3TSW

crystal structure of the PDZ3-SH3-GUK core module of Human ZO-1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH3-domain	8091663	3000153	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PDZ domain-like	8019122	3000388	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8091662	3002021	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PDZ domain-like	8019122	3000388	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SH3-domain	8091663	3000153	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SH3-domain	8091663	3000153	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PDZ domain-like	8019122	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8019122	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SH3-domain	8091663	3000153	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8091662	3002021	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_2	e3tswA7	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_2	ECOD (1.6)
A	PDZ	e3tswA6	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
A	Guanylate_kin	e3tswA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Guanylate_kin	ECOD (1.6)
B	SH3_2	e3tswB4	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_2	ECOD (1.6)
B	PDZ	e3tswB3	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
D	SH3_2	e3tswD4	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_2	ECOD (1.6)
D	PDZ	e3tswD3	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
C	SH3_2	e3tswC7	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_2	ECOD (1.6)
C	PDZ	e3tswC6	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
C	Guanylate_kin	e3tswC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Guanylate_kin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
D	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
D	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A, B, C, D	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tight junction protein ZO-1	cell adhesion molecule binding cadherin binding protein binding binding calmodulin binding	developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation endothelial cell development establishment of endothelial intestinal barrier epithelial cell development cell differentiation establishment of endothelial barrier anatomical structure development developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation endothelial cell development establishment of endothelial intestinal barrier epithelial cell development cell differentiation establishment of endothelial barrier anatomical structure development cellular process cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation regulation of cellular component biogenesis regulation of cell junction assembly protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to cell junction protein localization to cell-cell junction positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of cell-cell adhesion mediated by cadherin cell-cell adhesion mediated by cadherin regulation of cell-cell adhesion positive regulation of cellular process regulation of cell-cell adhesion mediated by cadherin negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly actin filament bundle organization stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization bicellular tight junction assembly regulation of bicellular tight junction assembly tight junction organization apical junction assembly tight junction assembly adherens junction organization cell junction maintenance cellular component maintenance adherens junction maintenance cell-cell junction maintenance cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion multicellular organismal process regulation of sprouting angiogenesis regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process multicellular organism development tube morphogenesis positive regulation of sprouting angiogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process regulation of blood-brain barrier permeability system process maintenance of blood-brain barrier homeostatic process positive regulation of vascular permeability positive regulation of blood-brain barrier permeability tissue homeostasis regulation of vascular permeability circulatory system process multicellular organismal-level homeostasis vascular process in circulatory system anatomical structure homeostasis regulation of biological quality blood circulation protein localization to adherens junction protein localization to bicellular tight junction ameloblast differentiation columnar/cuboidal epithelial cell differentiation	cellular anatomical structure apical part of cell intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol cell periphery basal part of cell cellular anatomical structure apical part of cell intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane apical junction complex cell-cell junction anchoring junction cell junction adherens junction gap junction protein-containing complex bicellular tight junction tight junction cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005417	Tight junction protein ZO	Family
A, B, C, D	IPR035597	ZO-1, SH3 domain	Domain
A, B, C, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR000906	ZU5 domain	Domain
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D	IPR001452	SH3 domain	Domain
A, B, C, D	IPR008144	Guanylate kinase-like domain	Domain
A, B, C, D	IPR005418	Tight junction protein ZO-1	Family
A, B, C, D	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A, B, C, D	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C, D	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q07157	subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor dermatomyositis glioblastoma malignant ependymoma medulloblastoma ovarian cancer psoriasis cancer Down syndrome lung adenocarcinoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm spina bifida subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor dermatomyositis glioblastoma malignant ependymoma medulloblastoma ovarian cancer psoriasis cancer Down syndrome lung adenocarcinoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm spina bifida colitis esophageal adenocarcinoma lung cancer MALT lymphoma osteosarcoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.