Annotations: 4CBX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth G]	d4cbxg_	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	Gelsolin-like	automated matches	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d4cbxa1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Plasmodium berghei ) [TaxId: 5821 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth G]	SCOP2B Superfamily	Actin depolymerizing proteins	8070774	3000430	SCOP2B (2022-06-29)
A	SCOP2 Family	Actin/HSP70	8082550	4000313	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8092423	3000092	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8082551	3000092	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth G]	Gelsolin_1	e4cbxG1	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: Gelsolin_1	ECOD (1.6)
A	Actin_1st	e4cbxA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
A	Actin_2nd	e4cbxA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth G]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth G]	PF00626	Gelsolin repeat (Gelsolin)	Gelsolin repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth G]	GELSOLIN	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding phosphatidylinositol 3-kinase catalytic subunit binding phosphatidylinositol 3-kinase binding kinase binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding phosphatidylinositol 3-kinase catalytic subunit binding phosphatidylinositol 3-kinase binding kinase binding enzyme binding myosin II binding myosin binding	regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity establishment of lymphocyte polarity multicellular organismal process regulation of biological process regulation of cellular process establishment of T cell polarity cell activation biological regulation establishment or maintenance of cell polarity lymphocyte activation leukocyte activation establishment of cell polarity regulation of establishment of cell polarity immune system process regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity establishment of lymphocyte polarity multicellular organismal process regulation of biological process regulation of cellular process establishment of T cell polarity cell activation biological regulation establishment or maintenance of cell polarity lymphocyte activation leukocyte activation establishment of cell polarity regulation of establishment of cell polarity immune system process T cell activation cellular process system process relaxation of cardiac muscle muscle system process relaxation of muscle membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination positive regulation of epithelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process positive regulation of keratinocyte apoptotic process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process keratinocyte apoptotic process regulation of keratinocyte apoptotic process apoptotic process programmed cell death positive regulation of cellular process positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process positive regulation of cellular component organization regulation of actin nucleation actin filament-based process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization cytoskeleton organization protein destabilization regulation of protein stability regulation of biological quality actin filament severing metabolic process primary metabolic process protein metabolic process macromolecule metabolic process amyloid fibril formation muscle atrophy striated muscle adaptation muscle adaptation response to stimulus striated muscle atrophy protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of localization cellular localization plasma membrane raft distribution plasma membrane raft polarization plasma membrane organization membrane raft organization endomembrane system organization membrane raft distribution plasma membrane raft localization membrane raft polarization regulation of plasma membrane raft polarization localization within membrane membrane raft localization regulation of plasma membrane organization regulation of cellular localization cellular component disassembly protein-containing complex disassembly actin filament depolymerization protein depolymerization biological process involved in interspecies interaction between organisms negative regulation of viral life cycle negative regulation of biological process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process negative regulation of viral process symbiont entry into host cell viral process symbiont entry into host negative regulation of viral entry into host cell regulation of biological process involved in symbiotic interaction organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly cilium organization cell projection assembly immune response response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus response to peptide response to chemical defense response to other organism response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus regulation of cellular component size regulation of protein-containing complex disassembly regulation of actin filament depolymerization actin filament capping negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization negative regulation of cellular component organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process negative regulation of protein polymerization regulation of actin filament polymerization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length negative regulation of actin filament depolymerization regulation of anatomical structure size hepatocyte apoptotic process protein localization regulation of protein localization protein localization to membrane cellular macromolecule localization macromolecule localization receptor clustering regulation of receptor clustering regulation of protein localization to membrane podosome assembly membraneless organelle assembly regulation of podosome assembly regulation of organelle assembly maintenance of location maintenance of protein location maintenance of location in cell maintenance of protein location in cell sequestering of actin monomers heart process cardiac muscle cell contraction actin filament-based movement cardiac muscle contraction muscle contraction striated muscle contraction circulatory system process actin-mediated cell contraction heart contraction blood circulation regulation of protein maturation positive regulation of protein maturation positive regulation of protein metabolic process regulation of protein processing in phagocytic vesicle positive regulation of macromolecule biosynthetic process positive regulation of protein processing regulation of primary metabolic process protein maturation positive regulation of metabolic process regulation of proteolysis positive regulation of biosynthetic process proteolysis positive regulation of macromolecule metabolic process positive regulation of protein processing in phagocytic vesicle regulation of biosynthetic process regulation of protein metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process protein processing in phagocytic vesicle regulation of gene expression biosynthetic process positive regulation of gene expression regulation of protein processing positive regulation of proteolysis protein processing regulation of macromolecule biosynthetic process regulation of metabolic process renal system process renal absorption renal protein absorption response to mechanical stimulus response to abiotic stimulus response to muscle stretch	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle vesicle endocytic vesicle cell periphery plasma membrane membrane cell cortex cortical cytoskeleton actin cap cortical actin cytoskeleton extracellular region sarcoplasm extracellular space nucleus
A	ACTIN-2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	sexual reproduction reproductive process multicellular organismal reproductive process male gamete generation gamete generation cellular component organization organelle organization plasma membrane bounded cell projection organization cell projection organization cellular process cellular component organization or biogenesis cilium organization regulation of biological process positive regulation of formation of structure involved in a symbiotic process sexual reproduction reproductive process multicellular organismal reproductive process male gamete generation gamete generation cellular component organization organelle organization plasma membrane bounded cell projection organization cell projection organization cellular process cellular component organization or biogenesis cilium organization regulation of biological process positive regulation of formation of structure involved in a symbiotic process biological process involved in interspecies interaction between organisms modulation of formation of structure involved in a symbiotic process biological regulation positive regulation of biological process positive regulation of development of symbiont in host formation of structure involved in a symbiotic process regulation of development of symbiont in host development of symbiont in host exit from host cell biological process involved in interaction with host biological process involved in symbiotic interaction	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth G]	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily
B [auth G]	IPR007122	Villin/Gelsolin	Family
B [auth G]	IPR007123	Gelsolin-like domain	Domain
A	IPR020902	Actin/actin-like conserved site	Conserved Site
A	IPR004001	Actin, conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR004000	Actin family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.