4LAV

Crystal Structure Analysis of FKBP52, Crystal Form II

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4lavb1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP52, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4lava1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP52, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Rotamase-like	8038431	3000622	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Rotamase-like	8038433	3000622	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Rotamase-like	8038431	3000622	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Rotamase-like	8038433	3000622	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	FKBP_C	e4lavB1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
A	FKBP_C	e4lavA1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Peptidyl-prolyl cis-trans isomerase FKBP4	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity phosphoprotein binding FK506 binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity phosphoprotein binding FK506 binding amide binding organic cyclic compound binding macrolide binding copper-dependent protein binding heat shock protein binding RNA binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding adenyl nucleotide binding ATP binding cytoskeletal protein binding tau protein binding	protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization microtubule cytoskeleton organization negative regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization cellular component organization or biogenesis protein polymerization negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization developmental process multicellular organismal process reproductive system development prostate gland development reproductive process gland development animal organ development urogenital system development developmental process involved in reproduction multicellular organism development anatomical structure development reproductive structure development system development chaperone-mediated protein folding localization transport copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport male sex differentiation sex differentiation protein-containing complex localization regulation of neuron projection development cellular developmental process cell projection organization cell development neuron projection development neurogenesis neuron differentiation cell differentiation negative regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process steroid hormone receptor complex assembly	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle growth cone axon cell projection distal axon neuron projection axonal growth cone membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B	IPR019734	Tetratricopeptide repeat	Repeat
A, B	IPR050754	Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like	Family
A, B	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
A, B	IPR013105	Tetratricopeptide repeat 2	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q02790	subependymal giant cell astrocytoma breast cancer ductal breast carcinoma in situ lung cancer malignant glioma non-small cell lung carcinoma Prevention of Cardiac Transplant Rejection rheumatoid arthritis breast carcinoma interstitial cystitis lung carcinoma malignant mesothelioma ovarian cancer dry eye syndrome invasive ductal breast carcinoma subependymal giant cell astrocytoma breast cancer ductal breast carcinoma in situ lung cancer malignant glioma non-small cell lung carcinoma Prevention of Cardiac Transplant Rejection rheumatoid arthritis breast carcinoma interstitial cystitis lung carcinoma malignant mesothelioma ovarian cancer dry eye syndrome invasive ductal breast carcinoma major depressive disorder mucocutaneous lymph node syndrome pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.