4V58

Crystal structure of fatty acid synthase from thermomyces lanuginosus at 3.1 angstrom resolution.

External Resource: Annotation

Domain Annotation: ECOD Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
J	EUF08073	e4v58J7	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
J	DUF1729	e4v58J4	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
J	MaoC_dehydratas	e4v58J5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
J	MaoC_dehydrat_N	e4v58J2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
J	FAS1_thioest_ins	e4v58J10	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
J	Acyl_transf_1_1st_1	e4v58J1	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
J	FabD_1st_1	e4v58J8	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
J	COG4981_1	e4v58J3	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
J	NMO	e4v58J6	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
J	Acyl_transf_1_1st	e4v58J9	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
G	EUF08073	e4v58G5	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
G	DUF1729	e4v58G3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
G	MaoC_dehydratas	e4v58G1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
G	MaoC_dehydrat_N	e4v58G6	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
G	FAS1_thioest_ins	e4v58G10	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
G	Acyl_transf_1_1st_1	e4v58G7	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
G	FabD_1st_1	e4v58G4	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
G	COG4981_1	e4v58G8	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
G	NMO	e4v58G2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
G	Acyl_transf_1_1st	e4v58G9	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
H	EUF08073	e4v58H2	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
H	DUF1729	e4v58H8	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
H	MaoC_dehydratas	e4v58H1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
H	MaoC_dehydrat_N	e4v58H3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
H	FAS1_thioest_ins	e4v58H4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
H	Acyl_transf_1_1st_1	e4v58H7	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
H	FabD_1st_1	e4v58H6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
H	COG4981_1	e4v58H10	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
H	NMO	e4v58H5	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
H	Acyl_transf_1_1st	e4v58H9	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
I	EUF08073	e4v58I7	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
I	DUF1729	e4v58I5	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
I	MaoC_dehydratas	e4v58I10	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
I	MaoC_dehydrat_N	e4v58I1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
I	FAS1_thioest_ins	e4v58I9	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
I	Acyl_transf_1_1st_1	e4v58I4	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
I	FabD_1st_1	e4v58I8	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
I	COG4981_1	e4v58I6	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
I	NMO	e4v58I2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
I	Acyl_transf_1_1st	e4v58I3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
K	EUF08073	e4v58K1	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
K	DUF1729	e4v58K7	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
K	MaoC_dehydratas	e4v58K9	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
K	MaoC_dehydrat_N	e4v58K2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
K	FAS1_thioest_ins	e4v58K3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
K	Acyl_transf_1_1st_1	e4v58K5	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
K	FabD_1st_1	e4v58K8	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
K	COG4981_1	e4v58K6	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
K	NMO	e4v58K10	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
K	Acyl_transf_1_1st	e4v58K4	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
L	EUF08073	e4v58L6	A: alpha bundles	X: N-terminal domain in fatty acid synthase subunit beta (From Topology)	H: N-terminal domain in fatty acid synthase subunit beta (From Topology)	T: N-terminal domain in fatty acid synthase subunit beta	F: EUF08073	ECOD (1.6)
L	DUF1729	e4v58L2	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: DUF1729	ECOD (1.6)
L	MaoC_dehydratas	e4v58L7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydratas	ECOD (1.6)
L	MaoC_dehydrat_N	e4v58L1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: MaoC_dehydrat_N	ECOD (1.6)
L	FAS1_thioest_ins	e4v58L3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Insertion domain in thioesterase (From Topology)	T: Insertion domain in thioesterase	F: FAS1_thioest_ins	ECOD (1.6)
L	Acyl_transf_1_1st_1	e4v58L5	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_1st_1	ECOD (1.6)
L	FabD_1st_1	e4v58L10	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: FabD_1st_1	ECOD (1.6)
L	COG4981_1	e4v58L9	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: COG4981_1	ECOD (1.6)
L	NMO	e4v58L4	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NMO	ECOD (1.6)
L	Acyl_transf_1_1st	e4v58L8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
C	FabG2_2nd	e4v58C4	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
C	adh_short_C2	e4v58C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
C	ketoacyl-synt	e4v58C1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
A	FabG2_2nd	e4v58A4	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
A	adh_short_C2	e4v58A3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
A	ketoacyl-synt	e4v58A5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
B	FabG2_2nd	e4v58B2	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
B	adh_short_C2	e4v58B3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
B	ketoacyl-synt	e4v58B5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
D	FabG2_2nd	e4v58D4	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
D	adh_short_C2	e4v58D3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
D	ketoacyl-synt	e4v58D5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
E	FabG2_2nd	e4v58E3	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
E	adh_short_C2	e4v58E1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
E	ketoacyl-synt	e4v58E5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
F	FabG2_2nd	e4v58F4	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: FabG2_2nd	ECOD (1.6)
F	adh_short_C2	e4v58F2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2	ECOD (1.6)
F	ketoacyl-synt	e4v58F5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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4V58

Crystal structure of fatty acid synthase from thermomyces lanuginosus at 3.1 angstrom resolution.

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage