Annotations: 5F59

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SET	e5f59A1	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: SET	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.170.270.10	Mainly Beta	Beta Complex	Beta-clip-like	SET domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00856	SET domain (SET)	SET domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Histone-lysine N-methyltransferase 2C	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding binding nucleic acid binding acyltransferase activity transferase activity catalytic activity DNA binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding binding nucleic acid binding acyltransferase activity transferase activity catalytic activity DNA binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity methyltransferase activity histone methyltransferase activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity N-methyltransferase activity histone H3K4 trimethyltransferase activity histone H3K4 monomethyltransferase activity cation binding ion binding metal ion binding small molecule binding	methylation metabolic process cellular process response to electrical stimulus response to stimulus response to abiotic stimulus regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process methylation metabolic process cellular process response to electrical stimulus response to stimulus response to abiotic stimulus regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol MLL3/4 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001965	Zinc finger, PHD-type	Domain
A	IPR046341	SET domain superfamily	Homologous Superfamily
A	IPR001214	SET domain	Domain
A	IPR019787	Zinc finger, PHD-finger	Domain
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR037877	HMT2C, PHD3	Domain
A	IPR041968	KMT2C, ePHD2	Domain
A	IPR047004	KMT2C, PHD2 domain	Domain
A	IPR003616	Post-SET domain	Domain
A	IPR034732	Extended PHD (ePHD) domain	Domain
A	IPR041967	KMT2C, ePHD1	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR003889	FY-rich, C-terminal	Conserved Site
A	IPR000637	HMG-I/HMG-Y, DNA-binding, conserved site	Conserved Site
A	IPR047005	KMT2C, PHD6 domain	Domain
A	IPR003888	FY-rich, N-terminal	Conserved Site
A	IPR001841	Zinc finger, RING-type	Domain
A	IPR009071	High mobility group box domain	Domain
A	IPR047003	KMT2C, PHD4 domain	Domain
A	IPR036910	High mobility group box domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8NEZ4	cholangiocarcinoma acute myeloid leukemia esophageal squamous cell carcinoma transitional cell carcinoma urinary bladder cancer granular cell carcinoma Liver Diseases, Parasitic adenocarcinoma adenoid cystic carcinoma salivary gland adenoid cystic carcinoma intrahepatic cholangiocarcinoma Sezary syndrome tubular adenocarcinoma prostate cancer intellectual disability cholangiocarcinoma acute myeloid leukemia esophageal squamous cell carcinoma transitional cell carcinoma urinary bladder cancer granular cell carcinoma Liver Diseases, Parasitic adenocarcinoma adenoid cystic carcinoma salivary gland adenoid cystic carcinoma intrahepatic cholangiocarcinoma Sezary syndrome tubular adenocarcinoma prostate cancer intellectual disability Kleefstra syndrome 2 myopathy osteosarcoma Pick disease astrocytic tumor colorectal cancer gastric neoplasm urinary bladder neoplasm hepatocellular carcinoma large cell medulloblastoma ovarian cancer adrenal cortex carcinoma primitive neuroectodermal tumor bile duct cancer psoriasis cribriform carcinoma glioblastoma hereditary diffuse gastric adenocarcinoma Kleefstra syndrome 1 medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia amyotrophic lateral sclerosis rheumatoid arthritis cribriform carcinoma of breast spina bifida gastric cancer