Annotations: 4URQ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth V]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)
C [auth W]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)
E [auth Y]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)
A [auth U]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)
D [auth X]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)
F [auth Z]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8100720	3001272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth V]	GGDEF	e4urqV1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)
C [auth W]	GGDEF	e4urqW1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)
E [auth Y]	GGDEF	e4urqY1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)
A [auth U]	GGDEF	e4urqU1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)
D [auth X]	GGDEF	e4urqX1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)
F [auth Z]	GGDEF	e4urqZ1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: GGDEF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth V]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
C [auth W]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
E [auth Y]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
A [auth U]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
D [auth X]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
F [auth Z]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], F [auth Z]	DIGUANYLATE CYCLASE	binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], F [auth Z]	IPR000160	GGDEF domain	Domain
A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], F [auth Z]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], F [auth Z]	IPR052163	Diguanylate Cyclase/Regulatory Protein	Family
A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], A [auth U], B [auth V], C [auth W], D [auth X], E [auth Y], F [auth Z]	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.