Annotations: 4NSC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_3	e4nscA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
A	EF-hand_7_12	e4nscA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)
B	EF-hand_7_3	e4nscB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
B	EF-hand_7_12	e4nscB3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)
C	EF-hand_7_3	e4nscC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
C	EF-hand_7_12	e4nscC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)
D	EF-hand_7_3	e4nscD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
D	EF-hand_7_12	e4nscD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)
E	EF-hand_7_3	e4nscE2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
E	EF-hand_7_12	e4nscE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)
F	EF-hand_7_3	e4nscF1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_3	ECOD (1.6)
F	EF-hand_7_12	e4nscF2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_12	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13202	EF hand (EF-hand_5)	EF hand		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Calcium uptake protein 1, mitochondrial	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity molecular sensor activity calcium ion sensor activity metal ion sensor activity molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity channel inhibitor activity ion channel inhibitor activity identical protein binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport cellular process calcium import into the mitochondrion monoatomic cation transport calcium ion transmembrane transport mitochondrial transport membrane organization positive regulation of organelle organization regulation of biological process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cristae formation inner mitochondrial membrane organization regulation of cristae formation biological regulation positive regulation of biological process regulation of organelle organization mitochondrial membrane organization cellular component organization positive regulation of cristae formation organelle organization regulation of mitochondrion organization cellular component organization or biogenesis positive regulation of cellular process mitochondrion organization mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to calcium ion starvation cellular response to starvation defense response regulation of cellular hyperosmotic salinity response regulation of cellular response to stress cellular hyperosmotic salinity response cellular response to chemical stress response to salt stress regulation of response to osmotic stress cellular response to environmental stimulus hyperosmotic salinity response regulation of response to salt stress hyperosmotic response regulation of cellular response to osmotic stress cellular hyperosmotic response regulation of response to stress response to osmotic stress cellular response to salt stress cellular response to osmotic stress cellular response to chemical stimulus regulation of response to stimulus response to chemical response to abiotic stimulus cellular response to abiotic stimulus cellular response to metal ion response to metal ion cellular response to calcium ion response to calcium ion calcium ion import cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization positive regulation of mitochondrial calcium ion concentration	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial crista junction organelle membrane contact site protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen uniplex complex mitochondrial protein-containing complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR039800	Calcium uptake protein 1/2/3	Family
A, B, C, D, E A, B, C, D, E, F	IPR002048	EF-hand domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018247	EF-Hand 1, calcium-binding site	Binding Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9BPX6	proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.