4WSQ

Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with small molecule inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4wsqb_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4wsqa_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8099298	3000066	SCOP2B (2022-06-29)
A	SCOP2 Family	Protein kinases catalytic domain-like	8099297	4003661	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protein kinase-like (PK-like)	8099298	3000066	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Pkinase_Tyr	e4wsqB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
A	Pkinase_Tyr	e4wsqA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	AP2-associated protein kinase 1	protein binding binding signaling receptor binding Notch binding protein-containing complex binding AP-2 adaptor complex binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding Notch binding protein-containing complex binding AP-2 adaptor complex binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity histone H2AS1 kinase activity histone modifying activity histone H2A kinase activity histone kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization import into cell regulation of localization regulation of biological process regulation of cellular process regulation of cellular component organization transport regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization regulation of protein stability biological regulation regulation of biological quality protein stabilization import into cell regulation of localization regulation of biological process regulation of cellular process regulation of cellular component organization transport regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization localization clathrin-dependent endocytosis cellular process cellular component organization or biogenesis receptor-mediated endocytosis endocytosis regulation of clathrin-dependent endocytosis regulation of endocytosis protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process protein localization cellular localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization membrane organization presynaptic endocytosis vesicle-mediated transport in synapse establishment of localization in cell cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication positive regulation of Notch signaling pathway positive regulation of signaling	cellular anatomical structure clathrin-coated pit membrane endomembrane system axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction cellular anatomical structure clathrin-coated pit membrane endomembrane system axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle cytosol cell leading edge cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR051744	AP2-associated Ser/Thr protein kinase	Family
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q2M2I8	pilocytic astrocytoma progressive supranuclear palsy rheumatoid arthritis acute myeloid leukemia atrial fibrillation dental caries large cell medulloblastoma malignant glioma osteosarcoma Pancreatic Neuroendocrine Tumor psoriasis subependymal giant cell astrocytoma astrocytic tumor atypical teratoid rhabdoid tumor gastrointestinal stromal tumor pilocytic astrocytoma progressive supranuclear palsy rheumatoid arthritis acute myeloid leukemia atrial fibrillation dental caries large cell medulloblastoma malignant glioma osteosarcoma Pancreatic Neuroendocrine Tumor psoriasis subependymal giant cell astrocytoma astrocytic tumor atypical teratoid rhabdoid tumor gastrointestinal stromal tumor lung cancer medulloblastoma ovarian cancer Pick disease primitive neuroectodermal tumor renal cell carcinoma atopic eczema breast cancer glioblastoma malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.