Conserved Site
C [auth A]	IPR001487	Bromodomain	Domain
C [auth A]	IPR002857	Zinc finger, CXXC-type	Domain
C [auth A]	IPR019787	Zinc finger, PHD-finger	Domain
C [auth A]	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
C [auth A]	IPR041958	KMT2A, ePHD domain	Domain
C [auth A]	IPR047219	Histone-lysine N-methyltransferase 2A/2B, SET domain	Domain
C [auth A]	IPR042025	KMT2A, PHD domain 2	Domain
C [auth A]	IPR003889	FY-rich, C-terminal	Conserved Site
C [auth A]	IPR016569	Methyltransferase, trithorax	Family
C [auth A]	IPR042023	KMT2A, PHD domain 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth J]	Pharos: Q15291	attention deficit hyperactivity disorder, inattentive type Pick disease atypical teratoid rhabdoid tumor psoriasis cutaneous melanoma
B	Pharos: Q9UBL3	hypertensive disorder osteosarcoma
C [auth A]	Pharos: Q03164	myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia adenocarcinoma leukemia chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia adenocarcinoma leukemia chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer granular cell carcinoma small cell lung carcinoma lymphoid leukemia osteosarcoma Cornelia de Lange syndrome Pick disease cribriform carcinoma of breast gastric neoplasm small cell carcinoma spina bifida hereditary diffuse gastric adenocarcinoma tuberculosis urinary bladder neoplasm Alzheimer disease malignant ependymoma breast cancer medulloblastoma celiac disease ovarian cancer Cornelia de Lange syndrome 1 primitive neuroectodermal tumor acute lymphoblastic leukemia glioblastoma psoriasis hematologic disease subependymal giant cell astrocytoma intellectual disability astrocytic tumor bilineal acute myeloid leukemia malignant mesothelioma Burkitt lymphoma metabolic syndrome X childhood acute lymphoblastic leukemia oligodendroglioma congenital anemia pancreatic ductal adenocarcinoma cribriform carcinoma gastric cancer schizophrenia hepatocellular carcinoma acute undifferentiated leukemia large cell medulloblastoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor brain glioma